Uvod
Oduvijek su se ljudi pitali zašto djeca nalikuju na svoje roditelje.
Prve odgovore na to pitanje dao je češki redovnik Gregor Mendel. Mendel, koji je u Pragu završio studij prirodoslovlja bio je zaljubljenik u povrtlarstvo te je za svoja istraživanja nasljeđivanja odabrao vrtni grašak (Pisum sativum).
Ova se biljka zbog niza svojstava pokazala odličnim odabirom za proučavanje modela nasljeđivanja. Naglasak Mendelovih istraživanja bio je na praćenju dviju kontrastnih karakteristika istog svojstva kao što su primjerice visoka i niska stabljika kada se one kombiniraju u križancima. Nakon pomno analiziranih rezultata Mendel je 1865. objavio svoja zapažanja koja isprva nisu privukla pažnju znanstvenog svijeta. U svojim zapažanjima on je naveo da nasljeđivanje ima ''čestičnu prirodu'' te da u svakoj biljci postoji ''nasljedni faktor'' koji se prenosi na potomstvo i određuje neku osobinu. Time je Mendel prvi došao na zamisao o postojanju gena. Danas znamo da su geni pohranjeni u deoksiribonukleinskoj kiselini, DNA.
Ova se biljka zbog niza svojstava pokazala odličnim odabirom za proučavanje modela nasljeđivanja.
Naglasak Mendelovih istraživanja bio je na praćenju dviju kontrastnih karakteristika istog svojstva.
Primjerice visoka i niska stabljika kada se one kombiniraju u križancima.
Nakon pomno analiziranih rezultata Mendel je 1865. objavio svoja zapažanja.
Isprva nisu privukla pažnju znanstvenog svijeta.
U svojim zapažanjima on je naveo da nasljeđivanje ima ''čestičnu prirodu'' .
U svakoj biljci postoji ''nasljedni faktor'' koji se prenosi na potomstvo i određuje neku osobinu.
Time je Mendel prvi došao na zamisao o postojanju gena.
Danas znamo da su geni pohranjeni u deoksiribonukleinskoj kiselini, DNA.
(lat. nucleus - jezgra) su makromolekule zadužene za prijenos nasljedne upute. Dvije su vrste nukleinskih kiselina: deoksiribonukleinska kiselina ili DNA (eng. deoxyribonucleic acid) i ribonukleinska kiselina ili RNA (eng. ribonucleic acid). One se međusobno razlikuju po sastavu, strukturi i zadaći u procesu prijenosa nasljedne upute.
Nukleinske kiseline (lat. nucleus - jezgra) su makromolekule zadužene za prijenos nasljedne upute.
Dvije su vrste nukleinskih kiselina:
- deoksiribonukleinska kiselina ili DNA (eng. deoxyribonucleic acid) i
- ribonukleinska kiselina ili RNA (eng. ribonucleic acid).
One se međusobno razlikuju po sastavu, strukturi i zadaći u procesu prijenosa nasljedne upute.
Osnovna građevna jedinica nukleinskih kiselina jeste nukleotid. Povezivanjem nukleotida nastaje polimerni lanac nazvan polinukleotid.
Ovisno o vrsti šećera koji nukleotid sadržava razlikujemo i dvije vrste nukleinskih kiselina: ribonukleinsku (RNA) i deoksiribonukleinsku kiselinu (DNA). Ribonukleinska kiselina sadržava šećer D-ribozu u furanoznom obliku, a deoksiribonukleinska kiselina sadržava šećer 2-deoksi-D-ribozu, također u furanoznom obliku.
Ovisno o vrsti šećera koji nukleotid sadržava razlikujemo
i dvije vrste nukleinskih kiselina: ribonukleinsku (RNA) i deoksiribonukleinsku kiselinu (DNA).
Ribonukleinska kiselina sadržava šećer D-ribozu u furanoznom obliku.
Deoksiribonukleinska kiselina sadržava šećer 2-deoksi-D-ribozu, također u furanoznom obliku.
Baze koje ulaze u sastav nukleotida su heterociklički aromatski amini izraženih bazičnih svojstava zbog prisutnosti više dušikovih atoma u molekuli. Baze se nazivaju prema osnovnom spoju od kojeg se odvode, purinu ili pirmidinu.
Purinske baze su adenin i gvanin, a pirimidinske baze su citozin, timin i uracil. Purin je heterociklički aromatski amin sastavljen od pirimidina i imidazola.
Baze koje ulaze u sastav nukleotida su heterociklički aromatski amini
izraženih bazičnih svojstava zbog prisutnosti više dušikovih atoma u molekuli.
Baze se nazivaju prema osnovnom spoju od kojeg se odvode, purinu ili pirmidinu.
Purinske baze su adenin i gvanin.
Pirimidinske baze su citozin, timin i uracil.
Purin je heterociklički aromatski amin sastavljen od pirimidina i imidazola.
Problemski zadatak
Koristeći rotirajuće trodimenzijske modele molekula purina i pirimidina usporedite njihovu strukturu i sastav te nacrtajte njihove skeletne formule.
9260
-OEChem-03042008503D
10 10 0 0 0 0 0 0 0999 V2000
1.2035 -0.6989 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.2063 -0.6943 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
0.0028 1.3870 0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
1.1692 0.6499 -0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.1666 0.6543 -0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.0026 -1.2980 0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
0.0048 2.4686 0.0002 H 0 0 0 0 0 0 0 0 0 0 0 0
2.1379 1.1383 -0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
-2.1333 1.1465 -0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
-0.0046 -2.3812 0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
1 4 2 0 0 0 0
1 6 1 0 0 0 0
2 5 1 0 0 0 0
2 6 2 0 0 0 0
3 4 1 0 0 0 0
3 5 2 0 0 0 0
3 7 1 0 0 0 0
4 8 1 0 0 0 0
5 9 1 0 0 0 0
6 10 1 0 0 0 0
M END
> <PUBCHEM_COMPOUND_CID>
9260
> <PUBCHEM_CONFORMER_RMSD>
0.4
> <PUBCHEM_CONFORMER_DIVERSEORDER>
1
> <PUBCHEM_MMFF94_PARTIAL_CHARGES>
10
1 -0.62
10 0.15
2 -0.62
3 -0.15
4 0.16
5 0.16
6 0.47
7 0.15
8 0.15
9 0.15
> <PUBCHEM_EFFECTIVE_ROTOR_COUNT>
0
> <PUBCHEM_PHARMACOPHORE_FEATURES>
3
1 1 acceptor
3 1 2 6 cation
6 1 2 3 4 5 6 rings
> <PUBCHEM_HEAVY_ATOM_COUNT>
6
> <PUBCHEM_ATOM_DEF_STEREO_COUNT>
0
> <PUBCHEM_ATOM_UDEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_DEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_UDEF_STEREO_COUNT>
0
> <PUBCHEM_ISOTOPIC_ATOM_COUNT>
0
> <PUBCHEM_COMPONENT_COUNT>
1
> <PUBCHEM_CACTVS_TAUTO_COUNT>
1
> <PUBCHEM_CONFORMER_ID>
0000242C00000001
> <PUBCHEM_MMFF94_ENERGY>
13.0497
> <PUBCHEM_FEATURE_SELFOVERLAP>
15.223
> <PUBCHEM_SHAPE_FINGERPRINT>
20096714 4 18411421674288461041
21015797 1 9295291637893783780
21040471 1 18338517542265193189
> <PUBCHEM_SHAPE_MULTIPOLES>
113.52
1.53
1.48
0.59
0.01
0
0
0
0
-0.01
0
-0.02
0
0
> <PUBCHEM_SHAPE_SELFOVERLAP>
231.01
> <PUBCHEM_SHAPE_VOLUME>
63.2
> <PUBCHEM_COORDINATE_TYPE>
2
5
10
$$$$
1044
-OEChem-03042008503D
13 14 0 0 0 0 0 0 0999 V2000
1.5118 -1.1529 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
1.5927 1.0746 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-0.8100 1.4453 0.0001 N 0 0 0 0 0 0 0 0 0 0 0 0
-2.1255 -0.6093 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
0.2115 -0.7347 -0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2880 0.6516 -0.0001 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.0118 -1.3756 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.3019 -0.0338 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.9585 0.7348 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.8350 -2.1113 0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
-1.1359 -2.4493 0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
3.3807 -0.0973 0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0
-2.8723 1.3193 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
1 5 1 0 0 0 0
1 8 1 0 0 0 0
1 10 1 0 0 0 0
2 6 1 0 0 0 0
2 8 2 0 0 0 0
3 6 2 0 0 0 0
3 9 1 0 0 0 0
4 7 1 0 0 0 0
4 9 2 0 0 0 0
5 6 1 0 0 0 0
5 7 2 0 0 0 0
7 11 1 0 0 0 0
8 12 1 0 0 0 0
9 13 1 0 0 0 0
M END
> <PUBCHEM_COMPOUND_CID>
1044
> <PUBCHEM_CONFORMER_RMSD>
0.4
> <PUBCHEM_CONFORMER_DIVERSEORDER>
1
> <PUBCHEM_MMFF94_PARTIAL_CHARGES>
13
1 0.03
10 0.27
11 0.15
12 0.15
13 0.15
2 -0.57
3 -0.57
4 -0.62
5 -0.15
6 0.48
7 0.16
8 0.04
9 0.47
> <PUBCHEM_EFFECTIVE_ROTOR_COUNT>
0
> <PUBCHEM_PHARMACOPHORE_FEATURES>
6
1 1 donor
3 1 2 8 cation
3 2 3 6 cation
3 3 4 9 cation
5 1 2 5 6 8 rings
6 3 4 5 6 7 9 rings
> <PUBCHEM_HEAVY_ATOM_COUNT>
9
> <PUBCHEM_ATOM_DEF_STEREO_COUNT>
0
> <PUBCHEM_ATOM_UDEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_DEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_UDEF_STEREO_COUNT>
0
> <PUBCHEM_ISOTOPIC_ATOM_COUNT>
0
> <PUBCHEM_COMPONENT_COUNT>
1
> <PUBCHEM_CACTVS_TAUTO_COUNT>
4
> <PUBCHEM_CONFORMER_ID>
0000041400000001
> <PUBCHEM_MMFF94_ENERGY>
14.0969
> <PUBCHEM_FEATURE_SELFOVERLAP>
31.104
> <PUBCHEM_SHAPE_FINGERPRINT>
16945 1 18410573985198949894
18185500 45 18266739271404190231
21040471 1 18338517434864533088
23552423 10 18260833695836079510
2748010 2 18410575088984426639
29004967 10 18262242234444578715
5084963 1 18271805692067306995
> <PUBCHEM_SHAPE_MULTIPOLES>
165.29
2.8
1.47
0.58
0.24
0.02
0
-0.04
0
-0.21
0
0
0.01
0
> <PUBCHEM_SHAPE_SELFOVERLAP>
366.148
> <PUBCHEM_SHAPE_VOLUME>
87.9
> <PUBCHEM_COORDINATE_TYPE>
2
5
10
$$$$
Šećer i baza bez fosfatne skupine povezani su N-glikozidnom vezom pa te spojeve nazivamo nukleozidima. Razlikuju se ribonukleozid i deoksiribonukleozid. Imena nukleozida su trivijalna i izvode se iz imena baze i šećera s kojim je vezana, tako se primjerice adenin vezan na D-ribozu naziva adenozin, a adenin vezan na 2-deoksi-D-ribozu se naziva deoksiadenozin.
Šećer i baza bez fosfatne skupine povezani su N-glikozidnom vezom.
Te spojeve nazivamo nukleozidima.
Razlikuju se ribonukleozid i deoksiribonukleozid.
Imena nukleozida su trivijalna i izvode se iz imena baze i šećera s kojim je vezana.
Tako se primjerice adenin vezan na D-ribozu naziva adenozin.
Adenin vezan na 2-deoksi-D-ribozu se naziva deoksiadenozin.
Problemski zadatak
Koristeći rotirajući trodimenzijski model purinskog ribonukleozida uočite da je C-1 anomerni ugljik riboze ß-konfiguracije te da se povezuje ß-N-glikozidnom vezom s N-9 dušikovim atomom purinske baze.
Koristeći rotirajući trodimenzijski model purinskog ribonukleozida
uočite da je C-1 anomerni ugljik riboze ß-konfiguracije.
Uočite da se povezuje ß-N-glikozidnom vezom s N-9 dušikovim atomom purinske baze.
68368
-OEChem-03042008563D
30 32 0 1 0 0 0 0 0999 V2000
1.7661 -0.4894 -0.9456 O 0 0 0 0 0 0 0 0 0 0 0 0
0.7998 2.2860 1.1242 O 0 0 0 0 0 0 0 0 0 0 0 0
2.9664 2.2805 -0.5162 O 0 0 0 0 0 0 0 0 0 0 0 0
3.7216 -2.4111 -0.3576 O 0 0 0 0 0 0 0 0 0 0 0 0
-0.4456 -0.3765 -0.0936 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.7321 -2.0982 0.5057 N 0 0 0 0 0 0 0 0 0 0 0 0
-2.1594 1.2901 -0.5265 N 0 0 0 0 0 0 0 0 0 0 0 0
-4.3935 0.3893 -0.1345 N 0 0 0 0 0 0 0 0 0 0 0 0
1.3999 1.0427 0.8228 C 0 0 1 0 0 0 0 0 0 0 0 0
0.7643 0.3860 -0.3931 C 0 0 1 0 0 0 0 0 0 0 0 0
2.8426 1.1727 0.3756 C 0 0 1 0 0 0 0 0 0 0 0 0
3.0571 -0.1173 -0.4098 C 0 0 1 0 0 0 0 0 0 0 0 0
3.5654 -1.2617 0.4559 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.7360 0.0688 -0.1677 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.4969 -1.6843 0.3147 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.5169 -1.0125 0.2078 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.8948 -0.8203 0.2172 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.5079 1.3551 -0.4794 C 0 0 0 0 0 0 0 0 0 0 0 0
1.3312 0.3968 1.7057 H 0 0 0 0 0 0 0 0 0 0 0 0
0.4957 1.1153 -1.1672 H 0 0 0 0 0 0 0 0 0 0 0 0
3.5416 1.3283 1.2024 H 0 0 0 0 0 0 0 0 0 0 0 0
3.7231 0.0239 -1.2686 H 0 0 0 0 0 0 0 0 0 0 0 0
2.8645 -1.5147 1.2575 H 0 0 0 0 0 0 0 0 0 0 0 0
4.5353 -1.0191 0.8998 H 0 0 0 0 0 0 0 0 0 0 0 0
0.9121 2.8688 0.3541 H 0 0 0 0 0 0 0 0 0 0 0 0
3.8901 2.3067 -0.8192 H 0 0 0 0 0 0 0 0 0 0 0 0
0.3905 -2.2848 0.4614 H 0 0 0 0 0 0 0 0 0 0 0 0
2.8544 -2.6140 -0.7482 H 0 0 0 0 0 0 0 0 0 0 0 0
-4.6098 -1.5851 0.4909 H 0 0 0 0 0 0 0 0 0 0 0 0
-3.9420 2.3104 -0.7550 H 0 0 0 0 0 0 0 0 0 0 0 0
1 10 1 0 0 0 0
1 12 1 0 0 0 0
2 9 1 0 0 0 0
2 25 1 0 0 0 0
3 11 1 0 0 0 0
3 26 1 0 0 0 0
4 13 1 0 0 0 0
4 28 1 0 0 0 0
5 10 1 0 0 0 0
5 14 1 0 0 0 0
5 15 1 0 0 0 0
6 15 2 0 0 0 0
6 16 1 0 0 0 0
7 14 2 0 0 0 0
7 18 1 0 0 0 0
8 17 1 0 0 0 0
8 18 2 0 0 0 0
9 10 1 0 0 0 0
9 11 1 0 0 0 0
9 19 1 0 0 0 0
10 20 1 0 0 0 0
11 12 1 0 0 0 0
11 21 1 0 0 0 0
12 13 1 0 0 0 0
12 22 1 0 0 0 0
13 23 1 0 0 0 0
13 24 1 0 0 0 0
14 16 1 0 0 0 0
15 27 1 0 0 0 0
16 17 2 0 0 0 0
17 29 1 0 0 0 0
18 30 1 0 0 0 0
M END
> <PUBCHEM_COMPOUND_CID>
68368
> <PUBCHEM_CONFORMER_RMSD>
0.6
> <PUBCHEM_CONFORMER_DIVERSEORDER>
3
10
12
11
2
13
9
8
5
15
6
1
16
7
4
14
> <PUBCHEM_MMFF94_PARTIAL_CHARGES>
24
1 -0.56
10 0.54
11 0.28
12 0.28
13 0.28
14 0.11
15 0.04
16 0.23
17 0.16
18 0.47
2 -0.68
25 0.4
26 0.4
27 0.15
28 0.4
29 0.15
3 -0.68
30 0.15
4 -0.68
5 0.05
6 -0.57
7 -0.57
8 -0.62
9 0.28
> <PUBCHEM_EFFECTIVE_ROTOR_COUNT>
3
> <PUBCHEM_PHARMACOPHORE_FEATURES>
13
1 1 acceptor
1 2 acceptor
1 2 donor
1 3 acceptor
1 3 donor
1 4 acceptor
1 4 donor
3 5 6 15 cation
3 5 7 14 cation
3 7 8 18 cation
5 1 9 10 11 12 rings
5 5 6 14 15 16 rings
6 7 8 14 16 17 18 rings
> <PUBCHEM_HEAVY_ATOM_COUNT>
18
> <PUBCHEM_ATOM_DEF_STEREO_COUNT>
4
> <PUBCHEM_ATOM_UDEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_DEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_UDEF_STEREO_COUNT>
0
> <PUBCHEM_ISOTOPIC_ATOM_COUNT>
0
> <PUBCHEM_COMPONENT_COUNT>
1
> <PUBCHEM_CACTVS_TAUTO_COUNT>
1
> <PUBCHEM_CONFORMER_ID>
00010B1000000003
> <PUBCHEM_MMFF94_ENERGY>
40.9542
> <PUBCHEM_FEATURE_SELFOVERLAP>
66.592
> <PUBCHEM_SHAPE_FINGERPRINT>
10130415 120 18342457015318394680
10608611 8 18338514252357265157
10922523 26 18408321090221475254
1100329 8 16609977137552113346
12403259 226 18410851071188588965
12403259 415 18187361000616651253
124424 183 18341891870399360070
12500047 106 18337105790773035526
12507560 14 18130504145847237166
12932764 1 17916586599362382046
13134695 92 17774427309687374544
13571099 22 18412545379804677482
14115302 16 18188219714712994878
14866123 147 16973369063712085354
15196674 1 18409166623727819213
15219456 202 18412544348653765365
15442244 35 18338800018132788208
15536298 74 18410007736784764754
16945 1 18269287763284710926
17804303 29 18334861580135011407
18186145 218 18341337712397000461
19049666 15 18411135865689684048
200 152 17632853127490448095
20510252 161 18409732906649910409
20645477 70 18343867718738675790
21501502 16 18340482395245235078
21524375 3 18336262349965524791
23402539 116 18129932391374071237
23419403 2 17484484921207052200
23559900 14 18411980252613891552
3004659 81 17969792870003165518
3286 77 18273208712270889933
335352 9 18265332802959053935
474 4 16010447995996582020
495365 180 17703214209087786040
5104073 3 18409450301901421323
57426455 114 18410848854484492835
633830 44 18259978271731910575
69090 78 18343297102537630335
7364860 26 18411138073925288148
74978 22 18408323297892648634
81228 2 17827072111304152963
8809292 202 18409451366604981954
9709674 26 18336267937153870722
> <PUBCHEM_SHAPE_MULTIPOLES>
327.03
7.45
2.29
0.83
1.86
0.06
0.06
0.59
-0.49
-1.23
0.21
-0.24
-0.16
0.58
> <PUBCHEM_SHAPE_SELFOVERLAP>
712.374
> <PUBCHEM_SHAPE_VOLUME>
175.7
> <PUBCHEM_COORDINATE_TYPE>
2
5
10
$$$$
esterificiran fosfornom kiselinom čini nukleotid. U esterifikaciju fosfornom kiselinom najčešće stupa hidroksilna skupina na položaju 5’ (C-5) šećera pentoze. Ovisno o šećeru razlikuju se ribonukleotidi koji ulaze u sastav RNA i deoksiribonukleotidi koji ulaze u sastav DNA.
Nukleozid esterificiran fosfornom kiselinom čini nukleotid.
U esterifikaciju fosfornom kiselinom najčešće stupa
hidroksilna skupina na položaju 5’ (C-5) šećera pentoze.
Ovisno o šećeru razlikuju se ribonukleotidi koji ulaze u sastav RNA
i deoksiribonukleotidi koji ulaze u sastav DNA.
Problemski zadatak
Koristeći rotirajući trodimenzijski model molekule adenozin-monofosfata (AMP) uočite N-glikozidnu i fosfoestersku vezu. Prisjetite se da se adenozin javlja i kao 5’-difosfat (ADP) te 5’-trifosfat (ATP) te na osnovi strukture molekule AMP-a nacrtajte strukture ADP-a i ATP-a te napišite kemijsku jednadžbu reakcije pretvorba ATP u ADP koja je glavni izvor energije u biološkim procesima.
Koristeći rotirajući trodimenzijski model molekule adenozin-monofosfata (AMP)
uočite N-glikozidnu i fosfoestersku vezu.
Prisjetite se da se adenozin javlja i kao 5’-difosfat (ADP) te 5’-trifosfat (ATP).
Na osnovi strukture molekule AMP-a nacrtajte strukture ADP-a i ATP-a.
Zatim napišite kemijsku jednadžbu reakcije pretvorba ATP u ADP
koja je glavni izvor energije u biološkim procesima.
6083
-OEChem-03042008593D
37 39 0 1 0 0 0 0 0999 V2000
4.4798 1.6292 0.0623 P 0 0 0 0 0 0 0 0 0 0 0 0
1.0170 -0.7489 1.0535 O 0 0 0 0 0 0 0 0 0 0 0 0
-0.7355 -2.8912 -1.2399 O 0 0 0 0 0 0 0 0 0 0 0 0
1.2625 -3.7185 0.4059 O 0 0 0 0 0 0 0 0 0 0 0 0
3.5092 0.4657 0.6332 O 0 0 0 0 0 0 0 0 0 0 0 0
3.6381 2.2634 -1.1644 O 0 0 0 0 0 0 0 0 0 0 0 0
5.6477 0.7934 -0.6808 O 0 0 0 0 0 0 0 0 0 0 0 0
4.9595 2.6141 1.0880 O 0 0 0 0 0 0 0 0 0 0 0 0
-1.0832 -0.0675 0.1845 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.7183 2.0201 -0.2812 N 0 0 0 0 0 0 0 0 0 0 0 0
-3.2595 -1.1090 0.4687 N 0 0 0 0 0 0 0 0 0 0 0 0
-5.0643 0.4999 0.1363 N 0 0 0 0 0 0 0 0 0 0 0 0
-4.6558 2.7958 -0.4014 N 0 0 0 0 0 0 0 0 0 0 0 0
0.2271 -1.9392 -0.8354 C 0 0 2 0 0 0 0 0 0 0 0 0
1.5341 -2.5673 -0.3934 C 0 0 1 0 0 0 0 0 0 0 0 0
-0.1975 -1.2041 0.4267 C 0 0 1 0 0 0 0 0 0 0 0 0
2.1325 -1.4814 0.4954 C 0 0 1 0 0 0 0 0 0 0 0 0
3.0125 -0.5046 -0.2719 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.4498 -0.0704 0.2133 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.6922 1.2116 -0.1163 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.8231 1.2319 -0.0782 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.1874 1.5024 -0.1124 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.5533 -0.7255 0.4074 C 0 0 0 0 0 0 0 0 0 0 0 0
0.3998 -1.2418 -1.6633 H 0 0 0 0 0 0 0 0 0 0 0 0
2.1695 -2.8804 -1.2268 H 0 0 0 0 0 0 0 0 0 0 0 0
-0.7131 -1.8615 1.1377 H 0 0 0 0 0 0 0 0 0 0 0 0
2.6894 -1.8970 1.3428 H 0 0 0 0 0 0 0 0 0 0 0 0
2.4371 0.0070 -1.0495 H 0 0 0 0 0 0 0 0 0 0 0 0
3.8491 -1.0358 -0.7361 H 0 0 0 0 0 0 0 0 0 0 0 0
-0.8430 -3.5351 -0.5192 H 0 0 0 0 0 0 0 0 0 0 0 0
2.1174 -4.0681 0.7104 H 0 0 0 0 0 0 0 0 0 0 0 0
0.3468 1.4979 -0.2079 H 0 0 0 0 0 0 0 0 0 0 0 0
-5.2836 -1.5038 0.6014 H 0 0 0 0 0 0 0 0 0 0 0 0
-4.0036 3.5455 -0.5878 H 0 0 0 0 0 0 0 0 0 0 0 0
-5.6519 2.9671 -0.4210 H 0 0 0 0 0 0 0 0 0 0 0 0
3.9986 3.0463 -1.6326 H 0 0 0 0 0 0 0 0 0 0 0 0
6.4224 1.2765 -1.0394 H 0 0 0 0 0 0 0 0 0 0 0 0
1 5 1 0 0 0 0
1 6 1 0 0 0 0
1 7 1 0 0 0 0
1 8 2 0 0 0 0
2 16 1 0 0 0 0
2 17 1 0 0 0 0
3 14 1 0 0 0 0
3 30 1 0 0 0 0
4 15 1 0 0 0 0
4 31 1 0 0 0 0
5 18 1 0 0 0 0
6 36 1 0 0 0 0
7 37 1 0 0 0 0
9 16 1 0 0 0 0
9 19 1 0 0 0 0
9 20 1 0 0 0 0
10 20 2 0 0 0 0
10 21 1 0 0 0 0
11 19 2 0 0 0 0
11 23 1 0 0 0 0
12 22 1 0 0 0 0
12 23 2 0 0 0 0
13 22 1 0 0 0 0
13 34 1 0 0 0 0
13 35 1 0 0 0 0
14 15 1 0 0 0 0
14 16 1 0 0 0 0
14 24 1 0 0 0 0
15 17 1 0 0 0 0
15 25 1 0 0 0 0
16 26 1 0 0 0 0
17 18 1 0 0 0 0
17 27 1 0 0 0 0
18 28 1 0 0 0 0
18 29 1 0 0 0 0
19 21 1 0 0 0 0
20 32 1 0 0 0 0
21 22 2 0 0 0 0
23 33 1 0 0 0 0
M END
> <PUBCHEM_COMPOUND_CID>
6083
> <PUBCHEM_CONFORMER_RMSD>
0.8
> <PUBCHEM_CONFORMER_DIVERSEORDER>
6
56
32
2
57
27
7
39
12
16
49
24
55
11
22
40
44
34
4
13
41
35
33
15
38
14
52
50
9
19
1
23
31
48
30
10
45
21
42
46
28
20
26
3
36
51
29
58
43
37
8
59
53
17
25
47
18
5
54
> <PUBCHEM_MMFF94_PARTIAL_CHARGES>
31
1 1.51
10 -0.57
11 -0.57
12 -0.62
13 -0.9
14 0.28
15 0.28
16 0.54
17 0.28
18 0.28
19 0.11
2 -0.56
20 0.04
21 0.23
22 0.41
23 0.47
3 -0.68
30 0.4
31 0.4
32 0.15
33 0.15
34 0.4
35 0.4
36 0.5
37 0.5
4 -0.68
5 -0.55
6 -0.77
7 -0.77
8 -0.7
9 0.05
> <PUBCHEM_EFFECTIVE_ROTOR_COUNT>
5
> <PUBCHEM_PHARMACOPHORE_FEATURES>
17
1 13 cation
1 13 donor
1 2 acceptor
1 3 acceptor
1 3 donor
1 4 acceptor
1 4 donor
1 6 acceptor
1 7 acceptor
1 8 acceptor
3 11 12 23 cation
3 9 10 20 cation
3 9 11 19 cation
4 1 6 7 8 anion
5 2 14 15 16 17 rings
5 9 10 19 20 21 rings
6 11 12 19 21 22 23 rings
> <PUBCHEM_HEAVY_ATOM_COUNT>
23
> <PUBCHEM_ATOM_DEF_STEREO_COUNT>
4
> <PUBCHEM_ATOM_UDEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_DEF_STEREO_COUNT>
0
> <PUBCHEM_BOND_UDEF_STEREO_COUNT>
0
> <PUBCHEM_ISOTOPIC_ATOM_COUNT>
0
> <PUBCHEM_COMPONENT_COUNT>
1
> <PUBCHEM_CACTVS_TAUTO_COUNT>
3
> <PUBCHEM_CONFORMER_ID>
000017C300000006
> <PUBCHEM_MMFF94_ENERGY>
18.8068
> <PUBCHEM_FEATURE_SELFOVERLAP>
86.926
> <PUBCHEM_SHAPE_FINGERPRINT>
10090160 65 18261106400426352615
10498660 4 18412266116525400592
10871710 139 18196648729491249519
10906281 52 18336840732063163529
11578080 2 16444732870969910583
11796584 16 10807942535029504144
12173636 292 18267861868992989358
12403259 118 18335687326357569576
12788726 201 17248940174483495810
13583140 156 17242708932328919802
14123255 52 18412542141467758668
14341114 328 17240481442225211528
14528608 73 18413666902986942853
1454969 45 18340486794109683591
14787075 74 18271804678808628339
14790565 3 18340210781624738521
15196674 1 18408604734072274289
15375358 24 18266175029383031003
15961568 22 18041000609259255197
1813 80 13326571835244678938
19591789 44 18123471841385287593
21524375 3 18412267250845081698
22113638 7 18263081187972264268
22620623 9 16915372432217834470
23227448 37 18127126596661398908
23559900 14 18122620544491995571
2838139 119 18412819209908588364
350125 39 18336827494747337646
474 4 18041003951028108180
5104073 3 18189058603662313529
67856867 119 18263637386009840034
7064713 232 18335136535800091100
7808743 9 18194679504820095240
9709674 26 18051978018088343175
9981440 41 18333733545645390530
> <PUBCHEM_SHAPE_MULTIPOLES>
411.19
10.61
3.51
0.89
1.88
1.23
0.05
-9.03
-0.26
1.63
0.43
0.49
0.07
0.41
> <PUBCHEM_SHAPE_SELFOVERLAP>
870.833
> <PUBCHEM_SHAPE_VOLUME>
232.7
> <PUBCHEM_COORDINATE_TYPE>
2
5
10
$$$$
Nukleotidi se međusobno povezuju u polinukleotidne lance 3’→5’ fosfodiesterskom vezom. To znači da je 3’-OH skupina monosaharidne jedinice jednog nukleotida povezana preko fosfatne skupine s 5’-OH skupinom monosaharidne jedinice drugog nukleotida. Označavanje smjera polinukleotidnog lanca 5’→3’ upućuje na redoslijed čitanja baza, a redoslijed nuklotida u lancu naziva se primarnom strukturom lanca ili sekvencijom.
Nukleotidi se međusobno povezuju u polinukleotidne lance 3’→5’ fosfodiesterskom vezom.
To znači da je 3’-OH skupina monosaharidne jedinice jednog nukleotida povezana
preko fosfatne skupine s 5’-OH skupinom monosaharidne jedinice drugog nukleotida.
Označavanje smjera polinukleotidnog lanca 5’→3’ upućuje na redoslijed čitanja baza.
Redoslijed nuklotida u lancu naziva se primarnom strukturom lanca ili sekvencijom.
Deoksiribonukleinska kiselina
Molekula DNA građena je od dva polinukleotidna lanca koji su spiralno obavijeni jedan oko drugoga. Svaki polinukleotidni lanac tvore nukleotidi, a svaki nukleotid je građen od tri dijela: šećera 2-deoksi-D-riboze, fosfatne skupine i dušične baze. U molekuli DNA razlikujemo četiri dušične baze: adenin (A), gvanin (G), citozin (C) i timin (T). Nukleotidi su međusobno povezani u polinukleotidne lance kovalentnim vezama tako da se fosfatna skupina jednog nukleotida veže na 2-deoksi-D-ribozu susjednog nukleotida.
Sekundarna struktura DNA, odnosno struktura polinukleotidnog lanca u prostoru, uspješno je riješena polovicom 20. stoljeća.
Molekula DNA građena je od dva polinukleotidna lanca koji su spiralno obavijeni jedan oko drugoga.
Svaki polinukleotidni lanac tvore nukleotidi.
Svaki nukleotid je građen od tri dijela:
- šećera 2-deoksi-D-riboze
- fosfatne skupine
- dušične baze.
U molekuli DNA razlikujemo četiri dušične baze: adenin (A), gvanin (G), citozin (C) i timin (T).
Nukleotidi su međusobno povezani u polinukleotidne lance kovalentnim vezama.
Fosfatna skupina jednog nukleotida se veže na 2-deoksi-D-ribozu susjednog nukleotida.
Sekundarna struktura DNA, odnosno struktura polinukleotidnog lanca u prostoru, uspješno je riješena polovicom 20. stoljeća.
Dva lanca molekule DNA međusobno su povezana vodikovim vezama. Vodikove veze ostvaruju se između komplementarnih parova baza. Komplementarne parove baza čine adenin i timin koji se međusobno spajaju dvjema vodikovim vezama odnosno citozin i gvanin trima vodikovim vezama.
Dva lanca molekule DNA međusobno su povezana vodikovim vezama.
Vodikove veze ostvaruju se između komplementarnih parova baza.
Komplementarne parove baza čine adenin i timin.
Adenin i timin se međusobno spajaju dvjema vodikovim vezama odnosno citozin i gvanin trima vodikovim vezama.
Lanci su međusobno komplementarni, što znači da se adenin jednog lanca uvijek veže s timinom drugog lanca, a citozin jednog lanca se uvijek veže s gvaninom drugog lanca. Zbog ovakvog povezivanja lanci se u dvostrukoj uzvojnici DNA omataju jedan oko drugog antiparalelno (u suprotnim smjerovima), odnosno u smjerovima 3’[latex]\longrightarrow [/latex]5’ i 5’[latex]\longrightarrow [/latex]3’.
Lanci su međusobno komplementarni.
To znači da se adenin jednog lanca uvijek veže s timinom drugog lanca.
Citozin jednog lanca se uvijek veže s gvaninom drugog lanca.
Zbog ovakvog povezivanja lanci se u dvostrukoj uzvojnici DNA omataju jedan oko drugog antiparalelno (u suprotnim smjerovima).
Odnosno u smjerovima 3’[latex]\longrightarrow [/latex]5’ i 5’[latex]\longrightarrow [/latex]3’.
Na rotirajućem modelu dijela molekule DNA proučite prostornu građu dvostruke uzvojnice.
Dio molekule DNA
Pogledajte animaciju koja prikazuje proces udvostručenja molekule DNA.
Replikacija molekule DNA
Proces udvostručenja molekule DNA započinje odmatanjem dvostruke uzvojnice i razdvajanjem lanaca. Razdvajanje ‘’roditeljskih’’ i sinteza novih lanaca teku gotovo istovremeno, a mjesto istodobnog odmatanja i sinteze naziva se replikacijskim rašljama. Replikacija molekule DNA je semikonzervativna, što znači da je novonastala molekula DNA uvijek sastavljena od jednog starog, očuvanog lanca i od jednog novog.
Proces udvostručenja molekule DNA započinje odmatanjem dvostruke uzvojnice i razdvajanjem lanaca.
Razdvajanje ‘’roditeljskih’’ i sinteza novih lanaca teku gotovo istovremeno.
Mjesto istodobnog odmatanja i sinteze naziva se replikacijskim rašljama.
Replikacija molekule DNA je semikonzervativna.
To znači da je novonastala molekula DNA uvijek sastavljena od jednog starog, očuvanog lanca i od jednog novog.
Problemski zadatak
Obrazložite zašto je važno da su nukleotidi u jednom lancu vezani čvrstim, kovalentnim vezama preko šećera deoksiriboze i fosfata, a zašto su nukleotidi nasuprotnih lanaca vezani slabijim vodikovim vezama preko dušičnih baza.
Oštećene molekule DNA popravljaju enzimi. DNA trpi mnogo oštećanja zbog utjecaja ionizirajućeg zračenja, djelovanja UV svjetlosti i različitih kemikalija. Pritom se baze mogu promijeniti ili izgubiti, a fosfodiesterske veze pokidati. Oštećenja je moguće popraviti zato što oba lanca sadrže genetičku informaciju, a informacija koja se izgubi na jednom lancu, ostaje sačuvana na drugom.
DNA trpi mnogo oštećanja zbog utjecaja ionizirajućeg zračenja, djelovanja UV svjetlosti i različitih kemikalija.
Pritom se baze mogu promijeniti ili izgubiti, a fosfodiesterske veze pokidati.
Oštećenja je moguće popraviti zato što oba lanca sadrže genetičku informaciju.
Informacija koja se izgubi na jednom lancu, ostaje sačuvana na drugom.
Molekula DNA ima sposobnost da kopira samu sebe, odnosno da se samoumnožava (autoreplicira), a što je od temeljne važnosti za njenu ulogu nasljedne tvari.
Replikacija (lat. replicatio – udvostručim) molekule DNA biološki je proces u kojem iz jedne molekule DNA nastaju dvije identične kopije djelovanjem specifičnih enzima. Svojstvo replikacije molekule DNA proizlazi iz njezine dvolančane strukture i činjenice da su polinukleotidni lanci svake molekule DNA komplementarni. U svakom pojedinom nizu nukleotida jednog lanca molekule DNA zapisana je nasljedna uputa, a drugi lanac sadrži njezin negativ odnosno kalup na temelju kojeg je moguće ponovo dobiti točan, nasljedni niz.
Molekula DNA ima sposobnost da kopira samu sebe, odnosno da se samoumnožava (autoreplicira).
To je od temeljne važnosti za njenu ulogu nasljedne tvari.
Replikacija (lat. replicatio – udvostručim) molekule DNA biološki je proces
u kojem iz jedne molekule DNA nastaju dvije identične kopije djelovanjem specifičnih enzima.
Svojstvo replikacije molekule DNA proizlazi iz njezine dvolančane strukture.
Proizlazi i iz činjenice da su polinukleotidni lanci svake molekule DNA komplementarni.
U svakom pojedinom nizu nukleotida jednog lanca molekule DNA zapisana je nasljedna uputa.
Drugi lanac sadrži njezin negativ odnosno kalup na temelju kojeg je moguće ponovo dobiti točan, nasljedni niz.
Ribonukleinska kiselina
Molekula RNA građena je od jednog polinukleotidnog lanca i znatno je kraća od DNA. Polinukleotidni lanac tvore nukleotidi, a svaki nukleotid je građen od tri dijela: šećera D-riboze, fosfatne skupine i dušične baze. U molekuli RNA razlikujemo četiri dušične baze: adenin (A), gvanin (G), citozin (C) i uracil (U). Nukleotidi su međusobno povezani u polinukleotidne lance kovalentnim vezama tako da se fosfatna skupina jednog nukleotida veže na D-ribozu susjednog nukleotida.
Molekula RNA građena je od jednog polinukleotidnog lanca i znatno je kraća od DNA.
Polinukleotidni lanac tvore nukleotidi.
Svaki nukleotid je građen od tri dijela: šećera D-riboze, fosfatne skupine i dušične baze.
U molekuli RNA razlikujemo četiri dušične baze:
- adenin (A),
- gvanin (G),
- citozin (C) i
- uracil (U).
Nukleotidi su međusobno povezani u polinukleotidne lance kovalentnim vezama.
Fosfatna skupina jednog nukleotida veže na D-ribozu susjednog nukleotida.
Postoje tri različite vrste RNA koje se razlikuju prema strukturi i funkciji: glasnička ili mRNA (eng. messenger – glasnik), transportna (prijenosna) ili tRNA i ribosomska ili rRNA. Sva tri oblika RNA uključena su u proces biosinteze proteina. Biosinteza proteina događa se u dva koraka, koje nazivamo transkripcija (prepisivanje) i translacija (prevođenje). Uputa za sekvenciju aminokiselina u proteinima zapisana je u obliku slijeda nukleotida u molekuli DNA koja se nalazi u staničnoj jezgri. Genetičku poruku s molekule DNA, u citoplazmu gdje se odvija sinteza proteina, prenosi glasnička RNA. Svakom genu odgovara zasebna molekula mRNA. Sinteza mRNA provodi se u jezgri stanice po načelima komplementarnosti baza, procesom koji se naziva transkripcija (prepisivanje). U procesu transkripcije na mjesto timina u RNA dolazi uracil. Transkripciju kataliziraju specifični enzimi, a samo jedan lanac DNA služi kao kalup za prijepis.
Postoje tri različite vrste RNA koje se razlikuju prema strukturi i funkciji:
- glasnička ili mRNA (eng. messenger – glasnik),
- transportna (prijenosna) ili tRNA i
- ribosomska ili rRNA.
Sva tri oblika RNA uključena su u proces biosinteze proteina.
Biosinteza proteina događa se u dva koraka.
Nazivamo ih transkripcija (prepisivanje) i translacija (prevođenje).
Uputa za sekvenciju aminokiselina u proteinima zapisana je u obliku slijeda nukleotida
u molekuli DNA koja se nalazi u staničnoj jezgri.
Genetičku poruku s molekule DNA, prenosi glasnička RNA u citoplazmu gdje se odvija sinteza proteina.
Svakom genu odgovara zasebna molekula mRNA.
Sinteza mRNA provodi se u jezgri stanice po načelima komplementarnosti baza.
Taj proceses se naziva transkripcija (prepisivanje).
U procesu transkripcije na mjesto timina u RNA dolazi uracil.
Transkripciju kataliziraju specifični enzimi.
Samo jedan lanac DNA služi kao kalup za prijepis.
Transkripcija
U molekuli DNA jednu aminokiselinu određuju tri baze i one čine triplet baza. Triplet baza u molekuli DNA naziva se genetički kod, a triplet baza u mRNA koja nastaje transkripcijom i komplementarna je kodu naziva se kodon.
Kodon jednoznačno određuje aminokiselinu potrebnu za sintezu proteina. S četiri različite baze mogu se načiniti 64 tripletne kombinacije. Od toga, 61 kodon služi za kodiranje 20 različitih aminokiselina. Tri kodona su besmislena i nazivaju se STOP kodoni, a to su UAA, UAG i UGA. Sinteza proteina započinje uvijek sa START kodonom, koji je ujedno i šifra za aminokiselinu metionin (Met). Signal za kraj sinteze proteina jedan je od triju STOP kodona na molekuli mRNA jer STOP kodoni nemaju komplementarne antikodone na tRNA te na taj način zaustavljaju daljnje vezanje aminokiselina.
Genetički kod je univerzalan za sva živa bića. Pojava da više kodona određuje jednu aminokiselinu osigurava stabilnost genetičkog materijala, jer pogreške koje nastaju tijekom replikacije ili transkripcije nuždno ne dovode do zamjene aminokiseline u polipeptidu.
Kako se događa proces biosinteze proteina pročitajte u poglavlju ‘’Kako se čita genetički kod?’’ na mrežnom mjestu 2.
U molekuli DNA jednu aminokiselinu određuju tri baze i one čine triplet baza.
Triplet baza u molekuli DNA naziva se genetički kod.
Triplet baza u mRNA koja nastaje transkripcijom i komplementarna je kodu naziva se kodon.
Kodon jednoznačno određuje aminokiselinu potrebnu za sintezu proteina.
S četiri različite baze mogu se načiniti 64 tripletne kombinacije.
Od toga, 61 kodon služi za kodiranje 20 različitih aminokiselina.
Tri kodona su besmislena i nazivaju se STOP kodoni.
To su UAA, UAG i UGA.
Sinteza proteina započinje uvijek sa START kodonom.
To je ujedno i šifra za aminokiselinu metionin (Met).
Signal za kraj sinteze proteina jedan je od triju STOP kodona na molekuli mRNA.
To je zato jer STOP kodoni nemaju komplementarne antikodone na tRNA.
Na taj način zaustavljaju daljnje vezanje aminokiselina.
Genetički kod je univerzalan za sva živa bića.
Pojava da više kodona određuje jednu aminokiselinu osigurava stabilnost genetičkog materijala.
To je zato jer pogreške koje nastaju tijekom replikacije ili transkripcije nužno ne dovode do zamjene aminokiseline u polipeptidu.
Kako se događa proces biosinteze proteina pročitajte u poglavlju ‘’Kako se čita genetički kod?’’ na mrežnom mjestu 2.
mRNA je komplementarna lancu kalupu DNA na kojem nastaje, te ona dalje nosi informaciju u obliku kodona u citoplazmu. U citoplazmi se nalaze preostala dva oblika molekule RNA: tRNA i mRNA.
Transportna (prijenosna) tRNA ima funkciju prijenosa odgovarajuće aminokiseline do ribosoma, mjesta biosinteze bjelančevina. Postoji najmanje 20 različitih tRNA, po jedna za svaku aminokiselinu, a sve su slične u osnovnoj strukturi (poput lista djeteline). Jedan nespareni kraj ove molekule sadrži triplet nukleotida ili antikodon koji je komplementaran jednom ili više kodona koje nosi mRNA. Drugi nespareni kraj molekule tRNA nosi mjesto za prihvaćanje odgovarajuće aminokiseline.
mRNA je komplementarna lancu kalupu DNA na kojem nastaje.
Ona dalje nosi informaciju u obliku kodona u citoplazmu.
U citoplazmi se nalaze preostala dva oblika molekule RNA: tRNA i mRNA.
Transportna (prijenosna) tRNA ima funkciju prijenosa odgovarajuće aminokiseline do ribosoma, mjesta biosinteze bjelančevina.
Postoji najmanje 20 različitih tRNA, po jedna za svaku aminokiselinu.
Sve su slične u osnovnoj strukturi (poput lista djeteline).
Jedan nespareni kraj ove molekule sadrži triplet nukleotida ili antikodon
koji je komplementaran jednom ili više kodona koje nosi mRNA.
Drugi nespareni kraj molekule tRNA nosi mjesto za prihvaćanje odgovarajuće aminokiseline.
Rotirajući trodimenzijski model tRNA prikazuje tercijarnu strukturu tRNA koja ima oblik slova L, a određena je metodom rentgenske strukturne analize.
HEADER T-RNA 12-APR-78 4TNA
TITLE FURTHER REFINEMENT OF THE STRUCTURE OF YEAST T-RNA-PHE
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: TRNAPHE;
COMPND 3 CHAIN: A
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
SOURCE 3 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 4 ORGANISM_TAXID: 4932
KEYWDS T-RNA, SINGLE STRAND, LOOPS
EXPDTA X-RAY DIFFRACTION
AUTHOR B.E.HINGERTY,R.S.BROWN,A.JACK
REVDAT 5 13-JUL-11 4TNA 1 VERSN
REVDAT 4 25-AUG-09 4TNA 1 SOURCE
REVDAT 3 24-FEB-09 4TNA 1 VERSN
REVDAT 2 01-APR-03 4TNA 1 JRNL
REVDAT 1 12-APR-78 4TNA 0
SPRSDE 17-MAY-78 4TNA 3TNA
JRNL AUTH B.HINGERTY,R.S.BROWN,A.JACK
JRNL TITL FURTHER REFINEMENT OF THE STRUCTURE OF YEAST TRNAPHE.
JRNL REF J.MOL.BIOL. V. 124 523 1978
JRNL REFN ISSN 0022-2836
JRNL PMID 361973
JRNL DOI 10.1016/0022-2836(78)90185-7
REMARK 1
REMARK 1 REFERENCE 1
REMARK 1 AUTH A.JACK,M.LEVITT
REMARK 1 TITL REFINEMENT OF LARGE STRUCTURES BY SIMULTANEOUS MINIMIZATION
REMARK 1 TITL 2 OF ENERGY AND R FACTOR
REMARK 1 REF ACTA CRYSTALLOGR.,SECT.A V. 34 931 1978
REMARK 1 REFN ISSN 0108-7673
REMARK 1 REFERENCE 2
REMARK 1 AUTH A.JACK,J.E.LADNER,D.RHODES,R.S.BROWN,A.KLUG
REMARK 1 TITL A CRYSTALLOGRAPHIC STUDY OF METAL-BINDING TO YEAST
REMARK 1 TITL 2 PHENYLALANINE TRANSFER RNA
REMARK 1 REF J.MOL.BIOL. V. 111 315 1977
REMARK 1 REFN ISSN 0022-2836
REMARK 1 REFERENCE 3
REMARK 1 AUTH A.JACK,J.E.LADNER,A.KLUG
REMARK 1 TITL CRYSTALLOGRAPHIC REFINEMENT OF YEAST PHENYLALANINE TRANSFER
REMARK 1 TITL 2 RNA AT 2.5 ANGSTROMS RESOLUTION
REMARK 1 REF J.MOL.BIOL. V. 108 619 1976
REMARK 1 REFN ISSN 0022-2836
REMARK 1 REFERENCE 4
REMARK 1 AUTH J.E.LADNER,A.JACK,J.D.ROBERTUS,R.S.BROWN,D.RHODES,
REMARK 1 AUTH 2 B.F.C.CLARK,A.KLUG
REMARK 1 TITL ATOMIC COORDINATES FOR YEAST PHENYLALANINE T-RNA
REMARK 1 REF NUCLEIC ACIDS RES. V. 2 1629 1975
REMARK 1 REFN ISSN 0305-1048
REMARK 1 REFERENCE 5
REMARK 1 AUTH J.D.ROBERTUS,J.E.LADNER,J.T.FINCH,D.RHODES,R.S.BROWN,
REMARK 1 AUTH 2 B.F.C.CLARK,A.KLUG
REMARK 1 TITL STRUCTURE OF YEAST PHENYLALANINE T-RNA AT 3 ANGSTROMS
REMARK 1 TITL 2 RESOLUTION
REMARK 1 REF NATURE V. 250 546 1974
REMARK 1 REFN ISSN 0028-0836
REMARK 1 REFERENCE 6
REMARK 1 REF ATLAS OF PROTEIN SEQUENCE V. 5 347 1972
REMARK 1 REF 2 AND STRUCTURE (DATA SECTION)
REMARK 1 PUBL NATIONAL BIOMEDICAL RESEARCH FOUNDATION, SILVER SPRING,MD.
REMARK 1 REFN
REMARK 2
REMARK 2 RESOLUTION. 2.50 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : JACK-LEVITT
REMARK 3 AUTHORS : JACK,LEVITT
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : NULL
REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL
REMARK 3 DATA CUTOFF HIGH (ABS(F)) : NULL
REMARK 3 DATA CUTOFF LOW (ABS(F)) : NULL
REMARK 3 COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK 3 NUMBER OF REFLECTIONS : NULL
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 CROSS-VALIDATION METHOD : NULL
REMARK 3 FREE R VALUE TEST SET SELECTION : NULL
REMARK 3 R VALUE (WORKING SET) : NULL
REMARK 3 FREE R VALUE : NULL
REMARK 3 FREE R VALUE TEST SET SIZE (%) : NULL
REMARK 3 FREE R VALUE TEST SET COUNT : NULL
REMARK 3 ESTIMATED ERROR OF FREE R VALUE : NULL
REMARK 3
REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.
REMARK 3 TOTAL NUMBER OF BINS USED : NULL
REMARK 3 BIN RESOLUTION RANGE HIGH (A) : NULL
REMARK 3 BIN RESOLUTION RANGE LOW (A) : NULL
REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK 3 REFLECTIONS IN BIN (WORKING SET) : NULL
REMARK 3 BIN R VALUE (WORKING SET) : NULL
REMARK 3 BIN FREE R VALUE : NULL
REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : NULL
REMARK 3 BIN FREE R VALUE TEST SET COUNT : NULL
REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK 3
REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK 3 PROTEIN ATOMS : 0
REMARK 3 NUCLEIC ACID ATOMS : 1652
REMARK 3 HETEROGEN ATOMS : 4
REMARK 3 SOLVENT ATOMS : 0
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : NULL
REMARK 3 B22 (A**2) : NULL
REMARK 3 B33 (A**2) : NULL
REMARK 3 B12 (A**2) : NULL
REMARK 3 B13 (A**2) : NULL
REMARK 3 B23 (A**2) : NULL
REMARK 3
REMARK 3 ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM LUZZATI PLOT (A) : NULL
REMARK 3 ESD FROM SIGMAA (A) : NULL
REMARK 3 LOW RESOLUTION CUTOFF (A) : NULL
REMARK 3
REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : NULL
REMARK 3 ESD FROM C-V SIGMAA (A) : NULL
REMARK 3
REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES.
REMARK 3 BOND LENGTHS (A) : NULL
REMARK 3 BOND ANGLES (DEGREES) : NULL
REMARK 3 DIHEDRAL ANGLES (DEGREES) : NULL
REMARK 3 IMPROPER ANGLES (DEGREES) : NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL MODEL : NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA
REMARK 3 MAIN-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 MAIN-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3
REMARK 3 NCS MODEL : NULL
REMARK 3
REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT
REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL
REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL
REMARK 3
REMARK 3 PARAMETER FILE 1 : NULL
REMARK 3 TOPOLOGY FILE 1 : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 4TNA COMPLIES WITH FORMAT V. 3.15, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : NULL
REMARK 200 TEMPERATURE (KELVIN) : NULL
REMARK 200 PH : NULL
REMARK 200 NUMBER OF CRYSTALS USED : NULL
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : NULL
REMARK 200 RADIATION SOURCE : NULL
REMARK 200 BEAMLINE : NULL
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : NULL
REMARK 200 WAVELENGTH OR RANGE (A) : NULL
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : NULL
REMARK 200 DETECTOR MANUFACTURER : NULL
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200 DATA SCALING SOFTWARE : NULL
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : NULL
REMARK 200 RESOLUTION RANGE HIGH (A) : NULL
REMARK 200 RESOLUTION RANGE LOW (A) : NULL
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : NULL
REMARK 200 DATA REDUNDANCY : NULL
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : NULL
REMARK 200 COMPLETENESS FOR SHELL (%) : NULL
REMARK 200 DATA REDUNDANCY IN SHELL : NULL
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: NULL
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 48.31
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.38
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: NULL
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X,Y+1/2,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 16.70007
REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 G A 1 C6 G A 1 N1 -0.044
REMARK 500 G A 1 N7 G A 1 C8 0.070
REMARK 500 C A 2 C5 C A 2 C6 0.050
REMARK 500 G A 3 N7 G A 3 C8 0.081
REMARK 500 G A 4 C6 G A 4 N1 -0.059
REMARK 500 G A 4 N7 G A 4 C8 0.081
REMARK 500 A A 5 N3 A A 5 C4 0.040
REMARK 500 A A 5 N7 A A 5 C8 0.075
REMARK 500 U A 6 C5 U A 6 C6 0.058
REMARK 500 U A 7 C2 U A 7 N3 -0.053
REMARK 500 U A 7 N3 U A 7 C4 -0.061
REMARK 500 U A 7 C5 U A 7 C6 0.066
REMARK 500 U A 8 N1 U A 8 C6 -0.060
REMARK 500 U A 8 C2 U A 8 N3 -0.049
REMARK 500 U A 8 N3 U A 8 C4 -0.055
REMARK 500 A A 9 N7 A A 9 C8 0.069
REMARK 500 C A 11 N1 C A 11 C6 -0.050
REMARK 500 U A 12 N3 U A 12 C4 -0.058
REMARK 500 C A 13 N1 C A 13 C2 -0.065
REMARK 500 C A 13 N1 C A 13 C6 -0.051
REMARK 500 A A 14 N7 A A 14 C8 0.061
REMARK 500 G A 15 C6 G A 15 N1 -0.049
REMARK 500 G A 15 N7 G A 15 C8 0.061
REMARK 500 G A 18 C6 G A 18 N1 -0.065
REMARK 500 G A 18 N7 G A 18 C8 0.092
REMARK 500 G A 19 N1 G A 19 C2 -0.078
REMARK 500 G A 19 C4 G A 19 C5 -0.070
REMARK 500 G A 19 C6 G A 19 N1 -0.122
REMARK 500 G A 19 N7 G A 19 C8 0.043
REMARK 500 G A 19 C8 G A 19 N9 -0.085
REMARK 500 G A 20 N3 G A 20 C4 0.046
REMARK 500 G A 20 C6 G A 20 N1 -0.055
REMARK 500 G A 20 N7 G A 20 C8 0.056
REMARK 500 A A 21 N7 A A 21 C8 0.065
REMARK 500 G A 22 C6 G A 22 N1 -0.070
REMARK 500 G A 22 N7 G A 22 C8 0.074
REMARK 500 A A 23 N3 A A 23 C4 0.039
REMARK 500 A A 23 N7 A A 23 C8 0.063
REMARK 500 G A 24 C6 G A 24 N1 -0.060
REMARK 500 G A 24 N7 G A 24 C8 0.068
REMARK 500 C A 25 N1 C A 25 C2 -0.088
REMARK 500 C A 25 N1 C A 25 C6 -0.050
REMARK 500 C A 25 C4 C A 25 C5 -0.048
REMARK 500 C A 27 N1 C A 27 C2 -0.065
REMARK 500 C A 27 N1 C A 27 C6 -0.041
REMARK 500 C A 28 N1 C A 28 C2 -0.089
REMARK 500 C A 28 N1 C A 28 C6 -0.047
REMARK 500 C A 28 C4 C A 28 C5 -0.054
REMARK 500 C A 28 C5 C A 28 C6 0.049
REMARK 500 A A 29 N7 A A 29 C8 0.057
REMARK 500
REMARK 500 THIS ENTRY HAS 123 BOND DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 G A 1 C6 - N1 - C2 ANGL. DEV. = -4.0 DEGREES
REMARK 500 G A 1 C2 - N3 - C4 ANGL. DEV. = 8.4 DEGREES
REMARK 500 G A 1 N3 - C4 - C5 ANGL. DEV. = -8.1 DEGREES
REMARK 500 G A 1 C5 - C6 - N1 ANGL. DEV. = 7.9 DEGREES
REMARK 500 G A 1 N7 - C8 - N9 ANGL. DEV. = -4.2 DEGREES
REMARK 500 G A 1 N3 - C4 - N9 ANGL. DEV. = 6.2 DEGREES
REMARK 500 G A 1 C5 - C6 - O6 ANGL. DEV. = -8.9 DEGREES
REMARK 500 C A 2 N3 - C4 - C5 ANGL. DEV. = -2.8 DEGREES
REMARK 500 G A 3 O5' - C5' - C4' ANGL. DEV. = -5.1 DEGREES
REMARK 500 G A 3 C4' - C3' - C2' ANGL. DEV. = -6.6 DEGREES
REMARK 500 G A 3 C2 - N3 - C4 ANGL. DEV. = 7.9 DEGREES
REMARK 500 G A 3 N3 - C4 - C5 ANGL. DEV. = -7.9 DEGREES
REMARK 500 G A 3 C5 - C6 - N1 ANGL. DEV. = 7.7 DEGREES
REMARK 500 G A 3 N7 - C8 - N9 ANGL. DEV. = -4.8 DEGREES
REMARK 500 G A 3 C8 - N9 - C4 ANGL. DEV. = 2.6 DEGREES
REMARK 500 G A 3 N3 - C4 - N9 ANGL. DEV. = 6.1 DEGREES
REMARK 500 G A 3 C5 - C6 - O6 ANGL. DEV. = -9.6 DEGREES
REMARK 500 G A 4 N9 - C1' - C2' ANGL. DEV. = -7.0 DEGREES
REMARK 500 G A 4 C2 - N3 - C4 ANGL. DEV. = 8.0 DEGREES
REMARK 500 G A 4 N3 - C4 - C5 ANGL. DEV. = -8.8 DEGREES
REMARK 500 G A 4 C5 - C6 - N1 ANGL. DEV. = 7.7 DEGREES
REMARK 500 G A 4 N7 - C8 - N9 ANGL. DEV. = -5.1 DEGREES
REMARK 500 G A 4 C8 - N9 - C4 ANGL. DEV. = 2.8 DEGREES
REMARK 500 G A 4 N3 - C4 - N9 ANGL. DEV. = 6.7 DEGREES
REMARK 500 G A 4 C5 - C6 - O6 ANGL. DEV. = -8.6 DEGREES
REMARK 500 A A 5 O5' - C5' - C4' ANGL. DEV. = -5.5 DEGREES
REMARK 500 A A 5 C4' - C3' - C2' ANGL. DEV. = -6.1 DEGREES
REMARK 500 A A 5 N1 - C2 - N3 ANGL. DEV. = -8.0 DEGREES
REMARK 500 A A 5 C2 - N3 - C4 ANGL. DEV. = 9.0 DEGREES
REMARK 500 A A 5 N3 - C4 - C5 ANGL. DEV. = -6.8 DEGREES
REMARK 500 A A 5 N7 - C8 - N9 ANGL. DEV. = -5.3 DEGREES
REMARK 500 A A 5 C8 - N9 - C4 ANGL. DEV. = 3.1 DEGREES
REMARK 500 A A 5 N3 - C4 - N9 ANGL. DEV. = 4.9 DEGREES
REMARK 500 U A 6 N1 - C2 - N3 ANGL. DEV. = 5.6 DEGREES
REMARK 500 U A 6 C2 - N3 - C4 ANGL. DEV. = -4.9 DEGREES
REMARK 500 U A 6 C5 - C4 - O4 ANGL. DEV. = -6.8 DEGREES
REMARK 500 U A 7 N1 - C2 - N3 ANGL. DEV. = 6.6 DEGREES
REMARK 500 U A 7 C2 - N3 - C4 ANGL. DEV. = -5.7 DEGREES
REMARK 500 U A 7 N3 - C4 - C5 ANGL. DEV. = 4.8 DEGREES
REMARK 500 U A 7 C5 - C6 - N1 ANGL. DEV. = -3.8 DEGREES
REMARK 500 U A 7 C5 - C4 - O4 ANGL. DEV. = -5.4 DEGREES
REMARK 500 U A 8 N1 - C2 - N3 ANGL. DEV. = 5.2 DEGREES
REMARK 500 U A 8 C2 - N3 - C4 ANGL. DEV. = -5.6 DEGREES
REMARK 500 U A 8 N3 - C4 - C5 ANGL. DEV. = 4.5 DEGREES
REMARK 500 U A 8 C5 - C4 - O4 ANGL. DEV. = -8.6 DEGREES
REMARK 500 A A 9 N1 - C2 - N3 ANGL. DEV. = -8.0 DEGREES
REMARK 500 A A 9 C2 - N3 - C4 ANGL. DEV. = 9.1 DEGREES
REMARK 500 A A 9 N3 - C4 - C5 ANGL. DEV. = -7.0 DEGREES
REMARK 500 A A 9 N7 - C8 - N9 ANGL. DEV. = -5.4 DEGREES
REMARK 500 A A 9 C8 - N9 - C4 ANGL. DEV. = 3.3 DEGREES
REMARK 500
REMARK 500 THIS ENTRY HAS 333 ANGLE DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI RMS TYPE
REMARK 500 G A 1 0.07 SIDE CHAIN
REMARK 500 C A 2 0.12 SIDE CHAIN
REMARK 500 G A 3 0.06 SIDE CHAIN
REMARK 500 A A 5 0.12 SIDE CHAIN
REMARK 500 U A 6 0.12 SIDE CHAIN
REMARK 500 U A 8 0.14 SIDE CHAIN
REMARK 500 U A 12 0.09 SIDE CHAIN
REMARK 500 C A 13 0.08 SIDE CHAIN
REMARK 500 G A 15 0.09 SIDE CHAIN
REMARK 500 G A 18 0.10 SIDE CHAIN
REMARK 500 G A 19 0.10 SIDE CHAIN
REMARK 500 G A 20 0.07 SIDE CHAIN
REMARK 500 A A 21 0.15 SIDE CHAIN
REMARK 500 A A 23 0.07 SIDE CHAIN
REMARK 500 G A 24 0.10 SIDE CHAIN
REMARK 500 C A 25 0.10 SIDE CHAIN
REMARK 500 C A 27 0.12 SIDE CHAIN
REMARK 500 C A 28 0.11 SIDE CHAIN
REMARK 500 A A 29 0.08 SIDE CHAIN
REMARK 500 G A 30 0.10 SIDE CHAIN
REMARK 500 U A 33 0.12 SIDE CHAIN
REMARK 500 A A 38 0.13 SIDE CHAIN
REMARK 500 U A 41 0.10 SIDE CHAIN
REMARK 500 G A 42 0.07 SIDE CHAIN
REMARK 500 G A 43 0.07 SIDE CHAIN
REMARK 500 A A 44 0.09 SIDE CHAIN
REMARK 500 U A 47 0.07 SIDE CHAIN
REMARK 500 U A 50 0.11 SIDE CHAIN
REMARK 500 G A 51 0.14 SIDE CHAIN
REMARK 500 G A 53 0.14 SIDE CHAIN
REMARK 500 C A 56 0.06 SIDE CHAIN
REMARK 500 G A 57 0.14 SIDE CHAIN
REMARK 500 U A 59 0.08 SIDE CHAIN
REMARK 500 C A 60 0.11 SIDE CHAIN
REMARK 500 C A 61 0.09 SIDE CHAIN
REMARK 500 A A 62 0.05 SIDE CHAIN
REMARK 500 A A 64 0.08 SIDE CHAIN
REMARK 500 U A 68 0.09 SIDE CHAIN
REMARK 500 G A 71 0.07 SIDE CHAIN
REMARK 500 C A 72 0.15 SIDE CHAIN
REMARK 500 A A 73 0.07 SIDE CHAIN
REMARK 500 C A 74 0.10 SIDE CHAIN
REMARK 500 C A 75 0.09 SIDE CHAIN
REMARK 500 A A 76 0.08 SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG A 78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG A 79
DBREF 4TNA A 1 76 PDB 4TNA 4TNA 1 76
SEQRES 1 A 76 G C G G A U U U A 2MG C U C
SEQRES 2 A 76 A G H2U H2U G G G A G A G C M2G
SEQRES 3 A 76 C C A G A OMC U OMG A A YG A PSU
SEQRES 4 A 76 5MC U G G A G 7MG U C 5MC U G U
SEQRES 5 A 76 G 5MU PSU C G 1MA U C C A C A G
SEQRES 6 A 76 A A U U C G C A C C A
MODRES 4TNA 2MG A 10 G 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
MODRES 4TNA H2U A 16 U 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
MODRES 4TNA H2U A 17 U 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
MODRES 4TNA M2G A 26 G N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
MODRES 4TNA OMC A 32 C O2'-METHYLYCYTIDINE-5'-MONOPHOSPHATE
MODRES 4TNA OMG A 34 G O2'-METHYLGUANOSINE-5'-MONOPHOSPHATE
MODRES 4TNA YG A 37 G WYBUTOSINE
MODRES 4TNA PSU A 39 U PSEUDOURIDINE-5'-MONOPHOSPHATE
MODRES 4TNA 5MC A 40 C 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
MODRES 4TNA 7MG A 46 G
MODRES 4TNA 5MC A 49 C 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
MODRES 4TNA 5MU A 54 U 5-METHYLURIDINE 5'-MONOPHOSPHATE
MODRES 4TNA PSU A 55 U PSEUDOURIDINE-5'-MONOPHOSPHATE
MODRES 4TNA 1MA A 58 A
HET 2MG A 10 24
HET H2U A 16 20
HET H2U A 17 20
HET M2G A 26 25
HET OMC A 32 21
HET OMG A 34 24
HET YG A 37 39
HET PSU A 39 20
HET 5MC A 40 21
HET 7MG A 46 24
HET 5MC A 49 21
HET 5MU A 54 21
HET PSU A 55 20
HET 1MA A 58 23
HET MG A 77 1
HET MG A 78 1
HET MG A 79 1
HET MG A 80 1
HETNAM 2MG 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
HETNAM H2U 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
HETNAM M2G N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
HETNAM OMC O2'-METHYLYCYTIDINE-5'-MONOPHOSPHATE
HETNAM OMG O2'-METHYLGUANOSINE-5'-MONOPHOSPHATE
HETNAM YG WYBUTOSINE
HETNAM PSU PSEUDOURIDINE-5'-MONOPHOSPHATE
HETNAM 5MC 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
HETNAM 7MG 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
HETNAM 5MU 5-METHYLURIDINE 5'-MONOPHOSPHATE
HETNAM 1MA 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE
HETNAM MG MAGNESIUM ION
HETSYN YG Y-BASE; 1H-IMIDAZO(1,2-ALPHA)PURINE-7-BUTANOIC ACID,4,
HETSYN 2 YG 9-DIHYDRO-ALPHA-((METHOXYCARBONYL)AMINO)-4,6-DIMETHYL-
HETSYN 3 YG 9-OXO-METHYL ESTER
FORMUL 1 2MG C11 H16 N5 O8 P
FORMUL 1 H2U 2(C9 H15 N2 O9 P)
FORMUL 1 M2G C12 H18 N5 O8 P
FORMUL 1 OMC C10 H16 N3 O8 P
FORMUL 1 OMG C11 H16 N5 O8 P
FORMUL 1 YG C21 H29 N6 O12 P
FORMUL 1 PSU 2(C9 H13 N2 O9 P)
FORMUL 1 5MC 2(C10 H16 N3 O8 P)
FORMUL 1 7MG C11 H18 N5 O8 P
FORMUL 1 5MU C10 H15 N2 O9 P
FORMUL 1 1MA C11 H16 N5 O7 P
FORMUL 2 MG 4(MG 2+)
LINK P 2MG A 10 O3' A A 9 1555 1555 1.58
LINK O3' 2MG A 10 P C A 11 1555 1555 1.59
LINK P H2U A 16 O3' G A 15 1555 1555 1.57
LINK O3' H2U A 16 P H2U A 17 1555 1555 1.57
LINK O3' H2U A 17 P G A 18 1555 1555 1.62
LINK P M2G A 26 O3' C A 25 1555 1555 1.60
LINK O3' M2G A 26 P C A 27 1555 1555 1.59
LINK P OMC A 32 O3' A A 31 1555 1555 1.60
LINK O3' OMC A 32 P U A 33 1555 1555 1.61
LINK P OMG A 34 O3' U A 33 1555 1555 1.61
LINK O3' OMG A 34 P A A 35 1555 1555 1.61
LINK P YG A 37 O3' A A 36 1555 1555 1.60
LINK O3' YG A 37 P A A 38 1555 1555 1.61
LINK P PSU A 39 O3' A A 38 1555 1555 1.62
LINK O3' PSU A 39 P 5MC A 40 1555 1555 1.60
LINK O3' 5MC A 40 P U A 41 1555 1555 1.64
LINK P 7MG A 46 O3' G A 45 1555 1555 1.60
LINK O3' 7MG A 46 P U A 47 1555 1555 1.62
LINK P 5MC A 49 O3' C A 48 1555 1555 1.59
LINK O3' 5MC A 49 P U A 50 1555 1555 1.60
LINK P 5MU A 54 O3' G A 53 1555 1555 1.59
LINK O3' 5MU A 54 P PSU A 55 1555 1555 1.60
LINK O3' PSU A 55 P C A 56 1555 1555 1.59
LINK P 1MA A 58 O3' G A 57 1555 1555 1.58
LINK O3' 1MA A 58 P U A 59 1555 1555 1.61
LINK OP1 G A 19 MG MG A 79 1555 1555 2.40
LINK OP2 A A 21 MG MG A 78 1555 1555 2.32
SITE 1 AC1 2 G A 20 A A 21
SITE 1 AC2 1 G A 19
CRYST1 56.300 33.400 63.000 90.00 90.25 90.00 P 1 21 1 2
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.017760 0.000000 0.000000 0.00000
SCALE2 0.000000 0.029940 0.000000 0.00000
SCALE3 0.000070 0.000000 0.015873 0.00000
ATOM 1 OP3 G A 1 23.215 5.145 51.161 1.00 0.00 O
ATOM 2 P G A 1 24.650 4.594 51.620 1.00 0.00 P
ATOM 3 OP1 G A 1 24.810 3.219 51.082 1.00 0.00 O
ATOM 4 OP2 G A 1 25.707 5.598 51.344 1.00 0.00 O
ATOM 5 O5' G A 1 24.476 4.546 53.204 1.00 0.00 O
ATOM 6 C5' G A 1 25.156 5.525 53.978 1.00 0.00 C
ATOM 7 C4' G A 1 25.808 4.801 55.152 1.00 0.00 C
ATOM 8 O4' G A 1 24.983 3.707 55.565 1.00 0.00 O
ATOM 9 C3' G A 1 27.185 4.241 54.785 1.00 0.00 C
ATOM 10 O3' G A 1 28.130 5.240 55.163 1.00 0.00 O
ATOM 11 C2' G A 1 27.282 3.124 55.808 1.00 0.00 C
ATOM 12 O2' G A 1 27.691 3.684 57.045 1.00 0.00 O
ATOM 13 C1' G A 1 25.833 2.612 55.903 1.00 0.00 C
ATOM 14 N9 G A 1 25.681 1.623 54.832 1.00 0.00 N
ATOM 15 C8 G A 1 24.865 1.712 53.755 1.00 0.00 C
ATOM 16 N7 G A 1 25.012 0.580 52.989 1.00 0.00 N
ATOM 17 C5 G A 1 25.874 -0.248 53.697 1.00 0.00 C
ATOM 18 C6 G A 1 26.336 -1.541 53.483 1.00 0.00 C
ATOM 19 O6 G A 1 25.983 -2.159 52.466 1.00 0.00 O
ATOM 20 N1 G A 1 27.127 -2.122 54.405 1.00 0.00 N
ATOM 21 C2 G A 1 27.481 -1.468 55.532 1.00 0.00 C
ATOM 22 N2 G A 1 28.055 -2.114 56.534 1.00 0.00 N
ATOM 23 N3 G A 1 27.078 -0.243 55.747 1.00 0.00 N
ATOM 24 C4 G A 1 26.260 0.388 54.839 1.00 0.00 C
ATOM 25 P C A 2 29.640 5.301 54.591 1.00 0.00 P
ATOM 26 OP1 C A 2 30.307 6.511 55.152 1.00 0.00 O
ATOM 27 OP2 C A 2 29.605 5.142 53.117 1.00 0.00 O
ATOM 28 O5' C A 2 30.332 4.036 55.292 1.00 0.00 O
ATOM 29 C5' C A 2 30.763 4.137 56.639 1.00 0.00 C
ATOM 30 C4' C A 2 31.424 2.812 56.982 1.00 0.00 C
ATOM 31 O4' C A 2 30.483 1.753 56.828 1.00 0.00 O
ATOM 32 C3' C A 2 32.562 2.541 56.002 1.00 0.00 C
ATOM 33 O3' C A 2 33.772 3.124 56.479 1.00 0.00 O
ATOM 34 C2' C A 2 32.637 1.038 56.077 1.00 0.00 C
ATOM 35 O2' C A 2 33.390 0.643 57.211 1.00 0.00 O
ATOM 36 C1' C A 2 31.162 0.636 56.248 1.00 0.00 C
ATOM 37 N1 C A 2 30.570 0.343 54.911 1.00 0.00 N
ATOM 38 C2 C A 2 30.799 -0.845 54.338 1.00 0.00 C
ATOM 39 O2 C A 2 31.777 -1.511 54.728 1.00 0.00 O
ATOM 40 N3 C A 2 30.243 -1.143 53.141 1.00 0.00 N
ATOM 41 C4 C A 2 29.496 -0.265 52.481 1.00 0.00 C
ATOM 42 N4 C A 2 28.782 -0.652 51.425 1.00 0.00 N
ATOM 43 C5 C A 2 29.284 0.988 53.032 1.00 0.00 C
ATOM 44 C6 C A 2 29.844 1.264 54.273 1.00 0.00 C
ATOM 45 P G A 3 34.558 4.092 55.472 1.00 0.00 P
ATOM 46 OP1 G A 3 35.617 4.858 56.160 1.00 0.00 O
ATOM 47 OP2 G A 3 33.579 4.765 54.565 1.00 0.00 O
ATOM 48 O5' G A 3 35.361 3.002 54.718 1.00 0.00 O
ATOM 49 C5' G A 3 36.430 2.519 55.497 1.00 0.00 C
ATOM 50 C4' G A 3 36.785 1.211 54.865 1.00 0.00 C
ATOM 51 O4' G A 3 35.592 0.439 54.762 1.00 0.00 O
ATOM 52 C3' G A 3 37.127 1.494 53.426 1.00 0.00 C
ATOM 53 O3' G A 3 38.384 2.155 53.317 1.00 0.00 O
ATOM 54 C2' G A 3 37.054 0.044 52.956 1.00 0.00 C
ATOM 55 O2' G A 3 38.107 -0.710 53.511 1.00 0.00 O
ATOM 56 C1' G A 3 35.772 -0.434 53.651 1.00 0.00 C
ATOM 57 N9 G A 3 34.630 -0.302 52.717 1.00 0.00 N
ATOM 58 C8 G A 3 33.780 0.768 52.590 1.00 0.00 C
ATOM 59 N7 G A 3 32.895 0.502 51.557 1.00 0.00 N
ATOM 60 C5 G A 3 33.242 -0.757 51.063 1.00 0.00 C
ATOM 61 C6 G A 3 32.769 -1.512 49.984 1.00 0.00 C
ATOM 62 O6 G A 3 31.672 -1.220 49.480 1.00 0.00 O
ATOM 63 N1 G A 3 33.324 -2.722 49.729 1.00 0.00 N
ATOM 64 C2 G A 3 34.329 -3.222 50.500 1.00 0.00 C
ATOM 65 N2 G A 3 34.868 -4.421 50.223 1.00 0.00 N
ATOM 66 N3 G A 3 34.799 -2.523 51.531 1.00 0.00 N
ATOM 67 C4 G A 3 34.267 -1.271 51.817 1.00 0.00 C
ATOM 68 P G A 4 38.845 2.801 51.914 1.00 0.00 P
ATOM 69 OP1 G A 4 40.096 3.590 52.097 1.00 0.00 O
ATOM 70 OP2 G A 4 37.683 3.498 51.323 1.00 0.00 O
ATOM 71 O5' G A 4 39.194 1.500 51.045 1.00 0.00 O
ATOM 72 C5' G A 4 40.265 0.666 51.450 1.00 0.00 C
ATOM 73 C4' G A 4 40.197 -0.601 50.604 1.00 0.00 C
ATOM 74 O4' G A 4 38.950 -1.273 50.773 1.00 0.00 O
ATOM 75 C3' G A 4 40.292 -0.239 49.132 1.00 0.00 C
ATOM 76 O3' G A 4 41.675 -0.135 48.828 1.00 0.00 O
ATOM 77 C2' G A 4 39.663 -1.486 48.505 1.00 0.00 C
ATOM 78 O2' G A 4 40.590 -2.540 48.344 1.00 0.00 O
ATOM 79 C1' G A 4 38.604 -1.895 49.532 1.00 0.00 C
ATOM 80 N9 G A 4 37.351 -1.323 49.033 1.00 0.00 N
ATOM 81 C8 G A 4 36.749 -0.186 49.459 1.00 0.00 C
ATOM 82 N7 G A 4 35.590 -0.012 48.720 1.00 0.00 N
ATOM 83 C5 G A 4 35.532 -1.066 47.811 1.00 0.00 C
ATOM 84 C6 G A 4 34.556 -1.492 46.905 1.00 0.00 C
ATOM 85 O6 G A 4 33.608 -0.742 46.613 1.00 0.00 O
ATOM 86 N1 G A 4 34.787 -2.572 46.161 1.00 0.00 N
ATOM 87 C2 G A 4 35.922 -3.277 46.268 1.00 0.00 C
ATOM 88 N2 G A 4 36.180 -4.264 45.397 1.00 0.00 N
ATOM 89 N3 G A 4 36.841 -2.942 47.163 1.00 0.00 N
ATOM 90 C4 G A 4 36.644 -1.838 47.975 1.00 0.00 C
ATOM 91 P A A 5 42.128 0.884 47.695 1.00 0.00 P
ATOM 92 OP1 A A 5 43.613 1.004 47.614 1.00 0.00 O
ATOM 93 OP2 A A 5 41.299 2.111 47.812 1.00 0.00 O
ATOM 94 O5' A A 5 41.651 0.035 46.450 1.00 0.00 O
ATOM 95 C5' A A 5 42.437 -1.057 46.016 1.00 0.00 C
ATOM 96 C4' A A 5 41.635 -1.650 44.871 1.00 0.00 C
ATOM 97 O4' A A 5 40.311 -1.830 45.348 1.00 0.00 O
ATOM 98 C3' A A 5 41.473 -0.661 43.726 1.00 0.00 C
ATOM 99 O3' A A 5 42.564 -0.739 42.828 1.00 0.00 O
ATOM 100 C2' A A 5 40.323 -1.357 43.061 1.00 0.00 C
ATOM 101 O2' A A 5 40.843 -2.565 42.582 1.00 0.00 O
ATOM 102 C1' A A 5 39.448 -1.737 44.231 1.00 0.00 C
ATOM 103 N9 A A 5 38.420 -0.702 44.464 1.00 0.00 N
ATOM 104 C8 A A 5 38.423 0.272 45.424 1.00 0.00 C
ATOM 105 N7 A A 5 37.216 0.950 45.366 1.00 0.00 N
ATOM 106 C5 A A 5 36.482 0.343 44.346 1.00 0.00 C
ATOM 107 C6 A A 5 35.163 0.493 43.904 1.00 0.00 C
ATOM 108 N6 A A 5 34.295 1.168 44.636 1.00 0.00 N
ATOM 109 N1 A A 5 34.718 -0.263 42.892 1.00 0.00 N
ATOM 110 C2 A A 5 35.498 -1.178 42.310 1.00 0.00 C
ATOM 111 N3 A A 5 36.742 -1.384 42.721 1.00 0.00 N
ATOM 112 C4 A A 5 37.254 -0.626 43.760 1.00 0.00 C
ATOM 113 P U A 6 42.767 0.450 41.759 1.00 0.00 P
ATOM 114 OP1 U A 6 43.994 0.174 40.981 1.00 0.00 O
ATOM 115 OP2 U A 6 42.670 1.709 42.514 1.00 0.00 O
ATOM 116 O5' U A 6 41.522 0.371 40.752 1.00 0.00 O
ATOM 117 C5' U A 6 41.479 -0.627 39.741 1.00 0.00 C
ATOM 118 C4' U A 6 40.165 -0.455 38.978 1.00 0.00 C
ATOM 119 O4' U A 6 39.086 -0.468 39.903 1.00 0.00 O
ATOM 120 C3' U A 6 40.066 0.913 38.327 1.00 0.00 C
ATOM 121 O3' U A 6 40.808 0.975 37.109 1.00 0.00 O
ATOM 122 C2' U A 6 38.567 0.896 38.063 1.00 0.00 C
ATOM 123 O2' U A 6 38.326 -0.025 37.025 1.00 0.00 O
ATOM 124 C1' U A 6 38.007 0.277 39.351 1.00 0.00 C
ATOM 125 N1 U A 6 37.600 1.310 40.340 1.00 0.00 N
ATOM 126 C2 U A 6 36.338 1.770 40.360 1.00 0.00 C
ATOM 127 O2 U A 6 35.478 1.251 39.625 1.00 0.00 O
ATOM 128 N3 U A 6 35.959 2.694 41.269 1.00 0.00 N
ATOM 129 C4 U A 6 36.807 3.194 42.166 1.00 0.00 C
ATOM 130 O4 U A 6 36.355 3.674 43.222 1.00 0.00 O
ATOM 131 C5 U A 6 38.121 2.762 42.132 1.00 0.00 C
ATOM 132 C6 U A 6 38.495 1.800 41.193 1.00 0.00 C
ATOM 133 P U A 7 41.128 2.411 36.444 1.00 0.00 P
ATOM 134 OP1 U A 7 41.982 2.228 35.251 1.00 0.00 O
ATOM 135 OP2 U A 7 41.556 3.349 37.496 1.00 0.00 O
ATOM 136 O5' U A 7 39.741 2.907 35.857 1.00 0.00 O
ATOM 137 C5' U A 7 39.151 2.237 34.758 1.00 0.00 C
ATOM 138 C4' U A 7 37.856 2.971 34.421 1.00 0.00 C
ATOM 139 O4' U A 7 37.201 3.209 35.661 1.00 0.00 O
ATOM 140 C3' U A 7 38.181 4.350 33.843 1.00 0.00 C
ATOM 141 O3' U A 7 37.253 4.663 32.823 1.00 0.00 O
ATOM 142 C2' U A 7 37.939 5.319 34.969 1.00 0.00 C
ATOM 143 O2' U A 7 37.441 6.510 34.348 1.00 0.00 O
ATOM 144 C1' U A 7 36.824 4.578 35.717 1.00 0.00 C
ATOM 145 N1 U A 7 36.714 5.012 37.134 1.00 0.00 N
ATOM 146 C2 U A 7 35.568 5.559 37.594 1.00 0.00 C
ATOM 147 O2 U A 7 34.571 5.614 36.871 1.00 0.00 O
ATOM 148 N3 U A 7 35.452 5.971 38.843 1.00 0.00 N
ATOM 149 C4 U A 7 36.441 5.830 39.705 1.00 0.00 C
ATOM 150 O4 U A 7 36.233 6.062 40.903 1.00 0.00 O
ATOM 151 C5 U A 7 37.621 5.192 39.299 1.00 0.00 C
ATOM 152 C6 U A 7 37.716 4.754 37.969 1.00 0.00 C
ATOM 153 P U A 8 37.555 4.171 31.327 1.00 0.00 P
ATOM 154 OP1 U A 8 36.381 4.530 30.514 1.00 0.00 O
ATOM 155 OP2 U A 8 38.033 2.778 31.309 1.00 0.00 O
ATOM 156 O5' U A 8 38.765 5.141 30.925 1.00 0.00 O
ATOM 157 C5' U A 8 38.506 6.496 30.557 1.00 0.00 C
ATOM 158 C4' U A 8 39.756 7.096 29.890 1.00 0.00 C
ATOM 159 O4' U A 8 40.921 6.762 30.627 1.00 0.00 O
ATOM 160 C3' U A 8 40.012 6.418 28.558 1.00 0.00 C
ATOM 161 O3' U A 8 39.103 6.793 27.527 1.00 0.00 O
ATOM 162 C2' U A 8 41.432 6.833 28.305 1.00 0.00 C
ATOM 163 O2' U A 8 41.469 8.186 27.991 1.00 0.00 O
ATOM 164 C1' U A 8 42.014 6.669 29.700 1.00 0.00 C
ATOM 165 N1 U A 8 42.516 5.302 29.862 1.00 0.00 N
ATOM 166 C2 U A 8 43.639 4.876 29.234 1.00 0.00 C
ATOM 167 O2 U A 8 44.374 5.675 28.646 1.00 0.00 O
ATOM 168 N3 U A 8 44.087 3.647 29.437 1.00 0.00 N
ATOM 169 C4 U A 8 43.467 2.812 30.258 1.00 0.00 C
ATOM 170 O4 U A 8 44.139 1.949 30.820 1.00 0.00 O
ATOM 171 C5 U A 8 42.301 3.227 30.892 1.00 0.00 C
ATOM 172 C6 U A 8 41.850 4.505 30.668 1.00 0.00 C
ATOM 173 P A A 9 38.558 5.617 26.671 1.00 0.00 P
ATOM 174 OP1 A A 9 37.182 5.414 26.889 1.00 0.00 O
ATOM 175 OP2 A A 9 39.447 4.547 26.815 1.00 0.00 O
ATOM 176 O5' A A 9 38.800 6.208 25.232 1.00 0.00 O
ATOM 177 C5' A A 9 38.070 7.314 24.745 1.00 0.00 C
ATOM 178 C4' A A 9 38.039 7.190 23.227 1.00 0.00 C
ATOM 179 O4' A A 9 39.378 7.115 22.750 1.00 0.00 O
ATOM 180 C3' A A 9 37.380 5.857 22.827 1.00 0.00 C
ATOM 181 O3' A A 9 36.632 6.096 21.655 1.00 0.00 O
ATOM 182 C2' A A 9 38.551 4.973 22.442 1.00 0.00 C
ATOM 183 O2' A A 9 38.152 4.125 21.394 1.00 0.00 O
ATOM 184 C1' A A 9 39.461 6.015 21.854 1.00 0.00 C
ATOM 185 N9 A A 9 40.814 5.457 21.830 1.00 0.00 N
ATOM 186 C8 A A 9 41.194 4.275 22.388 1.00 0.00 C
ATOM 187 N7 A A 9 42.541 4.093 22.149 1.00 0.00 N
ATOM 188 C5 A A 9 42.958 5.198 21.414 1.00 0.00 C
ATOM 189 C6 A A 9 44.193 5.553 20.877 1.00 0.00 C
ATOM 190 N6 A A 9 45.271 4.852 21.208 1.00 0.00 N
ATOM 191 N1 A A 9 44.309 6.688 20.177 1.00 0.00 N
ATOM 192 C2 A A 9 43.255 7.491 19.989 1.00 0.00 C
ATOM 193 N3 A A 9 42.066 7.197 20.494 1.00 0.00 N
ATOM 194 C4 A A 9 41.898 6.034 21.217 1.00 0.00 C
HETATM 195 P 2MG A 10 35.095 6.450 21.753 1.00 0.00 P
HETATM 196 OP1 2MG A 10 34.668 7.135 20.522 1.00 0.00 O
HETATM 197 OP2 2MG A 10 34.778 7.058 23.064 1.00 0.00 O
HETATM 198 O5' 2MG A 10 34.521 4.979 21.607 1.00 0.00 O
HETATM 199 C5' 2MG A 10 33.115 4.830 21.622 1.00 0.00 C
HETATM 200 C4' 2MG A 10 32.816 3.488 20.998 1.00 0.00 C
HETATM 201 O4' 2MG A 10 33.325 3.452 19.680 1.00 0.00 O
HETATM 202 C3' 2MG A 10 33.521 2.390 21.759 1.00 0.00 C
HETATM 203 O3' 2MG A 10 32.635 2.052 22.821 1.00 0.00 O
HETATM 204 C2' 2MG A 10 33.538 1.316 20.689 1.00 0.00 C
HETATM 205 O2' 2MG A 10 32.224 0.811 20.600 1.00 0.00 O
HETATM 206 C1' 2MG A 10 33.799 2.135 19.422 1.00 0.00 C
HETATM 207 N9 2MG A 10 35.239 2.318 19.178 1.00 0.00 N
HETATM 208 C8 2MG A 10 35.845 3.518 19.010 1.00 0.00 C
HETATM 209 N7 2MG A 10 37.186 3.308 18.791 1.00 0.00 N
HETATM 210 C5 2MG A 10 37.354 1.927 18.736 1.00 0.00 C
HETATM 211 C6 2MG A 10 38.473 1.125 18.520 1.00 0.00 C
HETATM 212 O6 2MG A 10 39.522 1.644 18.124 1.00 0.00 O
HETATM 213 N1 2MG A 10 38.340 -0.191 18.462 1.00 0.00 N
HETATM 214 C2 2MG A 10 37.154 -0.778 18.601 1.00 0.00 C
HETATM 215 N2 2MG A 10 37.107 -2.099 18.763 1.00 0.00 N
HETATM 216 CM2 2MG A 10 35.812 -2.765 18.885 1.00 0.00 C
HETATM 217 N3 2MG A 10 36.061 -0.051 18.830 1.00 0.00 N
HETATM 218 C4 2MG A 10 36.149 1.323 18.918 1.00 0.00 C
ATOM 219 P C A 11 33.284 1.751 24.235 1.00 0.00 P
ATOM 220 OP1 C A 11 32.252 1.897 25.278 1.00 0.00 O
ATOM 221 OP2 C A 11 34.556 2.501 24.359 1.00 0.00 O
ATOM 222 O5' C A 11 33.680 0.227 24.076 1.00 0.00 O
ATOM 223 C5' C A 11 32.731 -0.816 23.990 1.00 0.00 C
ATOM 224 C4' C A 11 33.585 -2.065 23.729 1.00 0.00 C
ATOM 225 O4' C A 11 34.364 -1.811 22.569 1.00 0.00 O
ATOM 226 C3' C A 11 34.625 -2.318 24.833 1.00 0.00 C
ATOM 227 O3' C A 11 34.085 -3.176 25.844 1.00 0.00 O
ATOM 228 C2' C A 11 35.624 -3.148 24.041 1.00 0.00 C
ATOM 229 O2' C A 11 35.097 -4.445 23.948 1.00 0.00 O
ATOM 230 C1' C A 11 35.570 -2.576 22.635 1.00 0.00 C
ATOM 231 N1 C A 11 36.688 -1.640 22.420 1.00 0.00 N
ATOM 232 C2 C A 11 37.924 -2.093 22.139 1.00 0.00 C
ATOM 233 O2 C A 11 38.153 -3.314 22.152 1.00 0.00 O
ATOM 234 N3 C A 11 38.944 -1.234 21.937 1.00 0.00 N
ATOM 235 C4 C A 11 38.736 0.082 21.994 1.00 0.00 C
ATOM 236 N4 C A 11 39.692 0.934 21.676 1.00 0.00 N
ATOM 237 C5 C A 11 37.464 0.561 22.239 1.00 0.00 C
ATOM 238 C6 C A 11 36.439 -0.347 22.433 1.00 0.00 C
ATOM 239 P U A 12 34.783 -3.267 27.298 1.00 0.00 P
ATOM 240 OP1 U A 12 34.001 -4.179 28.122 1.00 0.00 O
ATOM 241 OP2 U A 12 34.934 -1.888 27.776 1.00 0.00 O
ATOM 242 O5' U A 12 36.212 -3.940 27.034 1.00 0.00 O
ATOM 243 C5' U A 12 36.395 -5.332 27.273 1.00 0.00 C
ATOM 244 C4' U A 12 37.888 -5.609 27.068 1.00 0.00 C
ATOM 245 O4' U A 12 38.247 -4.914 25.885 1.00 0.00 O
ATOM 246 C3' U A 12 38.732 -4.877 28.107 1.00 0.00 C
ATOM 247 O3' U A 12 38.938 -5.638 29.283 1.00 0.00 O
ATOM 248 C2' U A 12 40.047 -4.884 27.363 1.00 0.00 C
ATOM 249 O2' U A 12 40.515 -6.205 27.345 1.00 0.00 O
ATOM 250 C1' U A 12 39.627 -4.594 25.946 1.00 0.00 C
ATOM 251 N1 U A 12 39.843 -3.171 25.604 1.00 0.00 N
ATOM 252 C2 U A 12 41.002 -2.817 25.048 1.00 0.00 C
ATOM 253 O2 U A 12 41.962 -3.600 25.151 1.00 0.00 O
ATOM 254 N3 U A 12 41.235 -1.547 24.683 1.00 0.00 N
ATOM 255 C4 U A 12 40.335 -0.603 24.898 1.00 0.00 C
ATOM 256 O4 U A 12 40.543 0.568 24.525 1.00 0.00 O
ATOM 257 C5 U A 12 39.141 -0.939 25.528 1.00 0.00 C
ATOM 258 C6 U A 12 38.923 -2.263 25.882 1.00 0.00 C
ATOM 259 P C A 13 39.176 -4.864 30.657 1.00 0.00 P
ATOM 260 OP1 C A 13 39.427 -5.838 31.740 1.00 0.00 O
ATOM 261 OP2 C A 13 38.024 -3.940 30.762 1.00 0.00 O
ATOM 262 O5' C A 13 40.498 -4.001 30.449 1.00 0.00 O
ATOM 263 C5' C A 13 41.734 -4.546 30.868 1.00 0.00 C
ATOM 264 C4' C A 13 42.875 -3.866 30.117 1.00 0.00 C
ATOM 265 O4' C A 13 42.391 -3.180 28.982 1.00 0.00 O
ATOM 266 C3' C A 13 43.615 -2.756 30.849 1.00 0.00 C
ATOM 267 O3' C A 13 44.491 -3.300 31.817 1.00 0.00 O
ATOM 268 C2' C A 13 44.472 -2.320 29.664 1.00 0.00 C
ATOM 269 O2' C A 13 45.453 -3.307 29.490 1.00 0.00 O
ATOM 270 C1' C A 13 43.504 -2.435 28.483 1.00 0.00 C
ATOM 271 N1 C A 13 43.017 -1.099 28.151 1.00 0.00 N
ATOM 272 C2 C A 13 43.798 -0.257 27.476 1.00 0.00 C
ATOM 273 O2 C A 13 44.959 -0.597 27.203 1.00 0.00 O
ATOM 274 N3 C A 13 43.373 0.964 27.144 1.00 0.00 N
ATOM 275 C4 C A 13 42.163 1.383 27.539 1.00 0.00 C
ATOM 276 N4 C A 13 41.621 2.503 27.033 1.00 0.00 N
ATOM 277 C5 C A 13 41.377 0.545 28.311 1.00 0.00 C
ATOM 278 C6 C A 13 41.847 -0.715 28.614 1.00 0.00 C
ATOM 279 P A A 14 45.320 -2.380 32.826 1.00 0.00 P
ATOM 280 OP1 A A 14 45.945 -3.316 33.790 1.00 0.00 O
ATOM 281 OP2 A A 14 44.464 -1.295 33.340 1.00 0.00 O
ATOM 282 O5' A A 14 46.448 -1.667 31.967 1.00 0.00 O
ATOM 283 C5' A A 14 47.595 -2.369 31.504 1.00 0.00 C
ATOM 284 C4' A A 14 48.555 -1.472 30.675 1.00 0.00 C
ATOM 285 O4' A A 14 47.954 -0.806 29.579 1.00 0.00 O
ATOM 286 C3' A A 14 49.181 -0.324 31.439 1.00 0.00 C
ATOM 287 O3' A A 14 50.133 -0.821 32.358 1.00 0.00 O
ATOM 288 C2' A A 14 49.893 0.340 30.274 1.00 0.00 C
ATOM 289 O2' A A 14 51.067 -0.352 29.926 1.00 0.00 O
ATOM 290 C1' A A 14 48.908 0.151 29.142 1.00 0.00 C
ATOM 291 N9 A A 14 48.240 1.414 28.953 1.00 0.00 N
ATOM 292 C8 A A 14 46.966 1.665 29.277 1.00 0.00 C
ATOM 293 N7 A A 14 46.679 2.954 28.906 1.00 0.00 N
ATOM 294 C5 A A 14 47.850 3.493 28.357 1.00 0.00 C
ATOM 295 C6 A A 14 48.151 4.740 27.798 1.00 0.00 C
ATOM 296 N6 A A 14 47.226 5.695 27.752 1.00 0.00 N
ATOM 297 N1 A A 14 49.360 4.965 27.312 1.00 0.00 N
ATOM 298 C2 A A 14 50.304 4.020 27.353 1.00 0.00 C
ATOM 299 N3 A A 14 50.063 2.824 27.891 1.00 0.00 N
ATOM 300 C4 A A 14 48.817 2.543 28.409 1.00 0.00 C
ATOM 301 P G A 15 50.299 -0.095 33.766 1.00 0.00 P
ATOM 302 OP1 G A 15 51.313 -0.857 34.527 1.00 0.00 O
ATOM 303 OP2 G A 15 48.941 0.101 34.347 1.00 0.00 O
ATOM 304 O5' G A 15 50.845 1.366 33.390 1.00 0.00 O
ATOM 305 C5' G A 15 52.162 1.593 32.937 1.00 0.00 C
ATOM 306 C4' G A 15 52.179 2.963 32.252 1.00 0.00 C
ATOM 307 O4' G A 15 51.108 3.049 31.324 1.00 0.00 O
ATOM 308 C3' G A 15 51.867 4.059 33.205 1.00 0.00 C
ATOM 309 O3' G A 15 52.975 4.415 33.989 1.00 0.00 O
ATOM 310 C2' G A 15 51.513 5.160 32.225 1.00 0.00 C
ATOM 311 O2' G A 15 52.662 5.692 31.646 1.00 0.00 O
ATOM 312 C1' G A 15 50.739 4.417 31.162 1.00 0.00 C
ATOM 313 N9 G A 15 49.312 4.566 31.523 1.00 0.00 N
ATOM 314 C8 G A 15 48.568 3.660 32.213 1.00 0.00 C
ATOM 315 N7 G A 15 47.309 4.162 32.382 1.00 0.00 N
ATOM 316 C5 G A 15 47.290 5.404 31.760 1.00 0.00 C
ATOM 317 C6 G A 15 46.293 6.359 31.607 1.00 0.00 C
ATOM 318 O6 G A 15 45.212 6.221 32.206 1.00 0.00 O
ATOM 319 N1 G A 15 46.546 7.474 30.904 1.00 0.00 N
ATOM 320 C2 G A 15 47.752 7.700 30.350 1.00 0.00 C
ATOM 321 N2 G A 15 47.843 8.608 29.402 1.00 0.00 N
ATOM 322 N3 G A 15 48.739 6.827 30.499 1.00 0.00 N
ATOM 323 C4 G A 15 48.517 5.650 31.207 1.00 0.00 C
HETATM 324 P H2U A 16 52.658 5.174 35.325 1.00 0.00 P
HETATM 325 OP1 H2U A 16 52.078 4.251 36.292 1.00 0.00 O
HETATM 326 OP2 H2U A 16 51.980 6.391 35.002 1.00 0.00 O
HETATM 327 O5' H2U A 16 54.065 5.545 35.771 1.00 0.00 O
HETATM 328 C5' H2U A 16 54.861 6.286 34.887 1.00 0.00 C
HETATM 329 C4' H2U A 16 55.699 7.273 35.679 1.00 0.00 C
HETATM 330 O4' H2U A 16 54.879 8.305 36.210 1.00 0.00 O
HETATM 331 C3' H2U A 16 56.362 6.591 36.874 1.00 0.00 C
HETATM 332 O3' H2U A 16 57.486 7.390 37.186 1.00 0.00 O
HETATM 333 C1' H2U A 16 54.660 8.078 37.604 1.00 0.00 C
HETATM 334 C2' H2U A 16 55.307 6.748 37.970 1.00 0.00 C
HETATM 335 O2' H2U A 16 55.865 6.809 39.269 1.00 0.00 O
HETATM 336 N1 H2U A 16 53.222 7.997 37.854 1.00 0.00 N
HETATM 337 C2 H2U A 16 52.571 9.114 38.058 1.00 0.00 C
HETATM 338 O2 H2U A 16 53.193 10.070 38.533 1.00 0.00 O
HETATM 339 N3 H2U A 16 51.255 9.093 38.204 1.00 0.00 N
HETATM 340 C4 H2U A 16 50.554 7.974 38.166 1.00 0.00 C
HETATM 341 O4 H2U A 16 49.321 8.020 38.095 1.00 0.00 O
HETATM 342 C5 H2U A 16 51.237 6.667 37.975 1.00 0.00 C
HETATM 343 C6 H2U A 16 52.678 6.774 38.429 1.00 0.00 C
HETATM 344 P H2U A 17 58.783 7.380 36.302 1.00 0.00 P
HETATM 345 OP1 H2U A 17 58.524 7.308 34.863 1.00 0.00 O
HETATM 346 OP2 H2U A 17 59.677 6.443 36.958 1.00 0.00 O
HETATM 347 O5' H2U A 17 59.225 8.856 36.605 1.00 0.00 O
HETATM 348 C5' H2U A 17 59.096 9.318 37.936 1.00 0.00 C
HETATM 349 C4' H2U A 17 59.075 10.841 37.981 1.00 0.00 C
HETATM 350 O4' H2U A 17 60.315 11.374 37.536 1.00 0.00 O
HETATM 351 C3' H2U A 17 58.006 11.343 37.039 1.00 0.00 C
HETATM 352 O3' H2U A 17 57.404 12.456 37.686 1.00 0.00 O
HETATM 353 C1' H2U A 17 60.124 12.192 36.389 1.00 0.00 C
HETATM 354 C2' H2U A 17 58.810 11.722 35.800 1.00 0.00 C
HETATM 355 O2' H2U A 17 58.176 12.781 35.127 1.00 0.00 O
HETATM 356 N1 H2U A 17 61.280 12.038 35.466 1.00 0.00 N
HETATM 357 C2 H2U A 17 62.322 12.870 35.539 1.00 0.00 C
HETATM 358 O2 H2U A 17 62.227 13.920 36.170 1.00 0.00 O
HETATM 359 N3 H2U A 17 63.395 12.682 34.780 1.00 0.00 N
HETATM 360 C4 H2U A 17 63.503 11.629 33.992 1.00 0.00 C
HETATM 361 O4 H2U A 17 64.559 11.423 33.387 1.00 0.00 O
HETATM 362 C5 H2U A 17 62.424 10.596 33.977 1.00 0.00 C
HETATM 363 C6 H2U A 17 61.109 11.294 34.250 1.00 0.00 C
ATOM 364 P G A 18 56.153 12.293 38.707 1.00 0.00 P
ATOM 365 OP1 G A 18 56.056 13.436 39.635 1.00 0.00 O
ATOM 366 OP2 G A 18 56.118 10.952 39.307 1.00 0.00 O
ATOM 367 O5' G A 18 54.999 12.483 37.624 1.00 0.00 O
ATOM 368 C5' G A 18 54.165 13.626 37.748 1.00 0.00 C
ATOM 369 C4' G A 18 53.964 14.366 36.416 1.00 0.00 C
ATOM 370 O4' G A 18 53.364 15.610 36.763 1.00 0.00 O
ATOM 371 C3' G A 18 55.328 14.792 35.868 1.00 0.00 C
ATOM 372 O3' G A 18 55.145 15.448 34.623 1.00 0.00 O
ATOM 373 C2' G A 18 55.767 15.871 36.845 1.00 0.00 C
ATOM 374 O2' G A 18 56.648 16.753 36.148 1.00 0.00 O
ATOM 375 C1' G A 18 54.414 16.537 37.011 1.00 0.00 C
ATOM 376 N9 G A 18 54.221 17.314 38.228 1.00 0.00 N
ATOM 377 C8 G A 18 54.921 17.231 39.395 1.00 0.00 C
ATOM 378 N7 G A 18 54.414 18.198 40.267 1.00 0.00 N
ATOM 379 C5 G A 18 53.419 18.878 39.558 1.00 0.00 C
ATOM 380 C6 G A 18 52.635 20.003 39.830 1.00 0.00 C
ATOM 381 O6 G A 18 52.927 20.748 40.770 1.00 0.00 O
ATOM 382 N1 G A 18 51.786 20.442 38.911 1.00 0.00 N
ATOM 383 C2 G A 18 51.674 19.862 37.721 1.00 0.00 C
ATOM 384 N2 G A 18 50.943 20.439 36.785 1.00 0.00 N
ATOM 385 N3 G A 18 52.408 18.816 37.407 1.00 0.00 N
ATOM 386 C4 G A 18 53.303 18.310 38.324 1.00 0.00 C
ATOM 387 P G A 19 55.690 14.740 33.288 1.00 0.00 P
ATOM 388 OP1 G A 19 54.860 13.575 32.978 1.00 0.00 O
ATOM 389 OP2 G A 19 57.139 14.523 33.442 1.00 0.00 O
ATOM 390 O5' G A 19 55.497 15.908 32.203 1.00 0.00 O
ATOM 391 C5' G A 19 54.260 16.030 31.526 1.00 0.00 C
ATOM 392 C4' G A 19 54.276 17.280 30.652 1.00 0.00 C
ATOM 393 O4' G A 19 54.936 18.283 31.412 1.00 0.00 O
ATOM 394 C3' G A 19 55.116 17.088 29.391 1.00 0.00 C
ATOM 395 O3' G A 19 54.489 17.842 28.392 1.00 0.00 O
ATOM 396 C2' G A 19 56.447 17.785 29.688 1.00 0.00 C
ATOM 397 O2' G A 19 56.888 18.463 28.534 1.00 0.00 O
ATOM 398 C1' G A 19 55.995 18.853 30.642 1.00 0.00 C
ATOM 399 N9 G A 19 57.010 19.154 31.603 1.00 0.00 N
ATOM 400 C8 G A 19 57.724 18.280 32.225 1.00 0.00 C
ATOM 401 N7 G A 19 58.383 18.918 33.213 1.00 0.00 N
ATOM 402 C5 G A 19 57.987 20.238 33.176 1.00 0.00 C
ATOM 403 C6 G A 19 58.241 21.328 33.968 1.00 0.00 C
ATOM 404 O6 G A 19 58.806 21.193 35.061 1.00 0.00 O
ATOM 405 N1 G A 19 57.689 22.437 33.693 1.00 0.00 N
ATOM 406 C2 G A 19 56.856 22.561 32.709 1.00 0.00 C
ATOM 407 N2 G A 19 56.308 23.725 32.463 1.00 0.00 N
ATOM 408 N3 G A 19 56.556 21.565 31.955 1.00 0.00 N
ATOM 409 C4 G A 19 57.153 20.369 32.176 1.00 0.00 C
ATOM 410 P G A 20 53.238 17.243 27.600 1.00 0.00 P
ATOM 411 OP1 G A 20 52.674 18.266 26.675 1.00 0.00 O
ATOM 412 OP2 G A 20 52.333 16.523 28.522 1.00 0.00 O
ATOM 413 O5' G A 20 53.964 16.230 26.644 1.00 0.00 O
ATOM 414 C5' G A 20 54.362 16.802 25.409 1.00 0.00 C
ATOM 415 C4' G A 20 54.456 15.707 24.338 1.00 0.00 C
ATOM 416 O4' G A 20 55.331 14.674 24.748 1.00 0.00 O
ATOM 417 C3' G A 20 53.106 15.085 24.140 1.00 0.00 C
ATOM 418 O3' G A 20 52.438 15.809 23.122 1.00 0.00 O
ATOM 419 C2' G A 20 53.523 13.769 23.571 1.00 0.00 C
ATOM 420 O2' G A 20 53.886 13.988 22.243 1.00 0.00 O
ATOM 421 C1' G A 20 54.777 13.434 24.350 1.00 0.00 C
ATOM 422 N9 G A 20 54.370 12.657 25.536 1.00 0.00 N
ATOM 423 C8 G A 20 54.586 13.022 26.814 1.00 0.00 C
ATOM 424 N7 G A 20 53.997 12.106 27.630 1.00 0.00 N
ATOM 425 C5 G A 20 53.426 11.150 26.812 1.00 0.00 C
ATOM 426 C6 G A 20 52.742 9.971 27.099 1.00 0.00 C
ATOM 427 O6 G A 20 52.774 9.546 28.254 1.00 0.00 O
ATOM 428 N1 G A 20 52.289 9.192 26.113 1.00 0.00 N
ATOM 429 C2 G A 20 52.515 9.504 24.839 1.00 0.00 C
ATOM 430 N2 G A 20 52.145 8.655 23.897 1.00 0.00 N
ATOM 431 N3 G A 20 53.216 10.611 24.513 1.00 0.00 N
ATOM 432 C4 G A 20 53.693 11.455 25.518 1.00 0.00 C
ATOM 433 P A A 21 50.876 16.180 23.223 1.00 0.00 P
ATOM 434 OP1 A A 21 50.526 16.924 21.985 1.00 0.00 O
ATOM 435 OP2 A A 21 50.552 16.819 24.515 1.00 0.00 O
ATOM 436 O5' A A 21 50.099 14.800 23.226 1.00 0.00 O
ATOM 437 C5' A A 21 49.678 14.188 24.436 1.00 0.00 C
ATOM 438 C4' A A 21 49.738 12.673 24.233 1.00 0.00 C
ATOM 439 O4' A A 21 48.811 12.110 25.164 1.00 0.00 O
ATOM 440 C3' A A 21 49.240 12.344 22.824 1.00 0.00 C
ATOM 441 O3' A A 21 49.644 11.025 22.477 1.00 0.00 O
ATOM 442 C2' A A 21 47.752 12.300 23.088 1.00 0.00 C
ATOM 443 O2' A A 21 47.116 11.494 22.122 1.00 0.00 O
ATOM 444 C1' A A 21 47.724 11.590 24.428 1.00 0.00 C
ATOM 445 N9 A A 21 46.412 11.764 25.069 1.00 0.00 N
ATOM 446 C8 A A 21 45.578 12.816 24.875 1.00 0.00 C
ATOM 447 N7 A A 21 44.369 12.526 25.464 1.00 0.00 N
ATOM 448 C5 A A 21 44.493 11.266 26.036 1.00 0.00 C
ATOM 449 C6 A A 21 43.582 10.433 26.693 1.00 0.00 C
ATOM 450 N6 A A 21 42.274 10.631 26.525 1.00 0.00 N
ATOM 451 N1 A A 21 43.986 9.258 27.149 1.00 0.00 N
ATOM 452 C2 A A 21 45.236 8.839 26.954 1.00 0.00 C
ATOM 453 N3 A A 21 46.132 9.582 26.310 1.00 0.00 N
ATOM 454 C4 A A 21 45.775 10.830 25.850 1.00 0.00 C
ATOM 455 P G A 22 49.849 10.558 20.991 1.00 0.00 P
ATOM 456 OP1 G A 22 51.220 10.581 20.659 1.00 0.00 O
ATOM 457 OP2 G A 22 48.955 11.289 20.170 1.00 0.00 O
ATOM 458 O5' G A 22 49.368 9.073 21.024 1.00 0.00 O
ATOM 459 C5' G A 22 50.445 8.167 21.115 1.00 0.00 C
ATOM 460 C4' G A 22 50.148 6.938 21.962 1.00 0.00 C
ATOM 461 O4' G A 22 49.462 7.201 23.178 1.00 0.00 O
ATOM 462 C3' G A 22 49.382 5.826 21.265 1.00 0.00 C
ATOM 463 O3' G A 22 50.210 5.206 20.258 1.00 0.00 O
ATOM 464 C2' G A 22 49.184 4.922 22.491 1.00 0.00 C
ATOM 465 O2' G A 22 50.364 4.200 22.712 1.00 0.00 O
ATOM 466 C1' G A 22 49.013 5.908 23.666 1.00 0.00 C
ATOM 467 N9 G A 22 47.577 5.935 23.998 1.00 0.00 N
ATOM 468 C8 G A 22 46.733 6.964 23.739 1.00 0.00 C
ATOM 469 N7 G A 22 45.469 6.611 24.161 1.00 0.00 N
ATOM 470 C5 G A 22 45.551 5.316 24.656 1.00 0.00 C
ATOM 471 C6 G A 22 44.619 4.466 25.241 1.00 0.00 C
ATOM 472 O6 G A 22 43.438 4.813 25.350 1.00 0.00 O
ATOM 473 N1 G A 22 44.967 3.240 25.587 1.00 0.00 N
ATOM 474 C2 G A 22 46.219 2.809 25.422 1.00 0.00 C
ATOM 475 N2 G A 22 46.580 1.647 25.959 1.00 0.00 N
ATOM 476 N3 G A 22 47.153 3.602 24.912 1.00 0.00 N
ATOM 477 C4 G A 22 46.840 4.885 24.525 1.00 0.00 C
ATOM 478 P A A 23 49.603 4.196 19.130 1.00 0.00 P
ATOM 479 OP1 A A 23 50.587 4.057 18.140 1.00 0.00 O
ATOM 480 OP2 A A 23 48.222 4.622 18.730 1.00 0.00 O
ATOM 481 O5' A A 23 49.537 2.763 19.863 1.00 0.00 O
ATOM 482 C5' A A 23 50.682 1.950 20.025 1.00 0.00 C
ATOM 483 C4' A A 23 50.293 0.612 20.711 1.00 0.00 C
ATOM 484 O4' A A 23 49.696 0.807 21.995 1.00 0.00 O
ATOM 485 C3' A A 23 49.302 -0.213 19.912 1.00 0.00 C
ATOM 486 O3' A A 23 50.026 -0.901 18.895 1.00 0.00 O
ATOM 487 C2' A A 23 48.865 -1.159 21.021 1.00 0.00 C
ATOM 488 O2' A A 23 49.895 -2.048 21.325 1.00 0.00 O
ATOM 489 C1' A A 23 48.760 -0.243 22.222 1.00 0.00 C
ATOM 490 N9 A A 23 47.450 0.399 22.274 1.00 0.00 N
ATOM 491 C8 A A 23 47.196 1.658 21.873 1.00 0.00 C
ATOM 492 N7 A A 23 45.903 1.991 22.198 1.00 0.00 N
ATOM 493 C5 A A 23 45.370 0.878 22.839 1.00 0.00 C
ATOM 494 C6 A A 23 44.087 0.603 23.320 1.00 0.00 C
ATOM 495 N6 A A 23 43.073 1.419 23.024 1.00 0.00 N
ATOM 496 N1 A A 23 43.858 -0.565 23.894 1.00 0.00 N
ATOM 497 C2 A A 23 44.825 -1.494 24.008 1.00 0.00 C
ATOM 498 N3 A A 23 46.033 -1.305 23.530 1.00 0.00 N
ATOM 499 C4 A A 23 46.327 -0.113 22.893 1.00 0.00 C
ATOM 500 P G A 24 49.368 -1.348 17.492 1.00 0.00 P
ATOM 501 OP1 G A 24 50.492 -1.683 16.586 1.00 0.00 O
ATOM 502 OP2 G A 24 48.340 -0.373 17.007 1.00 0.00 O
ATOM 503 O5' G A 24 48.588 -2.649 17.928 1.00 0.00 O
ATOM 504 C5' G A 24 49.246 -3.821 18.384 1.00 0.00 C
ATOM 505 C4' G A 24 48.107 -4.664 18.973 1.00 0.00 C
ATOM 506 O4' G A 24 47.563 -3.949 20.059 1.00 0.00 O
ATOM 507 C3' G A 24 46.927 -4.760 18.007 1.00 0.00 C
ATOM 508 O3' G A 24 47.119 -5.843 17.131 1.00 0.00 O
ATOM 509 C2' G A 24 45.807 -5.121 18.964 1.00 0.00 C
ATOM 510 O2' G A 24 45.742 -6.536 19.192 1.00 0.00 O
ATOM 511 C1' G A 24 46.220 -4.370 20.237 1.00 0.00 C
ATOM 512 N9 G A 24 45.440 -3.145 20.252 1.00 0.00 N
ATOM 513 C8 G A 24 45.782 -1.986 19.649 1.00 0.00 C
ATOM 514 N7 G A 24 44.734 -1.109 19.782 1.00 0.00 N
ATOM 515 C5 G A 24 43.741 -1.778 20.482 1.00 0.00 C
ATOM 516 C6 G A 24 42.431 -1.443 20.790 1.00 0.00 C
ATOM 517 O6 G A 24 42.015 -0.301 20.546 1.00 0.00 O
ATOM 518 N1 G A 24 41.667 -2.313 21.447 1.00 0.00 N
ATOM 519 C2 G A 24 42.136 -3.517 21.825 1.00 0.00 C
ATOM 520 N2 G A 24 41.266 -4.454 22.188 1.00 0.00 N
ATOM 521 N3 G A 24 43.387 -3.873 21.545 1.00 0.00 N
ATOM 522 C4 G A 24 44.206 -3.006 20.842 1.00 0.00 C
ATOM 523 P C A 25 46.480 -5.780 15.681 1.00 0.00 P
ATOM 524 OP1 C A 25 46.946 -7.006 15.012 1.00 0.00 O
ATOM 525 OP2 C A 25 46.740 -4.455 15.106 1.00 0.00 O
ATOM 526 O5' C A 25 44.917 -5.867 15.872 1.00 0.00 O
ATOM 527 C5' C A 25 44.337 -7.144 16.033 1.00 0.00 C
ATOM 528 C4' C A 25 42.891 -6.952 16.492 1.00 0.00 C
ATOM 529 O4' C A 25 42.873 -6.029 17.574 1.00 0.00 O
ATOM 530 C3' C A 25 42.016 -6.311 15.420 1.00 0.00 C
ATOM 531 O3' C A 25 41.440 -7.297 14.578 1.00 0.00 O
ATOM 532 C2' C A 25 40.900 -5.794 16.298 1.00 0.00 C
ATOM 533 O2' C A 25 39.865 -6.739 16.393 1.00 0.00 O
ATOM 534 C1' C A 25 41.539 -5.551 17.667 1.00 0.00 C
ATOM 535 N1 C A 25 41.639 -4.124 17.725 1.00 0.00 N
ATOM 536 C2 C A 25 40.638 -3.430 18.204 1.00 0.00 C
ATOM 537 O2 C A 25 39.532 -3.987 18.315 1.00 0.00 O
ATOM 538 N3 C A 25 40.693 -2.102 18.204 1.00 0.00 N
ATOM 539 C4 C A 25 41.714 -1.455 17.666 1.00 0.00 C
ATOM 540 N4 C A 25 41.840 -0.145 17.831 1.00 0.00 N
ATOM 541 C5 C A 25 42.749 -2.175 17.113 1.00 0.00 C
ATOM 542 C6 C A 25 42.675 -3.545 17.153 1.00 0.00 C
HETATM 543 P M2G A 26 40.942 -6.906 13.106 1.00 0.00 P
HETATM 544 OP1 M2G A 26 40.308 -8.115 12.530 1.00 0.00 O
HETATM 545 OP2 M2G A 26 42.084 -6.275 12.407 1.00 0.00 O
HETATM 546 O5' M2G A 26 39.822 -5.804 13.322 1.00 0.00 O
HETATM 547 C5' M2G A 26 38.522 -6.196 13.739 1.00 0.00 C
HETATM 548 C4' M2G A 26 37.776 -4.931 14.147 1.00 0.00 C
HETATM 549 O4' M2G A 26 38.698 -4.077 14.815 1.00 0.00 O
HETATM 550 C3' M2G A 26 37.429 -4.102 12.925 1.00 0.00 C
HETATM 551 O3' M2G A 26 36.257 -4.572 12.288 1.00 0.00 O
HETATM 552 C2' M2G A 26 37.202 -2.728 13.545 1.00 0.00 C
HETATM 553 O2' M2G A 26 35.878 -2.579 14.024 1.00 0.00 O
HETATM 554 C1' M2G A 26 38.144 -2.767 14.736 1.00 0.00 C
HETATM 555 N9 M2G A 26 39.210 -1.823 14.516 1.00 0.00 N
HETATM 556 C8 M2G A 26 40.454 -2.128 14.144 1.00 0.00 C
HETATM 557 N7 M2G A 26 41.194 -0.964 14.128 1.00 0.00 N
HETATM 558 C5 M2G A 26 40.333 0.073 14.472 1.00 0.00 C
HETATM 559 C6 M2G A 26 40.524 1.449 14.680 1.00 0.00 C
HETATM 560 O6 M2G A 26 41.674 1.915 14.761 1.00 0.00 O
HETATM 561 N1 M2G A 26 39.476 2.220 14.985 1.00 0.00 N
HETATM 562 C2 M2G A 26 38.248 1.708 15.120 1.00 0.00 C
HETATM 563 N2 M2G A 26 37.227 2.524 15.257 1.00 0.00 N
HETATM 564 N3 M2G A 26 38.021 0.385 14.963 1.00 0.00 N
HETATM 565 C4 M2G A 26 39.082 -0.455 14.637 1.00 0.00 C
HETATM 566 CM1 M2G A 26 37.418 3.967 15.049 1.00 0.00 C
HETATM 567 CM2 M2G A 26 35.871 1.968 15.388 1.00 0.00 C
ATOM 568 P C A 27 36.262 -4.476 10.703 1.00 0.00 P
ATOM 569 OP1 C A 27 35.020 -5.061 10.165 1.00 0.00 O
ATOM 570 OP2 C A 27 37.573 -4.980 10.273 1.00 0.00 O
ATOM 571 O5' C A 27 36.167 -2.925 10.487 1.00 0.00 O
ATOM 572 C5' C A 27 34.868 -2.378 10.577 1.00 0.00 C
ATOM 573 C4' C A 27 34.953 -0.848 10.506 1.00 0.00 C
ATOM 574 O4' C A 27 35.801 -0.340 11.528 1.00 0.00 O
ATOM 575 C3' C A 27 35.574 -0.345 9.220 1.00 0.00 C
ATOM 576 O3' C A 27 34.653 -0.378 8.146 1.00 0.00 O
ATOM 577 C2' C A 27 35.862 1.091 9.626 1.00 0.00 C
ATOM 578 O2' C A 27 34.714 1.909 9.481 1.00 0.00 O
ATOM 579 C1' C A 27 36.255 0.957 11.110 1.00 0.00 C
ATOM 580 N1 C A 27 37.722 0.919 11.160 1.00 0.00 N
ATOM 581 C2 C A 27 38.416 2.054 11.102 1.00 0.00 C
ATOM 582 O2 C A 27 37.843 3.093 10.735 1.00 0.00 O
ATOM 583 N3 C A 27 39.751 2.034 11.111 1.00 0.00 N
ATOM 584 C4 C A 27 40.429 0.890 11.133 1.00 0.00 C
ATOM 585 N4 C A 27 41.710 0.889 11.493 1.00 0.00 N
ATOM 586 C5 C A 27 39.732 -0.298 11.125 1.00 0.00 C
ATOM 587 C6 C A 27 38.346 -0.250 11.122 1.00 0.00 C
ATOM 588 P C A 28 35.253 -0.591 6.671 1.00 0.00 P
ATOM 589 OP1 C A 28 34.149 -0.776 5.721 1.00 0.00 O
ATOM 590 OP2 C A 28 36.298 -1.634 6.798 1.00 0.00 O
ATOM 591 O5' C A 28 36.008 0.772 6.328 1.00 0.00 O
ATOM 592 C5' C A 28 35.330 1.951 5.949 1.00 0.00 C
ATOM 593 C4' C A 28 36.418 2.966 5.573 1.00 0.00 C
ATOM 594 O4' C A 28 37.318 3.148 6.661 1.00 0.00 O
ATOM 595 C3' C A 28 37.281 2.434 4.437 1.00 0.00 C
ATOM 596 O3' C A 28 36.668 2.649 3.160 1.00 0.00 O
ATOM 597 C2' C A 28 38.479 3.336 4.590 1.00 0.00 C
ATOM 598 O2' C A 28 38.177 4.586 3.978 1.00 0.00 O
ATOM 599 C1' C A 28 38.602 3.460 6.120 1.00 0.00 C
ATOM 600 N1 C A 28 39.571 2.482 6.676 1.00 0.00 N
ATOM 601 C2 C A 28 40.825 2.834 6.796 1.00 0.00 C
ATOM 602 O2 C A 28 41.220 3.765 6.088 1.00 0.00 O
ATOM 603 N3 C A 28 41.727 1.995 7.316 1.00 0.00 N
ATOM 604 C4 C A 28 41.395 0.778 7.711 1.00 0.00 C
ATOM 605 N4 C A 28 42.340 -0.123 7.954 1.00 0.00 N
ATOM 606 C5 C A 28 40.087 0.383 7.601 1.00 0.00 C
ATOM 607 C6 C A 28 39.173 1.292 7.086 1.00 0.00 C
ATOM 608 P A A 29 37.039 1.595 1.972 1.00 0.00 P
ATOM 609 OP1 A A 29 36.101 1.794 0.854 1.00 0.00 O
ATOM 610 OP2 A A 29 37.136 0.242 2.592 1.00 0.00 O
ATOM 611 O5' A A 29 38.491 2.102 1.528 1.00 0.00 O
ATOM 612 C5' A A 29 38.593 3.220 0.654 1.00 0.00 C
ATOM 613 C4' A A 29 40.021 3.752 0.692 1.00 0.00 C
ATOM 614 O4' A A 29 40.409 3.899 2.047 1.00 0.00 O
ATOM 615 C3' A A 29 41.050 2.794 0.132 1.00 0.00 C
ATOM 616 O3' A A 29 41.133 2.950 -1.275 1.00 0.00 O
ATOM 617 C2' A A 29 42.287 3.441 0.749 1.00 0.00 C
ATOM 618 O2' A A 29 42.536 4.671 0.110 1.00 0.00 O
ATOM 619 C1' A A 29 41.828 3.766 2.146 1.00 0.00 C
ATOM 620 N9 A A 29 42.124 2.615 2.995 1.00 0.00 N
ATOM 621 C8 A A 29 41.235 1.681 3.402 1.00 0.00 C
ATOM 622 N7 A A 29 41.883 0.806 4.230 1.00 0.00 N
ATOM 623 C5 A A 29 43.214 1.185 4.244 1.00 0.00 C
ATOM 624 C6 A A 29 44.324 0.662 4.885 1.00 0.00 C
ATOM 625 N6 A A 29 44.279 -0.558 5.356 1.00 0.00 N
ATOM 626 N1 A A 29 45.506 1.189 4.636 1.00 0.00 N
ATOM 627 C2 A A 29 45.665 2.223 3.791 1.00 0.00 C
ATOM 628 N3 A A 29 44.628 2.767 3.193 1.00 0.00 N
ATOM 629 C4 A A 29 43.375 2.245 3.415 1.00 0.00 C
ATOM 630 P G A 30 42.046 1.952 -2.141 1.00 0.00 P
ATOM 631 OP1 G A 30 41.832 2.266 -3.575 1.00 0.00 O
ATOM 632 OP2 G A 30 41.720 0.574 -1.683 1.00 0.00 O
ATOM 633 O5' G A 30 43.576 2.294 -1.737 1.00 0.00 O
ATOM 634 C5' G A 30 44.314 3.392 -2.271 1.00 0.00 C
ATOM 635 C4' G A 30 45.750 3.297 -1.712 1.00 0.00 C
ATOM 636 O4' G A 30 45.680 2.920 -0.335 1.00 0.00 O
ATOM 637 C3' G A 30 46.550 2.164 -2.355 1.00 0.00 C
ATOM 638 O3' G A 30 47.194 2.595 -3.547 1.00 0.00 O
ATOM 639 C2' G A 30 47.595 1.877 -1.276 1.00 0.00 C
ATOM 640 O2' G A 30 48.704 2.759 -1.364 1.00 0.00 O
ATOM 641 C1' G A 30 46.846 2.165 0.014 1.00 0.00 C
ATOM 642 N9 G A 30 46.397 0.897 0.594 1.00 0.00 N
ATOM 643 C8 G A 30 45.132 0.405 0.527 1.00 0.00 C
ATOM 644 N7 G A 30 45.075 -0.750 1.266 1.00 0.00 N
ATOM 645 C5 G A 30 46.354 -0.963 1.769 1.00 0.00 C
ATOM 646 C6 G A 30 46.860 -1.886 2.683 1.00 0.00 C
ATOM 647 O6 G A 30 46.146 -2.827 3.048 1.00 0.00 O
ATOM 648 N1 G A 30 48.162 -1.860 3.005 1.00 0.00 N
ATOM 649 C2 G A 30 48.991 -0.944 2.475 1.00 0.00 C
ATOM 650 N2 G A 30 50.296 -1.112 2.605 1.00 0.00 N
ATOM 651 N3 G A 30 48.536 -0.005 1.640 1.00 0.00 N
ATOM 652 C4 G A 30 47.192 0.009 1.288 1.00 0.00 C
ATOM 653 P A A 31 47.250 1.565 -4.785 1.00 0.00 P
ATOM 654 OP1 A A 31 47.915 2.226 -5.928 1.00 0.00 O
ATOM 655 OP2 A A 31 45.880 1.037 -4.998 1.00 0.00 O
ATOM 656 O5' A A 31 48.162 0.378 -4.203 1.00 0.00 O
ATOM 657 C5' A A 31 49.550 0.597 -4.024 1.00 0.00 C
ATOM 658 C4' A A 31 50.081 -0.545 -3.169 1.00 0.00 C
ATOM 659 O4' A A 31 49.186 -0.799 -2.096 1.00 0.00 O
ATOM 660 C3' A A 31 50.034 -1.876 -3.896 1.00 0.00 C
ATOM 661 O3' A A 31 51.103 -1.986 -4.824 1.00 0.00 O
ATOM 662 C2' A A 31 50.260 -2.800 -2.698 1.00 0.00 C
ATOM 663 O2' A A 31 51.645 -2.919 -2.448 1.00 0.00 O
ATOM 664 C1' A A 31 49.617 -2.037 -1.532 1.00 0.00 C
ATOM 665 N9 A A 31 48.437 -2.747 -1.007 1.00 0.00 N
ATOM 666 C8 A A 31 47.138 -2.427 -1.296 1.00 0.00 C
ATOM 667 N7 A A 31 46.318 -3.303 -0.618 1.00 0.00 N
ATOM 668 C5 A A 31 47.154 -4.192 0.061 1.00 0.00 C
ATOM 669 C6 A A 31 46.883 -5.284 0.898 1.00 0.00 C
ATOM 670 N6 A A 31 45.609 -5.654 1.112 1.00 0.00 N
ATOM 671 N1 A A 31 47.905 -6.001 1.429 1.00 0.00 N
ATOM 672 C2 A A 31 49.191 -5.674 1.162 1.00 0.00 C
ATOM 673 N3 A A 31 49.487 -4.621 0.365 1.00 0.00 N
ATOM 674 C4 A A 31 48.463 -3.863 -0.195 1.00 0.00 C
HETATM 675 N1 OMC A 32 47.626 -6.177 -3.315 1.00 0.00 N
HETATM 676 C2 OMC A 32 46.616 -6.752 -2.648 1.00 0.00 C
HETATM 677 N3 OMC A 32 45.390 -6.196 -2.630 1.00 0.00 N
HETATM 678 C4 OMC A 32 45.162 -5.035 -3.240 1.00 0.00 C
HETATM 679 C5 OMC A 32 46.205 -4.381 -3.886 1.00 0.00 C
HETATM 680 C6 OMC A 32 47.464 -4.983 -3.890 1.00 0.00 C
HETATM 681 O2 OMC A 32 46.848 -7.742 -1.940 1.00 0.00 O
HETATM 682 N4 OMC A 32 43.940 -4.520 -3.270 1.00 0.00 N
HETATM 683 C1' OMC A 32 48.963 -6.794 -3.293 1.00 0.00 C
HETATM 684 C2' OMC A 32 49.186 -7.826 -4.401 1.00 0.00 C
HETATM 685 O2' OMC A 32 50.015 -8.834 -3.845 1.00 0.00 O
HETATM 686 CM2 OMC A 32 49.278 -9.542 -2.867 1.00 0.00 C
HETATM 687 C3' OMC A 32 50.061 -7.075 -5.408 1.00 0.00 C
HETATM 688 C4' OMC A 32 50.895 -6.282 -4.422 1.00 0.00 C
HETATM 689 O4' OMC A 32 49.902 -5.757 -3.553 1.00 0.00 O
HETATM 690 O3' OMC A 32 50.923 -7.984 -6.081 1.00 0.00 O
HETATM 691 C5' OMC A 32 51.618 -5.127 -5.101 1.00 0.00 C
HETATM 692 O5' OMC A 32 50.583 -4.298 -5.594 1.00 0.00 O
HETATM 693 P OMC A 32 50.880 -2.845 -6.159 1.00 0.00 P
HETATM 694 OP1 OMC A 32 52.169 -2.861 -6.876 1.00 0.00 O
HETATM 695 OP2 OMC A 32 49.633 -2.392 -6.859 1.00 0.00 O
ATOM 696 P U A 33 50.521 -8.509 -7.546 1.00 0.00 P
ATOM 697 OP1 U A 33 51.631 -9.333 -8.090 1.00 0.00 O
ATOM 698 OP2 U A 33 50.028 -7.349 -8.326 1.00 0.00 O
ATOM 699 O5' U A 33 49.273 -9.455 -7.258 1.00 0.00 O
ATOM 700 C5' U A 33 49.491 -10.744 -6.714 1.00 0.00 C
ATOM 701 C4' U A 33 48.112 -11.327 -6.476 1.00 0.00 C
ATOM 702 O4' U A 33 47.436 -10.547 -5.490 1.00 0.00 O
ATOM 703 C3' U A 33 47.259 -11.151 -7.718 1.00 0.00 C
ATOM 704 O3' U A 33 47.537 -12.162 -8.662 1.00 0.00 O
ATOM 705 C2' U A 33 45.933 -11.452 -7.067 1.00 0.00 C
ATOM 706 O2' U A 33 45.961 -12.831 -6.768 1.00 0.00 O
ATOM 707 C1' U A 33 46.038 -10.693 -5.738 1.00 0.00 C
ATOM 708 N1 U A 33 45.447 -9.352 -5.891 1.00 0.00 N
ATOM 709 C2 U A 33 44.129 -9.175 -5.678 1.00 0.00 C
ATOM 710 O2 U A 33 43.497 -10.046 -5.069 1.00 0.00 O
ATOM 711 N3 U A 33 43.568 -7.978 -5.825 1.00 0.00 N
ATOM 712 C4 U A 33 44.300 -6.910 -6.146 1.00 0.00 C
ATOM 713 O4 U A 33 43.744 -5.886 -6.572 1.00 0.00 O
ATOM 714 C5 U A 33 45.677 -7.049 -6.296 1.00 0.00 C
ATOM 715 C6 U A 33 46.236 -8.313 -6.136 1.00 0.00 C
HETATM 716 P OMG A 34 47.219 -11.900 -10.223 1.00 0.00 P
HETATM 717 OP1 OMG A 34 47.589 -13.154 -10.940 1.00 0.00 O
HETATM 718 OP2 OMG A 34 47.895 -10.626 -10.599 1.00 0.00 O
HETATM 719 O5' OMG A 34 45.627 -11.690 -10.292 1.00 0.00 O
HETATM 720 C5' OMG A 34 45.110 -10.931 -11.373 1.00 0.00 C
HETATM 721 C4' OMG A 34 43.712 -11.427 -11.663 1.00 0.00 C
HETATM 722 O4' OMG A 34 43.790 -12.823 -11.892 1.00 0.00 O
HETATM 723 C3' OMG A 34 42.758 -11.230 -10.493 1.00 0.00 C
HETATM 724 O3' OMG A 34 42.083 -9.992 -10.665 1.00 0.00 O
HETATM 725 C2' OMG A 34 41.745 -12.317 -10.759 1.00 0.00 C
HETATM 726 O2' OMG A 34 40.723 -11.837 -11.621 1.00 0.00 O
HETATM 727 CM2 OMG A 34 39.703 -12.827 -11.720 1.00 0.00 C
HETATM 728 C1' OMG A 34 42.572 -13.404 -11.450 1.00 0.00 C
HETATM 729 N9 OMG A 34 42.900 -14.434 -10.458 1.00 0.00 N
HETATM 730 C8 OMG A 34 44.140 -14.897 -10.145 1.00 0.00 C
HETATM 731 N7 OMG A 34 43.997 -15.922 -9.230 1.00 0.00 N
HETATM 732 C5 OMG A 34 42.626 -16.051 -9.001 1.00 0.00 C
HETATM 733 C6 OMG A 34 41.861 -17.004 -8.326 1.00 0.00 C
HETATM 734 O6 OMG A 34 42.417 -17.943 -7.740 1.00 0.00 O
HETATM 735 N1 OMG A 34 40.531 -16.873 -8.277 1.00 0.00 N
HETATM 736 C2 OMG A 34 39.901 -15.860 -8.905 1.00 0.00 C
HETATM 737 N2 OMG A 34 38.613 -15.630 -8.665 1.00 0.00 N
HETATM 738 N3 OMG A 34 40.590 -14.975 -9.612 1.00 0.00 N
HETATM 739 C4 OMG A 34 41.968 -15.076 -9.690 1.00 0.00 C
ATOM 740 P A A 35 42.263 -8.835 -9.558 1.00 0.00 P
ATOM 741 OP1 A A 35 41.691 -7.570 -10.110 1.00 0.00 O
ATOM 742 OP2 A A 35 43.662 -8.886 -9.070 1.00 0.00 O
ATOM 743 O5' A A 35 41.303 -9.363 -8.403 1.00 0.00 O
ATOM 744 C5' A A 35 39.903 -9.320 -8.611 1.00 0.00 C
ATOM 745 C4' A A 35 39.250 -10.417 -7.768 1.00 0.00 C
ATOM 746 O4' A A 35 39.661 -11.735 -8.146 1.00 0.00 O
ATOM 747 C3' A A 35 39.523 -10.303 -6.279 1.00 0.00 C
ATOM 748 O3' A A 35 38.715 -9.247 -5.755 1.00 0.00 O
ATOM 749 C2' A A 35 38.947 -11.671 -5.930 1.00 0.00 C
ATOM 750 O2' A A 35 37.545 -11.601 -6.168 1.00 0.00 O
ATOM 751 C1' A A 35 39.525 -12.591 -7.006 1.00 0.00 C
ATOM 752 N9 A A 35 40.901 -13.006 -6.687 1.00 0.00 N
ATOM 753 C8 A A 35 42.019 -12.363 -7.122 1.00 0.00 C
ATOM 754 N7 A A 35 43.114 -13.037 -6.688 1.00 0.00 N
ATOM 755 C5 A A 35 42.653 -14.167 -6.029 1.00 0.00 C
ATOM 756 C6 A A 35 43.323 -15.269 -5.497 1.00 0.00 C
ATOM 757 N6 A A 35 44.647 -15.344 -5.598 1.00 0.00 N
ATOM 758 N1 A A 35 42.625 -16.274 -4.961 1.00 0.00 N
ATOM 759 C2 A A 35 41.279 -16.251 -4.943 1.00 0.00 C
ATOM 760 N3 A A 35 40.593 -15.217 -5.459 1.00 0.00 N
ATOM 761 C4 A A 35 41.281 -14.154 -6.024 1.00 0.00 C
ATOM 762 P A A 36 39.332 -8.094 -4.798 1.00 0.00 P
ATOM 763 OP1 A A 36 38.383 -6.952 -4.877 1.00 0.00 O
ATOM 764 OP2 A A 36 40.753 -7.859 -5.144 1.00 0.00 O
ATOM 765 O5' A A 36 39.227 -8.736 -3.318 1.00 0.00 O
ATOM 766 C5' A A 36 37.925 -8.819 -2.735 1.00 0.00 C
ATOM 767 C4' A A 36 37.621 -10.237 -2.237 1.00 0.00 C
ATOM 768 O4' A A 36 38.104 -11.210 -3.149 1.00 0.00 O
ATOM 769 C3' A A 36 38.308 -10.517 -0.919 1.00 0.00 C
ATOM 770 O3' A A 36 37.452 -10.013 0.095 1.00 0.00 O
ATOM 771 C2' A A 36 38.372 -12.055 -0.944 1.00 0.00 C
ATOM 772 O2' A A 36 37.170 -12.674 -0.514 1.00 0.00 O
ATOM 773 C1' A A 36 38.585 -12.352 -2.430 1.00 0.00 C
ATOM 774 N9 A A 36 40.025 -12.348 -2.637 1.00 0.00 N
ATOM 775 C8 A A 36 40.738 -11.293 -3.072 1.00 0.00 C
ATOM 776 N7 A A 36 42.061 -11.645 -3.113 1.00 0.00 N
ATOM 777 C5 A A 36 42.137 -12.948 -2.637 1.00 0.00 C
ATOM 778 C6 A A 36 43.207 -13.820 -2.457 1.00 0.00 C
ATOM 779 N6 A A 36 44.437 -13.439 -2.805 1.00 0.00 N
ATOM 780 N1 A A 36 42.993 -15.034 -1.942 1.00 0.00 N
ATOM 781 C2 A A 36 41.759 -15.435 -1.600 1.00 0.00 C
ATOM 782 N3 A A 36 40.703 -14.639 -1.784 1.00 0.00 N
ATOM 783 C4 A A 36 40.881 -13.378 -2.320 1.00 0.00 C
HETATM 784 N1 YG A 37 46.372 -14.527 1.026 1.00 0.00 N
HETATM 785 N2 YG A 37 46.596 -16.095 2.657 1.00 0.00 N
HETATM 786 C2 YG A 37 45.770 -15.207 2.030 1.00 0.00 C
HETATM 787 N3 YG A 37 44.469 -14.987 2.455 1.00 0.00 N
HETATM 788 C3 YG A 37 43.723 -16.080 3.095 1.00 0.00 C
HETATM 789 C4 YG A 37 43.838 -13.941 1.759 1.00 0.00 C
HETATM 790 C5 YG A 37 44.483 -13.219 0.750 1.00 0.00 C
HETATM 791 C6 YG A 37 45.770 -13.591 0.336 1.00 0.00 C
HETATM 792 O6 YG A 37 46.210 -13.216 -0.759 1.00 0.00 O
HETATM 793 N7 YG A 37 43.606 -12.250 0.257 1.00 0.00 N
HETATM 794 C8 YG A 37 42.419 -12.394 0.934 1.00 0.00 C
HETATM 795 N9 YG A 37 42.553 -13.408 1.851 1.00 0.00 N
HETATM 796 C10 YG A 37 49.079 -16.506 2.539 1.00 0.00 C
HETATM 797 C11 YG A 37 47.778 -15.986 2.007 1.00 0.00 C
HETATM 798 C12 YG A 37 47.640 -15.040 0.923 1.00 0.00 C
HETATM 799 C13 YG A 37 48.753 -14.676 -0.034 1.00 0.00 C
HETATM 800 C14 YG A 37 49.029 -15.924 -0.888 1.00 0.00 C
HETATM 801 C15 YG A 37 50.510 -16.234 -1.207 1.00 0.00 C
HETATM 802 C16 YG A 37 50.381 -17.342 -2.215 1.00 0.00 C
HETATM 803 O17 YG A 37 49.794 -18.389 -1.891 1.00 0.00 O
HETATM 804 O18 YG A 37 50.957 -17.258 -3.313 1.00 0.00 O
HETATM 805 C19 YG A 37 50.725 -18.442 -4.065 1.00 0.00 C
HETATM 806 N20 YG A 37 51.204 -16.761 0.017 1.00 0.00 N
HETATM 807 C21 YG A 37 52.320 -17.563 0.006 1.00 0.00 C
HETATM 808 O22 YG A 37 52.914 -17.835 -1.048 1.00 0.00 O
HETATM 809 O23 YG A 37 52.477 -18.345 0.958 1.00 0.00 O
HETATM 810 C24 YG A 37 53.613 -19.176 0.732 1.00 0.00 C
HETATM 811 C1' YG A 37 41.462 -13.888 2.757 1.00 0.00 C
HETATM 812 C2' YG A 37 41.762 -13.454 4.204 1.00 0.00 C
HETATM 813 O2' YG A 37 41.164 -14.324 5.148 1.00 0.00 O
HETATM 814 C3' YG A 37 41.178 -12.055 4.263 1.00 0.00 C
HETATM 815 O3' YG A 37 40.641 -11.669 5.518 1.00 0.00 O
HETATM 816 C4' YG A 37 40.017 -12.138 3.311 1.00 0.00 C
HETATM 817 O4' YG A 37 40.247 -13.216 2.397 1.00 0.00 O
HETATM 818 C5' YG A 37 39.976 -10.789 2.621 1.00 0.00 C
HETATM 819 O5' YG A 37 38.819 -10.817 1.841 1.00 0.00 O
HETATM 820 P YG A 37 38.123 -9.451 1.432 1.00 0.00 P
HETATM 821 OP1 YG A 37 37.039 -9.086 2.397 1.00 0.00 O
HETATM 822 OP2 YG A 37 39.170 -8.445 1.084 1.00 0.00 O
ATOM 823 P A A 38 41.099 -10.250 6.116 1.00 0.00 P
ATOM 824 OP1 A A 38 40.236 -9.917 7.275 1.00 0.00 O
ATOM 825 OP2 A A 38 41.273 -9.231 5.041 1.00 0.00 O
ATOM 826 O5' A A 38 42.532 -10.705 6.658 1.00 0.00 O
ATOM 827 C5' A A 38 42.584 -11.679 7.689 1.00 0.00 C
ATOM 828 C4' A A 38 43.910 -12.439 7.584 1.00 0.00 C
ATOM 829 O4' A A 38 44.015 -13.044 6.294 1.00 0.00 O
ATOM 830 C3' A A 38 45.138 -11.536 7.782 1.00 0.00 C
ATOM 831 O3' A A 38 45.463 -11.485 9.182 1.00 0.00 O
ATOM 832 C2' A A 38 46.177 -12.387 7.047 1.00 0.00 C
ATOM 833 O2' A A 38 46.755 -13.334 7.921 1.00 0.00 O
ATOM 834 C1' A A 38 45.401 -13.144 5.959 1.00 0.00 C
ATOM 835 N9 A A 38 45.635 -12.407 4.701 1.00 0.00 N
ATOM 836 C8 A A 38 44.750 -11.572 4.088 1.00 0.00 C
ATOM 837 N7 A A 38 45.390 -10.978 3.018 1.00 0.00 N
ATOM 838 C5 A A 38 46.696 -11.472 3.000 1.00 0.00 C
ATOM 839 C6 A A 38 47.837 -11.096 2.283 1.00 0.00 C
ATOM 840 N6 A A 38 47.797 -10.015 1.494 1.00 0.00 N
ATOM 841 N1 A A 38 49.004 -11.730 2.502 1.00 0.00 N
ATOM 842 C2 A A 38 49.103 -12.701 3.429 1.00 0.00 C
ATOM 843 N3 A A 38 48.049 -13.050 4.181 1.00 0.00 N
ATOM 844 C4 A A 38 46.823 -12.416 3.988 1.00 0.00 C
HETATM 845 N1 PSU A 39 46.862 -8.681 5.301 1.00 0.00 N
HETATM 846 C2 PSU A 39 47.232 -7.999 4.210 1.00 0.00 C
HETATM 847 N3 PSU A 39 48.499 -8.017 3.793 1.00 0.00 N
HETATM 848 C4 PSU A 39 49.436 -8.707 4.446 1.00 0.00 C
HETATM 849 C5 PSU A 39 49.090 -9.409 5.592 1.00 0.00 C
HETATM 850 C6 PSU A 39 47.755 -9.386 5.998 1.00 0.00 C
HETATM 851 O2 PSU A 39 46.361 -7.552 3.447 1.00 0.00 O
HETATM 852 O4 PSU A 39 50.631 -8.598 4.127 1.00 0.00 O
HETATM 853 C1' PSU A 39 50.140 -10.189 6.355 1.00 0.00 C
HETATM 854 C2' PSU A 39 50.874 -9.286 7.358 1.00 0.00 C
HETATM 855 O2' PSU A 39 52.269 -9.576 7.400 1.00 0.00 O
HETATM 856 C3' PSU A 39 50.254 -9.658 8.681 1.00 0.00 C
HETATM 857 C4' PSU A 39 49.886 -11.108 8.477 1.00 0.00 C
HETATM 858 O3' PSU A 39 51.222 -9.585 9.707 1.00 0.00 O
HETATM 859 O4' PSU A 39 49.518 -11.231 7.110 1.00 0.00 O
HETATM 860 C5' PSU A 39 48.677 -11.391 9.379 1.00 0.00 C
HETATM 861 O5' PSU A 39 47.717 -10.370 9.099 1.00 0.00 O
HETATM 862 P PSU A 39 46.305 -10.277 9.860 1.00 0.00 P
HETATM 863 OP1 PSU A 39 46.569 -10.534 11.301 1.00 0.00 O
HETATM 864 OP2 PSU A 39 45.625 -9.016 9.509 1.00 0.00 O
HETATM 865 P 5MC A 40 51.342 -8.221 10.528 1.00 0.00 P
HETATM 866 OP1 5MC A 40 52.332 -8.386 11.610 1.00 0.00 O
HETATM 867 OP2 5MC A 40 49.967 -7.819 10.898 1.00 0.00 O
HETATM 868 O5' 5MC A 40 51.912 -7.189 9.439 1.00 0.00 O
HETATM 869 C5' 5MC A 40 53.324 -6.981 9.359 1.00 0.00 C
HETATM 870 C4' 5MC A 40 53.689 -6.027 8.197 1.00 0.00 C
HETATM 871 O4' 5MC A 40 53.064 -6.476 6.997 1.00 0.00 O
HETATM 872 C3' 5MC A 40 53.245 -4.572 8.386 1.00 0.00 C
HETATM 873 O3' 5MC A 40 54.202 -3.811 9.135 1.00 0.00 O
HETATM 874 C2' 5MC A 40 53.346 -4.141 6.933 1.00 0.00 C
HETATM 875 O2' 5MC A 40 54.716 -3.965 6.618 1.00 0.00 O
HETATM 876 C1' 5MC A 40 52.849 -5.360 6.145 1.00 0.00 C
HETATM 877 N1 5MC A 40 51.392 -5.234 5.862 1.00 0.00 N
HETATM 878 C2 5MC A 40 50.988 -4.553 4.774 1.00 0.00 C
HETATM 879 O2 5MC A 40 51.777 -3.754 4.247 1.00 0.00 O
HETATM 880 N3 5MC A 40 49.681 -4.426 4.491 1.00 0.00 N
HETATM 881 C4 5MC A 40 48.746 -4.957 5.273 1.00 0.00 C
HETATM 882 N4 5MC A 40 47.473 -4.632 5.086 1.00 0.00 N
HETATM 883 C5 5MC A 40 49.136 -5.673 6.407 1.00 0.00 C
HETATM 884 C6 5MC A 40 50.500 -5.801 6.673 1.00 0.00 C
HETATM 885 CM5 5MC A 40 48.124 -6.078 7.444 1.00 0.00 C
ATOM 886 P U A 41 53.809 -2.389 9.850 1.00 0.00 P
ATOM 887 OP1 U A 41 55.009 -1.868 10.527 1.00 0.00 O
ATOM 888 OP2 U A 41 52.590 -2.564 10.659 1.00 0.00 O
ATOM 889 O5' U A 41 53.382 -1.415 8.631 1.00 0.00 O
ATOM 890 C5' U A 41 54.343 -0.818 7.770 1.00 0.00 C
ATOM 891 C4' U A 41 53.593 0.039 6.736 1.00 0.00 C
ATOM 892 O4' U A 41 52.552 -0.728 6.155 1.00 0.00 O
ATOM 893 C3' U A 41 52.808 1.145 7.393 1.00 0.00 C
ATOM 894 O3' U A 41 53.695 2.182 7.757 1.00 0.00 O
ATOM 895 C2' U A 41 51.917 1.541 6.225 1.00 0.00 C
ATOM 896 O2' U A 41 52.671 2.235 5.238 1.00 0.00 O
ATOM 897 C1' U A 41 51.583 0.174 5.643 1.00 0.00 C
ATOM 898 N1 U A 41 50.272 -0.322 6.090 1.00 0.00 N
ATOM 899 C2 U A 41 49.131 0.191 5.553 1.00 0.00 C
ATOM 900 O2 U A 41 49.191 1.124 4.734 1.00 0.00 O
ATOM 901 N3 U A 41 47.928 -0.285 5.898 1.00 0.00 N
ATOM 902 C4 U A 41 47.808 -1.288 6.773 1.00 0.00 C
ATOM 903 O4 U A 41 46.751 -1.938 6.779 1.00 0.00 O
ATOM 904 C5 U A 41 48.971 -1.846 7.346 1.00 0.00 C
ATOM 905 C6 U A 41 50.220 -1.336 6.958 1.00 0.00 C
ATOM 906 P G A 42 53.365 3.056 9.075 1.00 0.00 P
ATOM 907 OP1 G A 42 54.509 3.991 9.203 1.00 0.00 O
ATOM 908 OP2 G A 42 52.947 2.165 10.213 1.00 0.00 O
ATOM 909 O5' G A 42 52.127 3.881 8.529 1.00 0.00 O
ATOM 910 C5' G A 42 52.403 4.860 7.543 1.00 0.00 C
ATOM 911 C4' G A 42 51.077 5.396 7.023 1.00 0.00 C
ATOM 912 O4' G A 42 50.355 4.386 6.338 1.00 0.00 O
ATOM 913 C3' G A 42 50.179 5.806 8.165 1.00 0.00 C
ATOM 914 O3' G A 42 50.604 7.046 8.727 1.00 0.00 O
ATOM 915 C2' G A 42 48.896 5.925 7.371 1.00 0.00 C
ATOM 916 O2' G A 42 48.946 7.071 6.542 1.00 0.00 O
ATOM 917 C1' G A 42 48.974 4.686 6.480 1.00 0.00 C
ATOM 918 N9 G A 42 48.278 3.580 7.167 1.00 0.00 N
ATOM 919 C8 G A 42 48.814 2.607 7.981 1.00 0.00 C
ATOM 920 N7 G A 42 47.766 1.808 8.439 1.00 0.00 N
ATOM 921 C5 G A 42 46.606 2.358 7.905 1.00 0.00 C
ATOM 922 C6 G A 42 45.269 2.030 8.038 1.00 0.00 C
ATOM 923 O6 G A 42 44.971 0.909 8.471 1.00 0.00 O
ATOM 924 N1 G A 42 44.343 2.785 7.417 1.00 0.00 N
ATOM 925 C2 G A 42 44.683 3.838 6.662 1.00 0.00 C
ATOM 926 N2 G A 42 43.761 4.501 5.998 1.00 0.00 N
ATOM 927 N3 G A 42 45.944 4.170 6.498 1.00 0.00 N
ATOM 928 C4 G A 42 46.926 3.427 7.120 1.00 0.00 C
ATOM 929 P G A 43 50.051 7.500 10.169 1.00 0.00 P
ATOM 930 OP1 G A 43 50.843 8.647 10.660 1.00 0.00 O
ATOM 931 OP2 G A 43 49.913 6.296 11.052 1.00 0.00 O
ATOM 932 O5' G A 43 48.619 8.027 9.726 1.00 0.00 O
ATOM 933 C5' G A 43 48.473 9.257 9.050 1.00 0.00 C
ATOM 934 C4' G A 43 46.999 9.300 8.688 1.00 0.00 C
ATOM 935 O4' G A 43 46.642 7.985 8.246 1.00 0.00 O
ATOM 936 C3' G A 43 46.145 9.498 9.937 1.00 0.00 C
ATOM 937 O3' G A 43 46.072 10.883 10.285 1.00 0.00 O
ATOM 938 C2' G A 43 44.822 8.985 9.368 1.00 0.00 C
ATOM 939 O2' G A 43 44.271 9.972 8.507 1.00 0.00 O
ATOM 940 C1' G A 43 45.243 7.783 8.502 1.00 0.00 C
ATOM 941 N9 G A 43 45.101 6.525 9.271 1.00 0.00 N
ATOM 942 C8 G A 43 46.112 5.912 9.945 1.00 0.00 C
ATOM 943 N7 G A 43 45.622 4.788 10.567 1.00 0.00 N
ATOM 944 C5 G A 43 44.274 4.747 10.276 1.00 0.00 C
ATOM 945 C6 G A 43 43.296 3.850 10.658 1.00 0.00 C
ATOM 946 O6 G A 43 43.645 2.759 11.141 1.00 0.00 O
ATOM 947 N1 G A 43 42.035 4.044 10.263 1.00 0.00 N
ATOM 948 C2 G A 43 41.690 5.073 9.488 1.00 0.00 C
ATOM 949 N2 G A 43 40.398 5.283 9.260 1.00 0.00 N
ATOM 950 N3 G A 43 42.613 5.960 9.066 1.00 0.00 N
ATOM 951 C4 G A 43 43.937 5.801 9.463 1.00 0.00 C
ATOM 952 P A A 44 45.632 11.343 11.777 1.00 0.00 P
ATOM 953 OP1 A A 44 45.829 12.790 11.905 1.00 0.00 O
ATOM 954 OP2 A A 44 46.243 10.413 12.782 1.00 0.00 O
ATOM 955 O5' A A 44 44.053 11.119 11.766 1.00 0.00 O
ATOM 956 C5' A A 44 43.216 11.971 10.996 1.00 0.00 C
ATOM 957 C4' A A 44 41.830 11.298 10.891 1.00 0.00 C
ATOM 958 O4' A A 44 42.033 9.947 10.502 1.00 0.00 O
ATOM 959 C3' A A 44 41.127 11.194 12.247 1.00 0.00 C
ATOM 960 O3' A A 44 40.364 12.349 12.529 1.00 0.00 O
ATOM 961 C2' A A 44 40.186 10.015 12.008 1.00 0.00 C
ATOM 962 O2' A A 44 39.106 10.352 11.154 1.00 0.00 O
ATOM 963 C1' A A 44 41.075 9.123 11.185 1.00 0.00 C
ATOM 964 N9 A A 44 41.772 8.182 12.070 1.00 0.00 N
ATOM 965 C8 A A 44 43.100 8.179 12.346 1.00 0.00 C
ATOM 966 N7 A A 44 43.387 7.034 13.057 1.00 0.00 N
ATOM 967 C5 A A 44 42.214 6.303 13.116 1.00 0.00 C
ATOM 968 C6 A A 44 41.953 4.992 13.493 1.00 0.00 C
ATOM 969 N6 A A 44 42.851 4.318 14.198 1.00 0.00 N
ATOM 970 N1 A A 44 40.739 4.502 13.339 1.00 0.00 N
ATOM 971 C2 A A 44 39.754 5.237 12.818 1.00 0.00 C
ATOM 972 N3 A A 44 39.956 6.475 12.432 1.00 0.00 N
ATOM 973 C4 A A 44 41.209 7.035 12.568 1.00 0.00 C
ATOM 974 P G A 45 40.314 12.923 14.024 1.00 0.00 P
ATOM 975 OP1 G A 45 39.241 13.968 14.100 1.00 0.00 O
ATOM 976 OP2 G A 45 41.716 13.256 14.385 1.00 0.00 O
ATOM 977 O5' G A 45 39.819 11.677 14.882 1.00 0.00 O
ATOM 978 C5' G A 45 38.436 11.344 14.886 1.00 0.00 C
ATOM 979 C4' G A 45 38.251 10.046 15.680 1.00 0.00 C
ATOM 980 O4' G A 45 39.192 9.073 15.231 1.00 0.00 O
ATOM 981 C3' G A 45 38.582 10.217 17.156 1.00 0.00 C
ATOM 982 O3' G A 45 37.448 10.726 17.830 1.00 0.00 O
ATOM 983 C2' G A 45 38.747 8.756 17.537 1.00 0.00 C
ATOM 984 O2' G A 45 37.445 8.195 17.638 1.00 0.00 O
ATOM 985 C1' G A 45 39.402 8.140 16.290 1.00 0.00 C
ATOM 986 N9 G A 45 40.863 7.946 16.416 1.00 0.00 N
ATOM 987 C8 G A 45 41.809 8.836 16.018 1.00 0.00 C
ATOM 988 N7 G A 45 43.053 8.302 16.262 1.00 0.00 N
ATOM 989 C5 G A 45 42.842 7.023 16.767 1.00 0.00 C
ATOM 990 C6 G A 45 43.720 6.011 17.163 1.00 0.00 C
ATOM 991 O6 G A 45 44.944 6.218 17.201 1.00 0.00 O
ATOM 992 N1 G A 45 43.232 4.861 17.612 1.00 0.00 N
ATOM 993 C2 G A 45 41.914 4.626 17.667 1.00 0.00 C
ATOM 994 N2 G A 45 41.485 3.493 18.226 1.00 0.00 N
ATOM 995 N3 G A 45 41.028 5.562 17.278 1.00 0.00 N
ATOM 996 C4 G A 45 41.488 6.788 16.831 1.00 0.00 C
HETATM 997 P 7MG A 46 37.547 12.150 18.559 1.00 0.00 P
HETATM 998 OP1 7MG A 46 36.562 13.047 17.929 1.00 0.00 O
HETATM 999 OP2 7MG A 46 38.940 12.638 18.636 1.00 0.00 O
HETATM 1000 O5' 7MG A 46 37.078 11.760 20.038 1.00 0.00 O
HETATM 1001 C5' 7MG A 46 37.855 10.769 20.677 1.00 0.00 C
HETATM 1002 C4' 7MG A 46 37.584 10.772 22.175 1.00 0.00 C
HETATM 1003 O4' 7MG A 46 38.798 10.250 22.723 1.00 0.00 O
HETATM 1004 C3' 7MG A 46 37.528 12.257 22.581 1.00 0.00 C
HETATM 1005 O3' 7MG A 46 36.969 12.471 23.874 1.00 0.00 O
HETATM 1006 C2' 7MG A 46 38.992 12.648 22.633 1.00 0.00 C
HETATM 1007 O2' 7MG A 46 39.206 13.619 23.658 1.00 0.00 O
HETATM 1008 C1' 7MG A 46 39.605 11.349 23.112 1.00 0.00 C
HETATM 1009 N9 7MG A 46 40.996 11.220 22.721 1.00 0.00 N
HETATM 1010 C8 7MG A 46 41.724 12.149 22.057 1.00 0.00 C
HETATM 1011 N7 7MG A 46 42.975 11.664 21.911 1.00 0.00 N
HETATM 1012 C5 7MG A 46 43.024 10.436 22.569 1.00 0.00 C
HETATM 1013 C6 7MG A 46 43.990 9.436 22.687 1.00 0.00 C
HETATM 1014 O6 7MG A 46 45.178 9.705 22.489 1.00 0.00 O
HETATM 1015 N1 7MG A 46 43.698 8.336 23.374 1.00 0.00 N
HETATM 1016 C2 7MG A 46 42.514 8.146 23.936 1.00 0.00 C
HETATM 1017 N2 7MG A 46 42.349 7.149 24.774 1.00 0.00 N
HETATM 1018 N3 7MG A 46 41.564 9.038 23.810 1.00 0.00 N
HETATM 1019 C4 7MG A 46 41.799 10.189 23.093 1.00 0.00 C
HETATM 1020 CM7 7MG A 46 44.134 12.551 21.742 1.00 0.00 C
ATOM 1021 P U A 47 35.389 12.461 24.245 1.00 0.00 P
ATOM 1022 OP1 U A 47 34.996 11.216 24.927 1.00 0.00 O
ATOM 1023 OP2 U A 47 34.526 12.920 23.127 1.00 0.00 O
ATOM 1024 O5' U A 47 35.447 13.600 25.319 1.00 0.00 O
ATOM 1025 C5' U A 47 36.448 13.468 26.302 1.00 0.00 C
ATOM 1026 C4' U A 47 36.723 14.876 26.759 1.00 0.00 C
ATOM 1027 O4' U A 47 35.507 15.611 26.687 1.00 0.00 O
ATOM 1028 C3' U A 47 37.208 14.898 28.198 1.00 0.00 C
ATOM 1029 O3' U A 47 38.634 14.908 28.167 1.00 0.00 O
ATOM 1030 C2' U A 47 36.674 16.256 28.641 1.00 0.00 C
ATOM 1031 O2' U A 47 37.602 17.301 28.341 1.00 0.00 O
ATOM 1032 C1' U A 47 35.396 16.473 27.821 1.00 0.00 C
ATOM 1033 N1 U A 47 34.142 16.111 28.546 1.00 0.00 N
ATOM 1034 C2 U A 47 33.917 16.537 29.812 1.00 0.00 C
ATOM 1035 O2 U A 47 34.656 17.404 30.314 1.00 0.00 O
ATOM 1036 N3 U A 47 32.761 16.239 30.434 1.00 0.00 N
ATOM 1037 C4 U A 47 31.795 15.552 29.814 1.00 0.00 C
ATOM 1038 O4 U A 47 30.776 15.202 30.431 1.00 0.00 O
ATOM 1039 C5 U A 47 31.984 15.137 28.506 1.00 0.00 C
ATOM 1040 C6 U A 47 33.188 15.449 27.883 1.00 0.00 C
ATOM 1041 P C A 48 39.512 15.072 29.497 1.00 0.00 P
ATOM 1042 OP1 C A 48 38.868 16.000 30.467 1.00 0.00 O
ATOM 1043 OP2 C A 48 40.853 15.564 29.087 1.00 0.00 O
ATOM 1044 O5' C A 48 39.706 13.594 30.141 1.00 0.00 O
ATOM 1045 C5' C A 48 38.811 12.499 30.014 1.00 0.00 C
ATOM 1046 C4' C A 48 39.619 11.249 30.376 1.00 0.00 C
ATOM 1047 O4' C A 48 40.844 11.341 29.678 1.00 0.00 O
ATOM 1048 C3' C A 48 39.995 11.224 31.870 1.00 0.00 C
ATOM 1049 O3' C A 48 39.885 9.878 32.334 1.00 0.00 O
ATOM 1050 C2' C A 48 41.476 11.535 31.881 1.00 0.00 C
ATOM 1051 O2' C A 48 42.083 10.803 32.943 1.00 0.00 O
ATOM 1052 C1' C A 48 41.869 10.902 30.554 1.00 0.00 C
ATOM 1053 N1 C A 48 43.167 11.406 30.062 1.00 0.00 N
ATOM 1054 C2 C A 48 44.269 10.623 30.074 1.00 0.00 C
ATOM 1055 O2 C A 48 44.281 9.571 30.736 1.00 0.00 O
ATOM 1056 N3 C A 48 45.429 11.091 29.613 1.00 0.00 N
ATOM 1057 C4 C A 48 45.532 12.324 29.132 1.00 0.00 C
ATOM 1058 N4 C A 48 46.686 12.754 28.614 1.00 0.00 N
ATOM 1059 C5 C A 48 44.409 13.131 29.092 1.00 0.00 C
ATOM 1060 C6 C A 48 43.213 12.627 29.559 1.00 0.00 C
HETATM 1061 P 5MC A 49 39.469 9.595 33.844 1.00 0.00 P
HETATM 1062 OP1 5MC A 49 39.689 10.824 34.613 1.00 0.00 O
HETATM 1063 OP2 5MC A 49 40.132 8.383 34.349 1.00 0.00 O
HETATM 1064 O5' 5MC A 49 37.915 9.241 33.750 1.00 0.00 O
HETATM 1065 C5' 5MC A 49 37.117 9.771 32.702 1.00 0.00 C
HETATM 1066 C4' 5MC A 49 35.678 10.011 33.189 1.00 0.00 C
HETATM 1067 O4' 5MC A 49 35.242 9.056 34.163 1.00 0.00 O
HETATM 1068 C3' 5MC A 49 35.636 11.340 33.879 1.00 0.00 C
HETATM 1069 O3' 5MC A 49 35.560 12.318 32.867 1.00 0.00 O
HETATM 1070 C2' 5MC A 49 34.317 11.161 34.592 1.00 0.00 C
HETATM 1071 O2' 5MC A 49 33.259 11.220 33.689 1.00 0.00 O
HETATM 1072 C1' 5MC A 49 34.393 9.724 35.094 1.00 0.00 C
HETATM 1073 N1 5MC A 49 35.074 9.739 36.407 1.00 0.00 N
HETATM 1074 C2 5MC A 49 34.392 10.087 37.499 1.00 0.00 C
HETATM 1075 O2 5MC A 49 33.268 10.591 37.380 1.00 0.00 O
HETATM 1076 N3 5MC A 49 34.969 10.080 38.714 1.00 0.00 N
HETATM 1077 C4 5MC A 49 36.236 9.754 38.864 1.00 0.00 C
HETATM 1078 N4 5MC A 49 36.819 9.917 40.029 1.00 0.00 N
HETATM 1079 C5 5MC A 49 36.983 9.417 37.754 1.00 0.00 C
HETATM 1080 C6 5MC A 49 36.355 9.411 36.499 1.00 0.00 C
HETATM 1081 CM5 5MC A 49 38.479 9.334 37.866 1.00 0.00 C
ATOM 1082 P U A 50 36.094 13.806 33.091 1.00 0.00 P
ATOM 1083 OP1 U A 50 36.011 14.496 31.817 1.00 0.00 O
ATOM 1084 OP2 U A 50 37.423 13.721 33.731 1.00 0.00 O
ATOM 1085 O5' U A 50 35.002 14.457 34.075 1.00 0.00 O
ATOM 1086 C5' U A 50 33.676 14.729 33.633 1.00 0.00 C
ATOM 1087 C4' U A 50 32.818 15.350 34.763 1.00 0.00 C
ATOM 1088 O4' U A 50 32.688 14.437 35.839 1.00 0.00 O
ATOM 1089 C3' U A 50 33.510 16.573 35.324 1.00 0.00 C
ATOM 1090 O3' U A 50 33.176 17.742 34.577 1.00 0.00 O
ATOM 1091 C2' U A 50 32.930 16.609 36.730 1.00 0.00 C
ATOM 1092 O2' U A 50 31.647 17.199 36.732 1.00 0.00 O
ATOM 1093 C1' U A 50 32.775 15.127 37.077 1.00 0.00 C
ATOM 1094 N1 U A 50 33.964 14.673 37.824 1.00 0.00 N
ATOM 1095 C2 U A 50 34.165 15.136 39.066 1.00 0.00 C
ATOM 1096 O2 U A 50 33.298 15.820 39.617 1.00 0.00 O
ATOM 1097 N3 U A 50 35.219 14.775 39.777 1.00 0.00 N
ATOM 1098 C4 U A 50 36.116 13.945 39.295 1.00 0.00 C
ATOM 1099 O4 U A 50 36.798 13.302 40.110 1.00 0.00 O
ATOM 1100 C5 U A 50 35.941 13.456 37.999 1.00 0.00 C
ATOM 1101 C6 U A 50 34.821 13.849 37.279 1.00 0.00 C
ATOM 1102 P G A 51 34.176 19.001 34.678 1.00 0.00 P
ATOM 1103 OP1 G A 51 33.768 19.990 33.684 1.00 0.00 O
ATOM 1104 OP2 G A 51 35.594 18.552 34.642 1.00 0.00 O
ATOM 1105 O5' G A 51 33.928 19.580 36.141 1.00 0.00 O
ATOM 1106 C5' G A 51 32.813 20.408 36.462 1.00 0.00 C
ATOM 1107 C4' G A 51 32.897 20.769 37.954 1.00 0.00 C
ATOM 1108 O4' G A 51 33.004 19.561 38.696 1.00 0.00 O
ATOM 1109 C3' G A 51 34.174 21.533 38.295 1.00 0.00 C
ATOM 1110 O3' G A 51 34.027 22.930 38.076 1.00 0.00 O
ATOM 1111 C2' G A 51 34.286 21.237 39.777 1.00 0.00 C
ATOM 1112 O2' G A 51 33.478 22.075 40.561 1.00 0.00 O
ATOM 1113 C1' G A 51 33.733 19.824 39.892 1.00 0.00 C
ATOM 1114 N9 G A 51 34.887 18.943 39.913 1.00 0.00 N
ATOM 1115 C8 G A 51 35.449 18.344 38.849 1.00 0.00 C
ATOM 1116 N7 G A 51 36.505 17.610 39.286 1.00 0.00 N
ATOM 1117 C5 G A 51 36.609 17.831 40.648 1.00 0.00 C
ATOM 1118 C6 G A 51 37.439 17.309 41.620 1.00 0.00 C
ATOM 1119 O6 G A 51 37.930 16.196 41.421 1.00 0.00 O
ATOM 1120 N1 G A 51 37.308 17.741 42.873 1.00 0.00 N
ATOM 1121 C2 G A 51 36.384 18.630 43.214 1.00 0.00 C
ATOM 1122 N2 G A 51 36.290 19.028 44.455 1.00 0.00 N
ATOM 1123 N3 G A 51 35.552 19.104 42.333 1.00 0.00 N
ATOM 1124 C4 G A 51 35.639 18.689 41.025 1.00 0.00 C
ATOM 1125 P U A 52 35.343 23.812 37.825 1.00 0.00 P
ATOM 1126 OP1 U A 52 34.957 25.168 37.391 1.00 0.00 O
ATOM 1127 OP2 U A 52 36.242 22.981 36.975 1.00 0.00 O
ATOM 1128 O5' U A 52 35.970 23.942 39.274 1.00 0.00 O
ATOM 1129 C5' U A 52 35.384 24.853 40.192 1.00 0.00 C
ATOM 1130 C4' U A 52 35.971 24.542 41.563 1.00 0.00 C
ATOM 1131 O4' U A 52 36.054 23.119 41.679 1.00 0.00 O
ATOM 1132 C3' U A 52 37.415 24.977 41.681 1.00 0.00 C
ATOM 1133 O3' U A 52 37.628 26.350 42.014 1.00 0.00 O
ATOM 1134 C2' U A 52 37.826 24.119 42.859 1.00 0.00 C
ATOM 1135 O2' U A 52 37.434 24.764 44.060 1.00 0.00 O
ATOM 1136 C1' U A 52 37.050 22.820 42.642 1.00 0.00 C
ATOM 1137 N1 U A 52 37.949 21.815 42.063 1.00 0.00 N
ATOM 1138 C2 U A 52 38.798 21.157 42.858 1.00 0.00 C
ATOM 1139 O2 U A 52 38.849 21.426 44.072 1.00 0.00 O
ATOM 1140 N3 U A 52 39.649 20.268 42.358 1.00 0.00 N
ATOM 1141 C4 U A 52 39.674 19.979 41.068 1.00 0.00 C
ATOM 1142 O4 U A 52 40.329 18.996 40.679 1.00 0.00 O
ATOM 1143 C5 U A 52 38.771 20.614 40.211 1.00 0.00 C
ATOM 1144 C6 U A 52 37.893 21.544 40.756 1.00 0.00 C
ATOM 1145 P G A 53 39.095 26.932 41.612 1.00 0.00 P
ATOM 1146 OP1 G A 53 39.149 28.384 41.933 1.00 0.00 O
ATOM 1147 OP2 G A 53 39.366 26.466 40.217 1.00 0.00 O
ATOM 1148 O5' G A 53 40.171 26.166 42.523 1.00 0.00 O
ATOM 1149 C5' G A 53 40.462 26.653 43.810 1.00 0.00 C
ATOM 1150 C4' G A 53 41.311 25.616 44.546 1.00 0.00 C
ATOM 1151 O4' G A 53 40.915 24.310 44.181 1.00 0.00 O
ATOM 1152 C3' G A 53 42.761 25.642 44.180 1.00 0.00 C
ATOM 1153 O3' G A 53 43.417 26.681 44.873 1.00 0.00 O
ATOM 1154 C2' G A 53 43.164 24.333 44.811 1.00 0.00 C
ATOM 1155 O2' G A 53 43.188 24.515 46.210 1.00 0.00 O
ATOM 1156 C1' G A 53 41.994 23.437 44.448 1.00 0.00 C
ATOM 1157 N9 G A 53 42.298 22.705 43.216 1.00 0.00 N
ATOM 1158 C8 G A 53 41.693 22.866 42.021 1.00 0.00 C
ATOM 1159 N7 G A 53 42.241 21.967 41.132 1.00 0.00 N
ATOM 1160 C5 G A 53 43.239 21.274 41.813 1.00 0.00 C
ATOM 1161 C6 G A 53 44.071 20.201 41.470 1.00 0.00 C
ATOM 1162 O6 G A 53 43.853 19.533 40.443 1.00 0.00 O
ATOM 1163 N1 G A 53 44.967 19.764 42.352 1.00 0.00 N
ATOM 1164 C2 G A 53 45.071 20.305 43.572 1.00 0.00 C
ATOM 1165 N2 G A 53 46.193 20.129 44.261 1.00 0.00 N
ATOM 1166 N3 G A 53 44.259 21.274 43.952 1.00 0.00 N
ATOM 1167 C4 G A 53 43.308 21.774 43.078 1.00 0.00 C
HETATM 1168 N1 5MU A 54 47.464 22.781 42.919 1.00 0.00 N
HETATM 1169 C2 5MU A 54 47.858 21.757 42.128 1.00 0.00 C
HETATM 1170 N3 5MU A 54 47.337 21.610 40.899 1.00 0.00 N
HETATM 1171 C4 5MU A 54 46.406 22.446 40.435 1.00 0.00 C
HETATM 1172 C5 5MU A 54 45.952 23.475 41.248 1.00 0.00 C
HETATM 1173 C5M 5MU A 54 44.740 24.261 40.866 1.00 0.00 C
HETATM 1174 C6 5MU A 54 46.497 23.610 42.514 1.00 0.00 C
HETATM 1175 O2 5MU A 54 48.583 20.847 42.595 1.00 0.00 O
HETATM 1176 O4 5MU A 54 45.973 22.326 39.274 1.00 0.00 O
HETATM 1177 C1' 5MU A 54 48.031 22.920 44.291 1.00 0.00 C
HETATM 1178 C2' 5MU A 54 49.186 23.907 44.295 1.00 0.00 C
HETATM 1179 O2' 5MU A 54 50.055 23.620 45.369 1.00 0.00 O
HETATM 1180 C3' 5MU A 54 48.514 25.226 44.614 1.00 0.00 C
HETATM 1181 C4' 5MU A 54 47.481 24.755 45.624 1.00 0.00 C
HETATM 1182 O3' 5MU A 54 49.487 26.030 45.241 1.00 0.00 O
HETATM 1183 O4' 5MU A 54 47.030 23.493 45.149 1.00 0.00 O
HETATM 1184 C5' 5MU A 54 46.317 25.741 45.779 1.00 0.00 C
HETATM 1185 O5' 5MU A 54 45.763 26.027 44.507 1.00 0.00 O
HETATM 1186 P 5MU A 54 44.776 27.254 44.271 1.00 0.00 P
HETATM 1187 OP1 5MU A 54 45.165 28.396 45.104 1.00 0.00 O
HETATM 1188 OP2 5MU A 54 44.642 27.451 42.810 1.00 0.00 O
HETATM 1189 N1 PSU A 55 48.050 25.876 39.887 1.00 0.00 N
HETATM 1190 C2 PSU A 55 47.598 25.286 38.777 1.00 0.00 C
HETATM 1191 N3 PSU A 55 48.283 24.281 38.221 1.00 0.00 N
HETATM 1192 C4 PSU A 55 49.436 23.867 38.731 1.00 0.00 C
HETATM 1193 C5 PSU A 55 49.942 24.469 39.863 1.00 0.00 C
HETATM 1194 C6 PSU A 55 49.198 25.494 40.447 1.00 0.00 C
HETATM 1195 O2 PSU A 55 46.732 25.866 38.100 1.00 0.00 O
HETATM 1196 O4 PSU A 55 50.112 23.017 38.146 1.00 0.00 O
HETATM 1197 C1' PSU A 55 51.278 24.026 40.413 1.00 0.00 C
HETATM 1198 C2' PSU A 55 52.379 25.010 39.948 1.00 0.00 C
HETATM 1199 O2' PSU A 55 53.613 24.339 39.942 1.00 0.00 O
HETATM 1200 C3' PSU A 55 52.463 25.958 41.107 1.00 0.00 C
HETATM 1201 C4' PSU A 55 52.335 24.933 42.218 1.00 0.00 C
HETATM 1202 O3' PSU A 55 53.752 26.543 41.161 1.00 0.00 O
HETATM 1203 O4' PSU A 55 51.250 24.110 41.829 1.00 0.00 O
HETATM 1204 C5' PSU A 55 52.028 25.646 43.518 1.00 0.00 C
HETATM 1205 O5' PSU A 55 50.913 26.466 43.248 1.00 0.00 O
HETATM 1206 P PSU A 55 50.137 27.236 44.414 1.00 0.00 P
HETATM 1207 OP1 PSU A 55 51.105 27.968 45.281 1.00 0.00 O
HETATM 1208 OP2 PSU A 55 49.044 28.028 43.770 1.00 0.00 O
ATOM 1209 P C A 56 53.879 28.091 40.838 1.00 0.00 P
ATOM 1210 OP1 C A 56 55.143 28.534 41.450 1.00 0.00 O
ATOM 1211 OP2 C A 56 52.593 28.739 41.161 1.00 0.00 O
ATOM 1212 O5' C A 56 54.081 28.120 39.268 1.00 0.00 O
ATOM 1213 C5' C A 56 53.922 29.367 38.606 1.00 0.00 C
ATOM 1214 C4' C A 56 53.985 29.094 37.113 1.00 0.00 C
ATOM 1215 O4' C A 56 55.302 28.609 36.860 1.00 0.00 O
ATOM 1216 C3' C A 56 53.025 27.968 36.727 1.00 0.00 C
ATOM 1217 O3' C A 56 51.737 28.473 36.350 1.00 0.00 O
ATOM 1218 C2' C A 56 53.740 27.517 35.464 1.00 0.00 C
ATOM 1219 O2' C A 56 53.453 28.509 34.475 1.00 0.00 O
ATOM 1220 C1' C A 56 55.223 27.625 35.832 1.00 0.00 C
ATOM 1221 N1 C A 56 55.921 26.357 36.287 1.00 0.00 N
ATOM 1222 C2 C A 56 56.365 25.492 35.387 1.00 0.00 C
ATOM 1223 O2 C A 56 56.041 25.647 34.205 1.00 0.00 O
ATOM 1224 N3 C A 56 57.045 24.417 35.732 1.00 0.00 N
ATOM 1225 C4 C A 56 57.359 24.177 36.946 1.00 0.00 C
ATOM 1226 N4 C A 56 58.231 23.218 37.212 1.00 0.00 N
ATOM 1227 C5 C A 56 57.001 25.076 37.906 1.00 0.00 C
ATOM 1228 C6 C A 56 56.289 26.195 37.550 1.00 0.00 C
ATOM 1229 P G A 57 50.439 27.548 36.613 1.00 0.00 P
ATOM 1230 OP1 G A 57 49.193 28.099 35.983 1.00 0.00 O
ATOM 1231 OP2 G A 57 50.422 27.319 38.048 1.00 0.00 O
ATOM 1232 O5' G A 57 50.832 26.230 35.822 1.00 0.00 O
ATOM 1233 C5' G A 57 50.043 25.868 34.688 1.00 0.00 C
ATOM 1234 C4' G A 57 50.769 24.776 33.885 1.00 0.00 C
ATOM 1235 O4' G A 57 52.143 24.795 34.204 1.00 0.00 O
ATOM 1236 C3' G A 57 50.323 23.381 34.205 1.00 0.00 C
ATOM 1237 O3' G A 57 49.263 23.080 33.342 1.00 0.00 O
ATOM 1238 C2' G A 57 51.496 22.625 33.674 1.00 0.00 C
ATOM 1239 O2' G A 57 51.386 22.686 32.284 1.00 0.00 O
ATOM 1240 C1' G A 57 52.672 23.486 34.059 1.00 0.00 C
ATOM 1241 N9 G A 57 53.226 23.103 35.366 1.00 0.00 N
ATOM 1242 C8 G A 57 53.130 23.837 36.491 1.00 0.00 C
ATOM 1243 N7 G A 57 53.842 23.210 37.476 1.00 0.00 N
ATOM 1244 C5 G A 57 54.387 22.068 36.919 1.00 0.00 C
ATOM 1245 C6 G A 57 55.295 21.123 37.393 1.00 0.00 C
ATOM 1246 O6 G A 57 56.019 21.401 38.355 1.00 0.00 O
ATOM 1247 N1 G A 57 55.631 20.112 36.610 1.00 0.00 N
ATOM 1248 C2 G A 57 55.159 20.008 35.371 1.00 0.00 C
ATOM 1249 N2 G A 57 55.333 18.894 34.704 1.00 0.00 N
ATOM 1250 N3 G A 57 54.361 20.908 34.873 1.00 0.00 N
ATOM 1251 C4 G A 57 53.957 21.978 35.639 1.00 0.00 C
HETATM 1252 P 1MA A 58 47.841 22.745 33.940 1.00 0.00 P
HETATM 1253 OP1 1MA A 58 46.802 23.335 33.071 1.00 0.00 O
HETATM 1254 OP2 1MA A 58 47.837 22.995 35.376 1.00 0.00 O
HETATM 1255 O5' 1MA A 58 47.714 21.197 33.730 1.00 0.00 O
HETATM 1256 C5' 1MA A 58 48.698 20.345 34.238 1.00 0.00 C
HETATM 1257 C4' 1MA A 58 48.275 18.905 34.015 1.00 0.00 C
HETATM 1258 O4' 1MA A 58 48.785 18.312 35.192 1.00 0.00 O
HETATM 1259 C3' 1MA A 58 46.746 18.816 34.143 1.00 0.00 C
HETATM 1260 O3' 1MA A 58 46.254 17.531 33.799 1.00 0.00 O
HETATM 1261 C2' 1MA A 58 46.562 18.914 35.632 1.00 0.00 C
HETATM 1262 O2' 1MA A 58 45.388 18.228 35.967 1.00 0.00 O
HETATM 1263 C1' 1MA A 58 47.713 18.070 36.086 1.00 0.00 C
HETATM 1264 N9 1MA A 58 48.117 18.387 37.433 1.00 0.00 N
HETATM 1265 C8 1MA A 58 47.686 19.455 38.151 1.00 0.00 C
HETATM 1266 N7 1MA A 58 48.302 19.430 39.380 1.00 0.00 N
HETATM 1267 C5 1MA A 58 49.119 18.305 39.391 1.00 0.00 C
HETATM 1268 C6 1MA A 58 49.979 17.774 40.355 1.00 0.00 C
HETATM 1269 N6 1MA A 58 50.083 18.352 41.541 1.00 0.00 N
HETATM 1270 N1 1MA A 58 50.654 16.659 40.093 1.00 0.00 N
HETATM 1271 CM1 1MA A 58 51.535 16.107 41.118 1.00 0.00 C
HETATM 1272 C2 1MA A 58 50.535 16.035 38.915 1.00 0.00 C
HETATM 1273 N3 1MA A 58 49.749 16.501 37.964 1.00 0.00 N
HETATM 1274 C4 1MA A 58 49.013 17.658 38.185 1.00 0.00 C
ATOM 1275 P U A 59 46.385 16.863 32.340 1.00 0.00 P
ATOM 1276 OP1 U A 59 47.792 16.620 31.985 1.00 0.00 O
ATOM 1277 OP2 U A 59 45.538 17.633 31.424 1.00 0.00 O
ATOM 1278 O5' U A 59 45.751 15.402 32.554 1.00 0.00 O
ATOM 1279 C5' U A 59 44.488 15.209 33.184 1.00 0.00 C
ATOM 1280 C4' U A 59 44.403 13.727 33.555 1.00 0.00 C
ATOM 1281 O4' U A 59 45.121 12.981 32.583 1.00 0.00 O
ATOM 1282 C3' U A 59 45.163 13.393 34.825 1.00 0.00 C
ATOM 1283 O3' U A 59 44.341 13.589 35.956 1.00 0.00 O
ATOM 1284 C2' U A 59 45.301 11.901 34.651 1.00 0.00 C
ATOM 1285 O2' U A 59 44.004 11.406 34.857 1.00 0.00 O
ATOM 1286 C1' U A 59 45.559 11.757 33.164 1.00 0.00 C
ATOM 1287 N1 U A 59 46.986 11.600 32.815 1.00 0.00 N
ATOM 1288 C2 U A 59 47.676 10.551 33.256 1.00 0.00 C
ATOM 1289 O2 U A 59 47.061 9.598 33.757 1.00 0.00 O
ATOM 1290 N3 U A 59 48.959 10.374 32.899 1.00 0.00 N
ATOM 1291 C4 U A 59 49.571 11.210 32.078 1.00 0.00 C
ATOM 1292 O4 U A 59 50.791 11.108 31.895 1.00 0.00 O
ATOM 1293 C5 U A 59 48.880 12.304 31.571 1.00 0.00 C
ATOM 1294 C6 U A 59 47.557 12.477 31.969 1.00 0.00 C
ATOM 1295 P C A 60 44.981 14.487 37.100 1.00 0.00 P
ATOM 1296 OP1 C A 60 44.054 14.679 38.202 1.00 0.00 O
ATOM 1297 OP2 C A 60 45.538 15.664 36.453 1.00 0.00 O
ATOM 1298 O5' C A 60 46.168 13.557 37.560 1.00 0.00 O
ATOM 1299 C5' C A 60 45.853 12.329 38.229 1.00 0.00 C
ATOM 1300 C4' C A 60 47.150 11.531 38.542 1.00 0.00 C
ATOM 1301 O4' C A 60 47.866 11.432 37.307 1.00 0.00 O
ATOM 1302 C3' C A 60 48.104 12.215 39.532 1.00 0.00 C
ATOM 1303 O3' C A 60 48.826 11.211 40.267 1.00 0.00 O
ATOM 1304 C2' C A 60 49.067 12.912 38.572 1.00 0.00 C
ATOM 1305 O2' C A 60 50.367 13.088 39.112 1.00 0.00 O
ATOM 1306 C1' C A 60 49.194 11.869 37.504 1.00 0.00 C
ATOM 1307 N1 C A 60 49.667 12.546 36.319 1.00 0.00 N
ATOM 1308 C2 C A 60 50.660 12.040 35.620 1.00 0.00 C
ATOM 1309 O2 C A 60 51.247 11.051 36.068 1.00 0.00 O
ATOM 1310 N3 C A 60 51.127 12.678 34.530 1.00 0.00 N
ATOM 1311 C4 C A 60 50.575 13.835 34.121 1.00 0.00 C
ATOM 1312 N4 C A 60 51.260 14.663 33.341 1.00 0.00 N
ATOM 1313 C5 C A 60 49.496 14.338 34.811 1.00 0.00 C
ATOM 1314 C6 C A 60 49.052 13.651 35.922 1.00 0.00 C
ATOM 1315 P C A 61 48.323 10.608 41.680 1.00 0.00 P
ATOM 1316 OP1 C A 61 49.269 9.580 42.074 1.00 0.00 O
ATOM 1317 OP2 C A 61 46.876 10.309 41.607 1.00 0.00 O
ATOM 1318 O5' C A 61 48.487 11.843 42.713 1.00 0.00 O
ATOM 1319 C5' C A 61 49.723 12.064 43.402 1.00 0.00 C
ATOM 1320 C4' C A 61 49.659 13.381 44.198 1.00 0.00 C
ATOM 1321 O4' C A 61 49.911 14.515 43.377 1.00 0.00 O
ATOM 1322 C3' C A 61 48.303 13.615 44.854 1.00 0.00 C
ATOM 1323 O3' C A 61 48.286 12.943 46.100 1.00 0.00 O
ATOM 1324 C2' C A 61 48.384 15.115 45.083 1.00 0.00 C
ATOM 1325 O2' C A 61 49.101 15.407 46.242 1.00 0.00 O
ATOM 1326 C1' C A 61 49.151 15.625 43.871 1.00 0.00 C
ATOM 1327 N1 C A 61 48.157 15.944 42.835 1.00 0.00 N
ATOM 1328 C2 C A 61 47.433 17.045 42.945 1.00 0.00 C
ATOM 1329 O2 C A 61 47.820 17.922 43.721 1.00 0.00 O
ATOM 1330 N3 C A 61 46.540 17.367 42.013 1.00 0.00 N
ATOM 1331 C4 C A 61 46.344 16.603 40.935 1.00 0.00 C
ATOM 1332 N4 C A 61 45.585 17.040 39.934 1.00 0.00 N
ATOM 1333 C5 C A 61 47.085 15.450 40.785 1.00 0.00 C
ATOM 1334 C6 C A 61 48.015 15.140 41.772 1.00 0.00 C
ATOM 1335 P A A 62 46.937 12.287 46.658 1.00 0.00 P
ATOM 1336 OP1 A A 62 47.341 11.345 47.733 1.00 0.00 O
ATOM 1337 OP2 A A 62 46.122 11.799 45.546 1.00 0.00 O
ATOM 1338 O5' A A 62 46.206 13.557 47.257 1.00 0.00 O
ATOM 1339 C5' A A 62 46.735 14.221 48.400 1.00 0.00 C
ATOM 1340 C4' A A 62 45.927 15.507 48.615 1.00 0.00 C
ATOM 1341 O4' A A 62 46.101 16.361 47.497 1.00 0.00 O
ATOM 1342 C3' A A 62 44.440 15.222 48.658 1.00 0.00 C
ATOM 1343 O3' A A 62 44.076 14.829 49.970 1.00 0.00 O
ATOM 1344 C2' A A 62 43.905 16.599 48.354 1.00 0.00 C
ATOM 1345 O2' A A 62 43.902 17.379 49.528 1.00 0.00 O
ATOM 1346 C1' A A 62 44.929 17.151 47.362 1.00 0.00 C
ATOM 1347 N9 A A 62 44.437 16.899 46.010 1.00 0.00 N
ATOM 1348 C8 A A 62 44.864 15.916 45.178 1.00 0.00 C
ATOM 1349 N7 A A 62 44.138 15.969 44.018 1.00 0.00 N
ATOM 1350 C5 A A 62 43.245 17.023 44.165 1.00 0.00 C
ATOM 1351 C6 A A 62 42.248 17.542 43.333 1.00 0.00 C
ATOM 1352 N6 A A 62 42.176 17.168 42.050 1.00 0.00 N
ATOM 1353 N1 A A 62 41.500 18.563 43.774 1.00 0.00 N
ATOM 1354 C2 A A 62 41.698 19.123 44.984 1.00 0.00 C
ATOM 1355 N3 A A 62 42.657 18.686 45.796 1.00 0.00 N
ATOM 1356 C4 A A 62 43.445 17.615 45.391 1.00 0.00 C
ATOM 1357 P C A 63 42.865 13.828 50.218 1.00 0.00 P
ATOM 1358 OP1 C A 63 43.031 13.445 51.617 1.00 0.00 O
ATOM 1359 OP2 C A 63 42.813 12.750 49.159 1.00 0.00 O
ATOM 1360 O5' C A 63 41.567 14.753 50.067 1.00 0.00 O
ATOM 1361 C5' C A 63 41.294 15.691 51.085 1.00 0.00 C
ATOM 1362 C4' C A 63 40.245 16.666 50.566 1.00 0.00 C
ATOM 1363 O4' C A 63 40.704 17.201 49.342 1.00 0.00 O
ATOM 1364 C3' C A 63 38.939 15.978 50.203 1.00 0.00 C
ATOM 1365 O3' C A 63 38.121 15.785 51.343 1.00 0.00 O
ATOM 1366 C2' C A 63 38.345 17.063 49.339 1.00 0.00 C
ATOM 1367 O2' C A 63 37.813 18.091 50.149 1.00 0.00 O
ATOM 1368 C1' C A 63 39.565 17.601 48.590 1.00 0.00 C
ATOM 1369 N1 C A 63 39.630 16.963 47.264 1.00 0.00 N
ATOM 1370 C2 C A 63 38.845 17.419 46.280 1.00 0.00 C
ATOM 1371 O2 C A 63 38.036 18.333 46.518 1.00 0.00 O
ATOM 1372 N3 C A 63 38.856 16.849 45.074 1.00 0.00 N
ATOM 1373 C4 C A 63 39.656 15.808 44.820 1.00 0.00 C
ATOM 1374 N4 C A 63 39.752 15.309 43.577 1.00 0.00 N
ATOM 1375 C5 C A 63 40.474 15.325 45.815 1.00 0.00 C
ATOM 1376 C6 C A 63 40.434 15.934 47.060 1.00 0.00 C
ATOM 1377 P A A 64 37.121 14.548 51.290 1.00 0.00 P
ATOM 1378 OP1 A A 64 36.531 14.280 52.624 1.00 0.00 O
ATOM 1379 OP2 A A 64 37.868 13.439 50.647 1.00 0.00 O
ATOM 1380 O5' A A 64 35.972 15.076 50.303 1.00 0.00 O
ATOM 1381 C5' A A 64 35.091 16.076 50.776 1.00 0.00 C
ATOM 1382 C4' A A 64 34.131 16.466 49.654 1.00 0.00 C
ATOM 1383 O4' A A 64 34.777 17.142 48.573 1.00 0.00 O
ATOM 1384 C3' A A 64 33.413 15.262 49.079 1.00 0.00 C
ATOM 1385 O3' A A 64 32.270 14.986 49.883 1.00 0.00 O
ATOM 1386 C2' A A 64 32.961 15.920 47.773 1.00 0.00 C
ATOM 1387 O2' A A 64 31.937 16.861 48.054 1.00 0.00 O
ATOM 1388 C1' A A 64 34.190 16.704 47.347 1.00 0.00 C
ATOM 1389 N9 A A 64 35.111 15.792 46.623 1.00 0.00 N
ATOM 1390 C8 A A 64 36.188 15.136 47.142 1.00 0.00 C
ATOM 1391 N7 A A 64 36.797 14.425 46.129 1.00 0.00 N
ATOM 1392 C5 A A 64 36.078 14.688 44.963 1.00 0.00 C
ATOM 1393 C6 A A 64 36.348 14.461 43.602 1.00 0.00 C
ATOM 1394 N6 A A 64 37.295 13.600 43.227 1.00 0.00 N
ATOM 1395 N1 A A 64 35.484 14.874 42.700 1.00 0.00 N
ATOM 1396 C2 A A 64 34.390 15.556 43.046 1.00 0.00 C
ATOM 1397 N3 A A 64 34.139 15.877 44.304 1.00 0.00 N
ATOM 1398 C4 A A 64 35.008 15.478 45.292 1.00 0.00 C
ATOM 1399 P G A 65 31.450 13.612 49.661 1.00 0.00 P
ATOM 1400 OP1 G A 65 30.260 13.622 50.558 1.00 0.00 O
ATOM 1401 OP2 G A 65 32.415 12.506 49.727 1.00 0.00 O
ATOM 1402 O5' G A 65 30.958 13.669 48.152 1.00 0.00 O
ATOM 1403 C5' G A 65 29.830 14.442 47.794 1.00 0.00 C
ATOM 1404 C4' G A 65 29.616 14.270 46.287 1.00 0.00 C
ATOM 1405 O4' G A 65 30.765 14.713 45.579 1.00 0.00 O
ATOM 1406 C3' G A 65 29.470 12.813 45.874 1.00 0.00 C
ATOM 1407 O3' G A 65 28.150 12.344 46.086 1.00 0.00 O
ATOM 1408 C2' G A 65 29.671 12.995 44.396 1.00 0.00 C
ATOM 1409 O2' G A 65 28.488 13.499 43.838 1.00 0.00 O
ATOM 1410 C1' G A 65 30.763 14.045 44.324 1.00 0.00 C
ATOM 1411 N9 G A 65 31.992 13.261 44.213 1.00 0.00 N
ATOM 1412 C8 G A 65 32.814 12.888 45.231 1.00 0.00 C
ATOM 1413 N7 G A 65 33.826 12.126 44.702 1.00 0.00 N
ATOM 1414 C5 G A 65 33.574 12.014 43.338 1.00 0.00 C
ATOM 1415 C6 G A 65 34.275 11.409 42.292 1.00 0.00 C
ATOM 1416 O6 G A 65 35.297 10.754 42.539 1.00 0.00 O
ATOM 1417 N1 G A 65 33.775 11.458 41.041 1.00 0.00 N
ATOM 1418 C2 G A 65 32.615 12.107 40.784 1.00 0.00 C
ATOM 1419 N2 G A 65 32.224 12.288 39.530 1.00 0.00 N
ATOM 1420 N3 G A 65 31.942 12.717 41.757 1.00 0.00 N
ATOM 1421 C4 G A 65 32.429 12.695 43.048 1.00 0.00 C
ATOM 1422 P A A 66 27.820 10.788 45.920 1.00 0.00 P
ATOM 1423 OP1 A A 66 26.447 10.564 46.430 1.00 0.00 O
ATOM 1424 OP2 A A 66 28.950 9.981 46.463 1.00 0.00 O
ATOM 1425 O5' A A 66 27.770 10.561 44.338 1.00 0.00 O
ATOM 1426 C5' A A 66 26.561 10.663 43.612 1.00 0.00 C
ATOM 1427 C4' A A 66 26.989 10.472 42.174 1.00 0.00 C
ATOM 1428 O4' A A 66 28.307 10.986 42.051 1.00 0.00 O
ATOM 1429 C3' A A 66 27.189 9.025 41.880 1.00 0.00 C
ATOM 1430 O3' A A 66 25.919 8.448 41.652 1.00 0.00 O
ATOM 1431 C2' A A 66 28.050 9.130 40.621 1.00 0.00 C
ATOM 1432 O2' A A 66 27.267 9.503 39.508 1.00 0.00 O
ATOM 1433 C1' A A 66 28.962 10.301 40.982 1.00 0.00 C
ATOM 1434 N9 A A 66 30.182 9.786 41.577 1.00 0.00 N
ATOM 1435 C8 A A 66 30.489 9.857 42.881 1.00 0.00 C
ATOM 1436 N7 A A 66 31.676 9.235 43.083 1.00 0.00 N
ATOM 1437 C5 A A 66 32.090 8.751 41.850 1.00 0.00 C
ATOM 1438 C6 A A 66 33.257 8.111 41.436 1.00 0.00 C
ATOM 1439 N6 A A 66 34.214 7.832 42.324 1.00 0.00 N
ATOM 1440 N1 A A 66 33.396 7.759 40.154 1.00 0.00 N
ATOM 1441 C2 A A 66 32.437 8.022 39.253 1.00 0.00 C
ATOM 1442 N3 A A 66 31.329 8.672 39.592 1.00 0.00 N
ATOM 1443 C4 A A 66 31.153 9.071 40.911 1.00 0.00 C
ATOM 1444 P A A 67 25.780 6.899 42.000 1.00 0.00 P
ATOM 1445 OP1 A A 67 24.355 6.518 41.920 1.00 0.00 O
ATOM 1446 OP2 A A 67 26.570 6.529 43.204 1.00 0.00 O
ATOM 1447 O5' A A 67 26.480 6.271 40.744 1.00 0.00 O
ATOM 1448 C5' A A 67 25.796 6.283 39.503 1.00 0.00 C
ATOM 1449 C4' A A 67 26.762 5.597 38.556 1.00 0.00 C
ATOM 1450 O4' A A 67 28.022 6.236 38.741 1.00 0.00 O
ATOM 1451 C3' A A 67 26.971 4.171 39.028 1.00 0.00 C
ATOM 1452 O3' A A 67 25.983 3.274 38.507 1.00 0.00 O
ATOM 1453 C2' A A 67 28.334 3.926 38.411 1.00 0.00 C
ATOM 1454 O2' A A 67 28.164 3.777 37.017 1.00 0.00 O
ATOM 1455 C1' A A 67 29.044 5.256 38.666 1.00 0.00 C
ATOM 1456 N9 A A 67 29.832 5.239 39.937 1.00 0.00 N
ATOM 1457 C8 A A 67 29.533 5.866 41.083 1.00 0.00 C
ATOM 1458 N7 A A 67 30.574 5.672 41.981 1.00 0.00 N
ATOM 1459 C5 A A 67 31.545 4.937 41.320 1.00 0.00 C
ATOM 1460 C6 A A 67 32.853 4.544 41.653 1.00 0.00 C
ATOM 1461 N6 A A 67 33.269 4.555 42.921 1.00 0.00 N
ATOM 1462 N1 A A 67 33.565 3.865 40.765 1.00 0.00 N
ATOM 1463 C2 A A 67 33.087 3.580 39.552 1.00 0.00 C
ATOM 1464 N3 A A 67 31.880 3.961 39.184 1.00 0.00 N
ATOM 1465 C4 A A 67 31.073 4.657 40.071 1.00 0.00 C
ATOM 1466 P U A 68 25.802 1.843 39.236 1.00 0.00 P
ATOM 1467 OP1 U A 68 24.612 1.146 38.716 1.00 0.00 O
ATOM 1468 OP2 U A 68 25.963 2.046 40.685 1.00 0.00 O
ATOM 1469 O5' U A 68 27.051 0.993 38.818 1.00 0.00 O
ATOM 1470 C5' U A 68 27.095 0.337 37.581 1.00 0.00 C
ATOM 1471 C4' U A 68 28.484 -0.269 37.566 1.00 0.00 C
ATOM 1472 O4' U A 68 29.421 0.715 38.000 1.00 0.00 O
ATOM 1473 C3' U A 68 28.614 -1.360 38.614 1.00 0.00 C
ATOM 1474 O3' U A 68 28.025 -2.554 38.112 1.00 0.00 O
ATOM 1475 C2' U A 68 30.133 -1.460 38.572 1.00 0.00 C
ATOM 1476 O2' U A 68 30.493 -2.064 37.338 1.00 0.00 O
ATOM 1477 C1' U A 68 30.560 0.009 38.486 1.00 0.00 C
ATOM 1478 N1 U A 68 30.839 0.540 39.820 1.00 0.00 N
ATOM 1479 C2 U A 68 32.053 0.363 40.365 1.00 0.00 C
ATOM 1480 O2 U A 68 32.801 -0.513 39.904 1.00 0.00 O
ATOM 1481 N3 U A 68 32.330 0.847 41.568 1.00 0.00 N
ATOM 1482 C4 U A 68 31.416 1.481 42.272 1.00 0.00 C
ATOM 1483 O4 U A 68 31.741 2.042 43.329 1.00 0.00 O
ATOM 1484 C5 U A 68 30.134 1.655 41.752 1.00 0.00 C
ATOM 1485 C6 U A 68 29.880 1.166 40.479 1.00 0.00 C
ATOM 1486 P U A 69 27.633 -3.737 39.128 1.00 0.00 P
ATOM 1487 OP1 U A 69 27.064 -4.859 38.344 1.00 0.00 O
ATOM 1488 OP2 U A 69 26.907 -3.193 40.279 1.00 0.00 O
ATOM 1489 O5' U A 69 29.063 -4.175 39.672 1.00 0.00 O
ATOM 1490 C5' U A 69 29.862 -5.049 38.890 1.00 0.00 C
ATOM 1491 C4' U A 69 31.119 -5.299 39.704 1.00 0.00 C
ATOM 1492 O4' U A 69 31.630 -4.030 40.099 1.00 0.00 O
ATOM 1493 C3' U A 69 30.760 -5.974 41.023 1.00 0.00 C
ATOM 1494 O3' U A 69 30.601 -7.387 40.860 1.00 0.00 O
ATOM 1495 C2' U A 69 31.997 -5.586 41.846 1.00 0.00 C
ATOM 1496 O2' U A 69 33.127 -6.344 41.429 1.00 0.00 O
ATOM 1497 C1' U A 69 32.261 -4.156 41.371 1.00 0.00 C
ATOM 1498 N1 U A 69 31.662 -3.155 42.258 1.00 0.00 N
ATOM 1499 C2 U A 69 32.332 -2.730 43.337 1.00 0.00 C
ATOM 1500 O2 U A 69 33.477 -3.145 43.554 1.00 0.00 O
ATOM 1501 N3 U A 69 31.815 -1.810 44.147 1.00 0.00 N
ATOM 1502 C4 U A 69 30.636 -1.274 43.904 1.00 0.00 C
ATOM 1503 O4 U A 69 30.243 -0.320 44.585 1.00 0.00 O
ATOM 1504 C5 U A 69 29.931 -1.665 42.786 1.00 0.00 C
ATOM 1505 C6 U A 69 30.491 -2.625 41.954 1.00 0.00 C
ATOM 1506 P C A 70 29.732 -8.195 41.958 1.00 0.00 P
ATOM 1507 OP1 C A 70 29.406 -9.571 41.467 1.00 0.00 O
ATOM 1508 OP2 C A 70 28.618 -7.293 42.327 1.00 0.00 O
ATOM 1509 O5' C A 70 30.704 -8.299 43.224 1.00 0.00 O
ATOM 1510 C5' C A 70 31.833 -9.161 43.208 1.00 0.00 C
ATOM 1511 C4' C A 70 32.758 -8.842 44.405 1.00 0.00 C
ATOM 1512 O4' C A 70 33.207 -7.488 44.392 1.00 0.00 O
ATOM 1513 C3' C A 70 32.108 -9.034 45.774 1.00 0.00 C
ATOM 1514 O3' C A 70 32.088 -10.414 46.118 1.00 0.00 O
ATOM 1515 C2' C A 70 33.171 -8.317 46.596 1.00 0.00 C
ATOM 1516 O2' C A 70 34.336 -9.119 46.660 1.00 0.00 O
ATOM 1517 C1' C A 70 33.498 -7.101 45.740 1.00 0.00 C
ATOM 1518 N1 C A 70 32.621 -5.974 46.158 1.00 0.00 N
ATOM 1519 C2 C A 70 32.981 -5.216 47.207 1.00 0.00 C
ATOM 1520 O2 C A 70 34.113 -5.344 47.678 1.00 0.00 O
ATOM 1521 N3 C A 70 32.229 -4.184 47.608 1.00 0.00 N
ATOM 1522 C4 C A 70 31.102 -3.867 46.973 1.00 0.00 C
ATOM 1523 N4 C A 70 30.378 -2.818 47.371 1.00 0.00 N
ATOM 1524 C5 C A 70 30.706 -4.623 45.871 1.00 0.00 C
ATOM 1525 C6 C A 70 31.510 -5.688 45.475 1.00 0.00 C
ATOM 1526 P G A 71 31.226 -10.948 47.370 1.00 0.00 P
ATOM 1527 OP1 G A 71 31.537 -12.391 47.508 1.00 0.00 O
ATOM 1528 OP2 G A 71 29.821 -10.501 47.254 1.00 0.00 O
ATOM 1529 O5' G A 71 31.851 -10.222 48.650 1.00 0.00 O
ATOM 1530 C5' G A 71 32.755 -11.009 49.418 1.00 0.00 C
ATOM 1531 C4' G A 71 33.302 -10.171 50.560 1.00 0.00 C
ATOM 1532 O4' G A 71 33.485 -8.869 50.038 1.00 0.00 O
ATOM 1533 C3' G A 71 32.293 -9.967 51.686 1.00 0.00 C
ATOM 1534 O3' G A 71 32.270 -11.042 52.628 1.00 0.00 O
ATOM 1535 C2' G A 71 32.856 -8.700 52.328 1.00 0.00 C
ATOM 1536 O2' G A 71 33.846 -8.934 53.339 1.00 0.00 O
ATOM 1537 C1' G A 71 33.462 -7.964 51.136 1.00 0.00 C
ATOM 1538 N9 G A 71 32.509 -6.906 50.816 1.00 0.00 N
ATOM 1539 C8 G A 71 31.621 -6.879 49.783 1.00 0.00 C
ATOM 1540 N7 G A 71 30.905 -5.719 49.879 1.00 0.00 N
ATOM 1541 C5 G A 71 31.344 -5.077 51.031 1.00 0.00 C
ATOM 1542 C6 G A 71 30.957 -3.906 51.671 1.00 0.00 C
ATOM 1543 O6 G A 71 30.058 -3.201 51.191 1.00 0.00 O
ATOM 1544 N1 G A 71 31.555 -3.550 52.818 1.00 0.00 N
ATOM 1545 C2 G A 71 32.519 -4.304 53.384 1.00 0.00 C
ATOM 1546 N2 G A 71 33.311 -3.761 54.317 1.00 0.00 N
ATOM 1547 N3 G A 71 32.898 -5.432 52.804 1.00 0.00 N
ATOM 1548 C4 G A 71 32.310 -5.825 51.615 1.00 0.00 C
ATOM 1549 P C A 72 30.858 -11.284 53.336 1.00 0.00 P
ATOM 1550 OP1 C A 72 30.874 -12.510 54.144 1.00 0.00 O
ATOM 1551 OP2 C A 72 29.834 -11.140 52.289 1.00 0.00 O
ATOM 1552 O5' C A 72 30.739 -10.036 54.296 1.00 0.00 O
ATOM 1553 C5' C A 72 31.447 -9.996 55.526 1.00 0.00 C
ATOM 1554 C4' C A 72 31.078 -8.645 56.121 1.00 0.00 C
ATOM 1555 O4' C A 72 31.072 -7.733 55.032 1.00 0.00 O
ATOM 1556 C3' C A 72 29.610 -8.609 56.531 1.00 0.00 C
ATOM 1557 O3' C A 72 29.360 -9.194 57.805 1.00 0.00 O
ATOM 1558 C2' C A 72 29.407 -7.109 56.590 1.00 0.00 C
ATOM 1559 O2' C A 72 30.021 -6.553 57.749 1.00 0.00 O
ATOM 1560 C1' C A 72 30.212 -6.659 55.394 1.00 0.00 C
ATOM 1561 N1 C A 72 29.306 -6.309 54.298 1.00 0.00 N
ATOM 1562 C2 C A 72 28.696 -5.141 54.356 1.00 0.00 C
ATOM 1563 O2 C A 72 29.038 -4.348 55.240 1.00 0.00 O
ATOM 1564 N3 C A 72 27.886 -4.720 53.391 1.00 0.00 N
ATOM 1565 C4 C A 72 27.662 -5.450 52.327 1.00 0.00 C
ATOM 1566 N4 C A 72 27.356 -4.807 51.209 1.00 0.00 N
ATOM 1567 C5 C A 72 28.288 -6.700 52.236 1.00 0.00 C
ATOM 1568 C6 C A 72 29.141 -7.108 53.263 1.00 0.00 C
ATOM 1569 P A A 73 27.846 -9.558 58.168 1.00 0.00 P
ATOM 1570 OP1 A A 73 27.884 -10.226 59.479 1.00 0.00 O
ATOM 1571 OP2 A A 73 27.214 -10.253 57.023 1.00 0.00 O
ATOM 1572 O5' A A 73 27.114 -8.144 58.331 1.00 0.00 O
ATOM 1573 C5' A A 73 27.403 -7.310 59.456 1.00 0.00 C
ATOM 1574 C4' A A 73 26.663 -5.966 59.336 1.00 0.00 C
ATOM 1575 O4' A A 73 27.043 -5.302 58.141 1.00 0.00 O
ATOM 1576 C3' A A 73 25.157 -6.131 59.204 1.00 0.00 C
ATOM 1577 O3' A A 73 24.534 -6.262 60.469 1.00 0.00 O
ATOM 1578 C2' A A 73 24.810 -4.761 58.658 1.00 0.00 C
ATOM 1579 O2' A A 73 24.920 -3.805 59.690 1.00 0.00 O
ATOM 1580 C1' A A 73 25.933 -4.535 57.671 1.00 0.00 C
ATOM 1581 N9 A A 73 25.497 -5.077 56.371 1.00 0.00 N
ATOM 1582 C8 A A 73 25.805 -6.306 55.870 1.00 0.00 C
ATOM 1583 N7 A A 73 25.276 -6.407 54.608 1.00 0.00 N
ATOM 1584 C5 A A 73 24.599 -5.215 54.355 1.00 0.00 C
ATOM 1585 C6 A A 73 24.019 -4.680 53.200 1.00 0.00 C
ATOM 1586 N6 A A 73 23.817 -5.455 52.138 1.00 0.00 N
ATOM 1587 N1 A A 73 23.446 -3.480 53.253 1.00 0.00 N
ATOM 1588 C2 A A 73 23.438 -2.752 54.383 1.00 0.00 C
ATOM 1589 N3 A A 73 24.045 -3.187 55.482 1.00 0.00 N
ATOM 1590 C4 A A 73 24.667 -4.428 55.477 1.00 0.00 C
ATOM 1591 P C A 74 23.083 -6.943 60.527 1.00 0.00 P
ATOM 1592 OP1 C A 74 22.567 -6.766 61.910 1.00 0.00 O
ATOM 1593 OP2 C A 74 23.174 -8.315 59.982 1.00 0.00 O
ATOM 1594 O5' C A 74 22.193 -6.047 59.557 1.00 0.00 O
ATOM 1595 C5' C A 74 21.661 -4.861 60.114 1.00 0.00 C
ATOM 1596 C4' C A 74 20.580 -4.418 59.156 1.00 0.00 C
ATOM 1597 O4' C A 74 21.142 -4.300 57.857 1.00 0.00 O
ATOM 1598 C3' C A 74 19.560 -5.541 59.003 1.00 0.00 C
ATOM 1599 O3' C A 74 18.692 -5.581 60.139 1.00 0.00 O
ATOM 1600 C2' C A 74 18.874 -5.002 57.757 1.00 0.00 C
ATOM 1601 O2' C A 74 18.083 -3.909 58.157 1.00 0.00 O
ATOM 1602 C1' C A 74 20.068 -4.463 56.932 1.00 0.00 C
ATOM 1603 N1 C A 74 20.534 -5.449 55.936 1.00 0.00 N
ATOM 1604 C2 C A 74 19.964 -5.491 54.718 1.00 0.00 C
ATOM 1605 O2 C A 74 19.242 -4.543 54.357 1.00 0.00 O
ATOM 1606 N3 C A 74 20.374 -6.383 53.800 1.00 0.00 N
ATOM 1607 C4 C A 74 21.361 -7.228 54.060 1.00 0.00 C
ATOM 1608 N4 C A 74 21.939 -7.882 53.058 1.00 0.00 N
ATOM 1609 C5 C A 74 21.981 -7.192 55.308 1.00 0.00 C
ATOM 1610 C6 C A 74 21.544 -6.262 56.243 1.00 0.00 C
ATOM 1611 P C A 75 18.015 -6.964 60.608 1.00 0.00 P
ATOM 1612 OP1 C A 75 17.546 -6.778 61.990 1.00 0.00 O
ATOM 1613 OP2 C A 75 18.940 -8.079 60.315 1.00 0.00 O
ATOM 1614 O5' C A 75 16.716 -7.130 59.707 1.00 0.00 O
ATOM 1615 C5' C A 75 15.640 -6.214 59.821 1.00 0.00 C
ATOM 1616 C4' C A 75 14.855 -6.313 58.510 1.00 0.00 C
ATOM 1617 O4' C A 75 15.797 -6.156 57.438 1.00 0.00 O
ATOM 1618 C3' C A 75 14.211 -7.700 58.319 1.00 0.00 C
ATOM 1619 O3' C A 75 12.855 -7.781 58.767 1.00 0.00 O
ATOM 1620 C2' C A 75 14.147 -7.709 56.805 1.00 0.00 C
ATOM 1621 O2' C A 75 13.111 -6.822 56.381 1.00 0.00 O
ATOM 1622 C1' C A 75 15.473 -7.084 56.392 1.00 0.00 C
ATOM 1623 N1 C A 75 16.612 -8.039 56.213 1.00 0.00 N
ATOM 1624 C2 C A 75 16.561 -9.067 55.322 1.00 0.00 C
ATOM 1625 O2 C A 75 15.454 -9.511 54.967 1.00 0.00 O
ATOM 1626 N3 C A 75 17.668 -9.832 55.092 1.00 0.00 N
ATOM 1627 C4 C A 75 18.822 -9.594 55.738 1.00 0.00 C
ATOM 1628 N4 C A 75 19.874 -10.403 55.608 1.00 0.00 N
ATOM 1629 C5 C A 75 18.865 -8.570 56.662 1.00 0.00 C
ATOM 1630 C6 C A 75 17.728 -7.797 56.867 1.00 0.00 C
ATOM 1631 P A A 76 12.264 -9.231 58.970 1.00 0.00 P
ATOM 1632 OP1 A A 76 12.790 -9.675 60.257 1.00 0.00 O
ATOM 1633 OP2 A A 76 12.602 -10.105 57.867 1.00 0.00 O
ATOM 1634 O5' A A 76 10.679 -9.104 59.055 1.00 0.00 O
ATOM 1635 C5' A A 76 9.825 -9.098 57.929 1.00 0.00 C
ATOM 1636 C4' A A 76 8.364 -9.348 58.370 1.00 0.00 C
ATOM 1637 O4' A A 76 8.367 -9.987 59.649 1.00 0.00 O
ATOM 1638 C3' A A 76 7.584 -8.037 58.555 1.00 0.00 C
ATOM 1639 O3' A A 76 6.222 -8.269 58.232 1.00 0.00 O
ATOM 1640 C2' A A 76 7.687 -7.749 60.045 1.00 0.00 C
ATOM 1641 O2' A A 76 6.523 -7.042 60.481 1.00 0.00 O
ATOM 1642 C1' A A 76 7.696 -9.164 60.618 1.00 0.00 C
ATOM 1643 N9 A A 76 8.430 -9.185 61.902 1.00 0.00 N
ATOM 1644 C8 A A 76 9.781 -9.097 62.038 1.00 0.00 C
ATOM 1645 N7 A A 76 10.101 -9.181 63.361 1.00 0.00 N
ATOM 1646 C5 A A 76 8.905 -9.328 64.047 1.00 0.00 C
ATOM 1647 C6 A A 76 8.626 -9.568 65.392 1.00 0.00 C
ATOM 1648 N6 A A 76 9.540 -9.257 66.289 1.00 0.00 N
ATOM 1649 N1 A A 76 7.358 -9.696 65.778 1.00 0.00 N
ATOM 1650 C2 A A 76 6.345 -9.605 64.898 1.00 0.00 C
ATOM 1651 N3 A A 76 6.568 -9.405 63.599 1.00 0.00 N
ATOM 1652 C4 A A 76 7.870 -9.283 63.150 1.00 0.00 C
TER 1653 A A 76
HETATM 1654 MG MG A 77 36.200 1.700 27.800 1.00 0.00 MG
HETATM 1655 MG MG A 78 50.300 18.900 25.500 1.00 0.00 MG
HETATM 1656 MG MG A 79 54.500 11.900 31.300 1.00 0.00 MG
HETATM 1657 MG MG A 80 9.200 11.800 27.500 1.00 0.00 MG
CONECT 181 195
CONECT 195 181 196 197 198
CONECT 196 195
CONECT 197 195
CONECT 198 195 199
CONECT 199 198 200
CONECT 200 199 201 202
CONECT 201 200 206
CONECT 202 200 203 204
CONECT 203 202 219
CONECT 204 202 205 206
CONECT 205 204
CONECT 206 201 204 207
CONECT 207 206 208 218
CONECT 208 207 209
CONECT 209 208 210
CONECT 210 209 211 218
CONECT 211 210 212 213
CONECT 212 211
CONECT 213 211 214
CONECT 214 213 215 217
CONECT 215 214 216
CONECT 216 215
CONECT 217 214 218
CONECT 218 207 210 217
CONECT 219 203
CONECT 309 324
CONECT 324 309 325 326 327
CONECT 325 324
CONECT 326 324
CONECT 327 324 328
CONECT 328 327 329
CONECT 329 328 330 331
CONECT 330 329 333
CONECT 331 329 332 334
CONECT 332 331 344
CONECT 333 330 334 336
CONECT 334 331 333 335
CONECT 335 334
CONECT 336 333 337 343
CONECT 337 336 338 339
CONECT 338 337
CONECT 339 337 340
CONECT 340 339 341 342
CONECT 341 340
CONECT 342 340 343
CONECT 343 336 342
CONECT 344 332 345 346 347
CONECT 345 344
CONECT 346 344
CONECT 347 344 348
CONECT 348 347 349
CONECT 349 348 350 351
CONECT 350 349 353
CONECT 351 349 352 354
CONECT 352 351 364
CONECT 353 350 354 356
CONECT 354 351 353 355
CONECT 355 354
CONECT 356 353 357 363
CONECT 357 356 358 359
CONECT 358 357
CONECT 359 357 360
CONECT 360 359 361 362
CONECT 361 360
CONECT 362 360 363
CONECT 363 356 362
CONECT 364 352
CONECT 388 1656
CONECT 435 1655
CONECT 531 543
CONECT 543 531 544 545 546
CONECT 544 543
CONECT 545 543
CONECT 546 543 547
CONECT 547 546 548
CONECT 548 547 549 550
CONECT 549 548 554
CONECT 550 548 551 552
CONECT 551 550 568
CONECT 552 550 553 554
CONECT 553 552
CONECT 554 549 552 555
CONECT 555 554 556 565
CONECT 556 555 557
CONECT 557 556 558
CONECT 558 557 559 565
CONECT 559 558 560 561
CONECT 560 559
CONECT 561 559 562
CONECT 562 561 563 564
CONECT 563 562 566 567
CONECT 564 562 565
CONECT 565 555 558 564
CONECT 566 563
CONECT 567 563
CONECT 568 551
CONECT 661 693
CONECT 675 676 680 683
CONECT 676 675 677 681
CONECT 677 676 678
CONECT 678 677 679 682
CONECT 679 678 680
CONECT 680 675 679
CONECT 681 676
CONECT 682 678
CONECT 683 675 684 689
CONECT 684 683 685 687
CONECT 685 684 686
CONECT 686 685
CONECT 687 684 688 690
CONECT 688 687 689 691
CONECT 689 683 688
CONECT 690 687 696
CONECT 691 688 692
CONECT 692 691 693
CONECT 693 661 692 694 695
CONECT 694 693
CONECT 695 693
CONECT 696 690
CONECT 704 716
CONECT 716 704 717 718 719
CONECT 717 716
CONECT 718 716
CONECT 719 716 720
CONECT 720 719 721
CONECT 721 720 722 723
CONECT 722 721 728
CONECT 723 721 724 725
CONECT 724 723 740
CONECT 725 723 726 728
CONECT 726 725 727
CONECT 727 726
CONECT 728 722 725 729
CONECT 729 728 730 739
CONECT 730 729 731
CONECT 731 730 732
CONECT 732 731 733 739
CONECT 733 732 734 735
CONECT 734 733
CONECT 735 733 736
CONECT 736 735 737 738
CONECT 737 736
CONECT 738 736 739
CONECT 739 729 732 738
CONECT 740 724
CONECT 770 820
CONECT 784 786 791 798
CONECT 785 786 797
CONECT 786 784 785 787
CONECT 787 786 788 789
CONECT 788 787
CONECT 789 787 790 795
CONECT 790 789 791 793
CONECT 791 784 790 792
CONECT 792 791
CONECT 793 790 794
CONECT 794 793 795
CONECT 795 789 794 811
CONECT 796 797
CONECT 797 785 796 798
CONECT 798 784 797 799
CONECT 799 798 800
CONECT 800 799 801
CONECT 801 800 802 806
CONECT 802 801 803 804
CONECT 803 802
CONECT 804 802 805
CONECT 805 804
CONECT 806 801 807
CONECT 807 806 808 809
CONECT 808 807
CONECT 809 807 810
CONECT 810 809
CONECT 811 795 812 817
CONECT 812 811 813 814
CONECT 813 812
CONECT 814 812 815 816
CONECT 815 814 823
CONECT 816 814 817 818
CONECT 817 811 816
CONECT 818 816 819
CONECT 819 818 820
CONECT 820 770 819 821 822
CONECT 821 820
CONECT 822 820
CONECT 823 815
CONECT 831 862
CONECT 845 846 850
CONECT 846 845 847 851
CONECT 847 846 848
CONECT 848 847 849 852
CONECT 849 848 850 853
CONECT 850 845 849
CONECT 851 846
CONECT 852 848
CONECT 853 849 854 859
CONECT 854 853 855 856
CONECT 855 854
CONECT 856 854 857 858
CONECT 857 856 859 860
CONECT 858 856 865
CONECT 859 853 857
CONECT 860 857 861
CONECT 861 860 862
CONECT 862 831 861 863 864
CONECT 863 862
CONECT 864 862
CONECT 865 858 866 867 868
CONECT 866 865
CONECT 867 865
CONECT 868 865 869
CONECT 869 868 870
CONECT 870 869 871 872
CONECT 871 870 876
CONECT 872 870 873 874
CONECT 873 872 886
CONECT 874 872 875 876
CONECT 875 874
CONECT 876 871 874 877
CONECT 877 876 878 884
CONECT 878 877 879 880
CONECT 879 878
CONECT 880 878 881
CONECT 881 880 882 883
CONECT 882 881
CONECT 883 881 884 885
CONECT 884 877 883
CONECT 885 883
CONECT 886 873
CONECT 982 997
CONECT 997 982 998 999 1000
CONECT 998 997
CONECT 999 997
CONECT 1000 997 1001
CONECT 1001 1000 1002
CONECT 1002 1001 1003 1004
CONECT 1003 1002 1008
CONECT 1004 1002 1005 1006
CONECT 1005 1004 1021
CONECT 1006 1004 1007 1008
CONECT 1007 1006
CONECT 1008 1003 1006 1009
CONECT 1009 1008 1010 1019
CONECT 1010 1009 1011
CONECT 1011 1010 1012 1020
CONECT 1012 1011 1013 1019
CONECT 1013 1012 1014 1015
CONECT 1014 1013
CONECT 1015 1013 1016
CONECT 1016 1015 1017 1018
CONECT 1017 1016
CONECT 1018 1016 1019
CONECT 1019 1009 1012 1018
CONECT 1020 1011
CONECT 1021 1005
CONECT 1049 1061
CONECT 1061 1049 1062 1063 1064
CONECT 1062 1061
CONECT 1063 1061
CONECT 1064 1061 1065
CONECT 1065 1064 1066
CONECT 1066 1065 1067 1068
CONECT 1067 1066 1072
CONECT 1068 1066 1069 1070
CONECT 1069 1068 1082
CONECT 1070 1068 1071 1072
CONECT 1071 1070
CONECT 1072 1067 1070 1073
CONECT 1073 1072 1074 1080
CONECT 1074 1073 1075 1076
CONECT 1075 1074
CONECT 1076 1074 1077
CONECT 1077 1076 1078 1079
CONECT 1078 1077
CONECT 1079 1077 1080 1081
CONECT 1080 1073 1079
CONECT 1081 1079
CONECT 1082 1069
CONECT 1153 1186
CONECT 1168 1169 1174 1177
CONECT 1169 1168 1170 1175
CONECT 1170 1169 1171
CONECT 1171 1170 1172 1176
CONECT 1172 1171 1173 1174
CONECT 1173 1172
CONECT 1174 1168 1172
CONECT 1175 1169
CONECT 1176 1171
CONECT 1177 1168 1178 1183
CONECT 1178 1177 1179 1180
CONECT 1179 1178
CONECT 1180 1178 1181 1182
CONECT 1181 1180 1183 1184
CONECT 1182 1180 1206
CONECT 1183 1177 1181
CONECT 1184 1181 1185
CONECT 1185 1184 1186
CONECT 1186 1153 1185 1187 1188
CONECT 1187 1186
CONECT 1188 1186
CONECT 1189 1190 1194
CONECT 1190 1189 1191 1195
CONECT 1191 1190 1192
CONECT 1192 1191 1193 1196
CONECT 1193 1192 1194 1197
CONECT 1194 1189 1193
CONECT 1195 1190
CONECT 1196 1192
CONECT 1197 1193 1198 1203
CONECT 1198 1197 1199 1200
CONECT 1199 1198
CONECT 1200 1198 1201 1202
CONECT 1201 1200 1203 1204
CONECT 1202 1200 1209
CONECT 1203 1197 1201
CONECT 1204 1201 1205
CONECT 1205 1204 1206
CONECT 1206 1182 1205 1207 1208
CONECT 1207 1206
CONECT 1208 1206
CONECT 1209 1202
CONECT 1237 1252
CONECT 1252 1237 1253 1254 1255
CONECT 1253 1252
CONECT 1254 1252
CONECT 1255 1252 1256
CONECT 1256 1255 1257
CONECT 1257 1256 1258 1259
CONECT 1258 1257 1263
CONECT 1259 1257 1260 1261
CONECT 1260 1259 1275
CONECT 1261 1259 1262 1263
CONECT 1262 1261
CONECT 1263 1258 1261 1264
CONECT 1264 1263 1265 1274
CONECT 1265 1264 1266
CONECT 1266 1265 1267
CONECT 1267 1266 1268 1274
CONECT 1268 1267 1269 1270
CONECT 1269 1268
CONECT 1270 1268 1271 1272
CONECT 1271 1270
CONECT 1272 1270 1273
CONECT 1273 1272 1274
CONECT 1274 1264 1267 1273
CONECT 1275 1260
CONECT 1655 435
CONECT 1656 388
MASTER 434 0 18 0 0 0 2 6 1656 1 349 6
END
Ribosomska rRNA je sastavni dio ribosoma, staničnih struktura na kojima se odvija biosinteza proteina. Ribosomi su građeni od 2 podjedinice - male i velike. Svaka je podjedinica građena od proteina i rRNA. Nakon transkripcije (prepisivanja) genetičke informacije u jezgri, u citoplazmi dolazi do translacije. Translacija ili prevođenje se zbiva na ribosomima gdje se genetička uputa na mRNA prevodi u redoslijed aminokiselina u proteinu.
Ribosomska rRNA je sastavni dio ribosoma.
Ribosomi su stanične strukture na kojima se odvija biosinteza proteina.
Ribosomi su građeni od 2 podjedinice - male i velike.
Svaka je podjedinica građena od proteina i rRNA.
Nakon transkripcije (prepisivanja) genetičke informacije u jezgri, u citoplazmi dolazi do translacije.
Translacija ili prevođenje se zbiva na ribosomima
gdje se genetička uputa na mRNA prevodi u redoslijed aminokiselina u proteinu.
Problemski zadatak
Na animaciji sinteze proteina uočite kako je prikazana trodimenzijska struktura ribosoma i gdje se na ribosomu smjesti molukula mRNA koja došla iz stanične jezgre, kroz pore na jezgrinoj membarani. Obrazložite zašto iz jezgre ne izlazi molekula DNA te zašto je molekula mRNA znatno manja od molekule DNA. Izračunajte brzinu kojom se vežu dvije aminokiseline, ako prikazani ribosom u jednoj minuti sintetizira polipeptid od 300 aminokiselina.
Na animaciji sinteze proteina uočite kako je prikazana trodimenzijska struktura ribosoma.
Gdje se na ribosomu smjesti molukula mRNA koja došla iz stanične jezgre, kroz pore na jezgrinoj membarani.
Obrazložite zašto iz jezgre ne izlazi molekula DNA.
Zašto je molekula mRNA znatno manja od molekule DNA.
Izračunajte brzinu kojom se vežu dvije aminokiseline,
ako prikazani ribosom u jednoj minuti sintetizira polipeptid od 300 aminokiselina.
Biosinteza proteina
Na jednom se ribosomu sintetizira polipeptid prosječne veličine (oko 400 aminokiselina) i to za manje od jedne minute. Međutim jedna mRNA služi za istovremenu sintezu mnogo kopija polipeptida, jer nekoliko ribosoma istovremeno "čitaju" i prevode poruku zapisanu u jednoj mRNA. Takve nakupine ribosoma zovemo poliribosomi i one se mogu vidjeti elektronskim mikroskopom.
Na jednom se ribosomu sintetizira polipeptid prosječne veličine (oko 400 aminokiselina) i to za manje od jedne minute.
Međutim, jedna mRNA služi za istovremenu sintezu mnogo kopija polipeptida.
To je zato jer nekoliko ribosoma istovremeno "čitaju" i prevode poruku zapisanu u jednoj mRNA.
Takve nakupine ribosoma zovemo poliribosomi.
Oni se mogu vidjeti elektronskim mikroskopom.